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dc.contributor.authorO`Connell, Kevinen_US
dc.contributor.authorShadrin, Alexey A.en_US
dc.contributor.authorBahrami, Shahramen_US
dc.contributor.authorSmeland, Olav Bjerkehagenen_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorFrei, Oleksandren_US
dc.contributor.authorKrull, Florianen_US
dc.contributor.authorAskeland, Ragna Buggeen_US
dc.contributor.authorWalters, Bragien_US
dc.contributor.authorDavíðsdóttir, Katrínen_US
dc.contributor.authorHaraldsdóttir, Gyðaen_US
dc.contributor.authorGuðmundsson, Ólafuren_US
dc.contributor.authorStefánsson, Hreinnen_US
dc.contributor.authorFan, Chun C.en_US
dc.contributor.authorSteen, Nils Eielen_US
dc.contributor.authorReichborn-Kjennerud, Teden_US
dc.contributor.authorDale, Andersen_US
dc.contributor.authorStefánsson, Kárien_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.date.accessioned2020-07-03T08:37:06Z
dc.date.available2020-07-03T08:37:06Z
dc.date.issued2019
dc.PublishedO`Connell K, Shadrin AA, Bahrami S, Smeland OB, Bettella F, Frei O, Krull F, Askeland RB, Walters B, Davíðsdóttir, Haraldsdóttir, Guðmundsson, Stefánsson H, Fan CC, Steen NE, Reichborn-Kjennerud T, Dale A, Stefánsson K, Djurovic S, Andreassen OA. Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder. Molecular Psychiatry. 2019eng
dc.identifier.issn1476-5578
dc.identifier.issn1359-4184
dc.identifier.urihttps://hdl.handle.net/1956/23296
dc.description.abstractDifferential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, genetic correlation reported for these disorders is low and non-significant. Here we aimed to better characterize the genetic architecture of these disorders utilizing recent large genome-wide association studies (GWAS). We analyzed independent GWAS summary statistics for ADHD (19,099 cases and 34,194 controls) and BD (20,352 cases and 31,358 controls) applying the conditional/conjunctional false discovery rate (condFDR/conjFDR) statistical framework that increases the power to detect novel phenotype-specific and shared loci by leveraging the combined power of two GWAS. We observed cross-trait polygenic enrichment for ADHD conditioned on associations with BD, and vice versa. Leveraging this enrichment, we identified 19 novel ADHD risk loci and 40 novel BD risk loci at condFDR <0.05. Further, we identified five loci jointly associated with ADHD and BD (conjFDR < 0.05). Interestingly, these five loci show concordant directions of effect for ADHD and BD. These results highlight a shared underlying genetic risk for ADHD and BD which may help to explain the high comorbidity rates and difficulties in differentiating between ADHD and BD in the clinic. Improving our understanding of the underlying genetic architecture of these disorders may aid in the development of novel stratification tools to help reduce these diagnostic difficulties.en_US
dc.language.isoengeng
dc.publisherNatureeng
dc.titleIdentification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorderen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-12-05T09:52:24Z
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2019 The Author(s)
dc.identifier.doihttps://doi.org/10.1038/s41380-019-0613-z
dc.identifier.cristin1757004
dc.source.journalMolecular Psychiatry
dc.relation.projectAndre: SKGJ-2011-36
dc.relation.projectNorges forskningsråd: 226971
dc.relation.projectAndre: EB00790
dc.relation.projectAndre: NS057198
dc.relation.projectNorges forskningsråd: 229129
dc.relation.projectNorges forskningsråd: 213837
dc.relation.projectNorges forskningsråd: 223273
dc.relation.projectHelse Sør-Øst RHF: 2013-123


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