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dc.contributor.authorSkjellerudsveen, Berit M.en_US
dc.contributor.authorOmdal, Roalden_US
dc.contributor.authorGrimstad, Toreen_US
dc.date.accessioned2020-08-06T11:52:02Z
dc.date.available2020-08-06T11:52:02Z
dc.date.issued2019
dc.PublishedSkjellerudsveen, Omdal R, Grimstad T. Fatigue in celiac disease: A review of the literature. Journal of Gastroenterology and Hepatology Open (JGH Open). 2019;3(3):242-248eng
dc.identifier.issn2397-9070
dc.identifier.urihttps://hdl.handle.net/1956/23516
dc.description.abstractFatigue is increasingly recognized as a significant problem in patients with chronic inflammatory and autoimmune diseases. In celiac disease, a chronic immune‐mediated disease triggered by dietary gluten, conflicting opinions exist regarding both the size of the problem and the effect of a gluten‐free diet (GFD) on fatigue. We reviewed the existing literature regarding fatigue in celiac disease. We conducted a systematic search in the Embase, Ovid Medline, and Cochrane databases using subject terms from controlled vocabularies. Articles were reviewed based on language, type of article, title, and abstract or full text. Eighteen articles were finally selected for review. Fatigue was significantly greater in patients with celiac disease compared to healthy control subjects. Fatigue prevalence ranged from 8 to 100%. Fatigue severity was assessed in six studies. The fatigue visual analogue scale was the most frequently used fatigue instrument with scores from 57 to 79 prior to starting a GFD and from 39 to 59 in patients on a GFD. Seven studies investigated the effect of a GFD on fatigue, including five studies that reported less fatigue while on the diet and two studies that showed no significant difference. This review concludes that fatigue is a substantial complaint in patients with celiac disease. A GFD seems to reduce fatigue, but existing data are limited.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution-Non Commercial CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/eng
dc.titleFatigue in celiac disease: A review of the literatureen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-12-12T10:54:46Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2019 The Authors
dc.identifier.doihttps://doi.org/10.1002/jgh3.12134
dc.identifier.cristin1732933
dc.source.journalJournal of Gastroenterology and Hepatology Open (JGH Open)


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