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dc.contributor.authorMykland, Martin Syvertsenen_US
dc.contributor.authorBjørk, Marte-Heleneen_US
dc.contributor.authorStjern, Mariten_US
dc.contributor.authorOmland, Petter Moeen_US
dc.contributor.authorUglem, Martinen_US
dc.contributor.authorSand, Tronden_US
dc.PublishedMykland MS, Bjørk MH, Stjern M, Omland PM, Uglem M, Sand T. Fluctuations of sensorimotor processing in migraine: A controlled longitudinal study of beta event related desynchronization. The Journal of Headache and Pain. 2019;20:77eng
dc.description.abstractBackground: The migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other well-known premonitory CNS-symptoms. In the present study we measured EEG-activation to non-painful motor and sensorimotor tasks in the different phases of the migraine cycle by longitudinal measurements of beta event related desynchronization (beta-ERD). Methods: We recorded electroencephalography (EEG) of 41 migraine patients and 31 healthy controls. Each subject underwent three EEG recordings on three different days with classification of each EEG recording according to the actual migraine phase. During each recording, subjects performed one motor and one sensorimotor task with the flexion-extension movement of the right wrist. Results: Migraine patients had significantly increased beta-ERD and higher baseline beta power at the contralateral C3 electrode overlying the primary sensorimotor cortex in the preictal phase compared to the interictal phase. We found no significant differences in beta-ERD or baseline beta power between interictal migraineurs and controls. Conclusion: Increased preictal baseline beta activity may reflect a decrease in pre-activation in the sensorimotor cortex. Altered pre-activation may lead to changes in thresholds for inhibitory responses and increased beta-ERD response, possibly reflecting a generally increased preictal cortical responsivity in migraine. Cyclic fluctuations in the activity of second- and third-order afferent somatosensory neurons, and their associated cortical and/or thalamic interneurons, may accordingly also be a central part of the migraine pathophysiology.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.titleFluctuations of sensorimotor processing in migraine: A controlled longitudinal study of beta event related desynchronizationen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors
dc.source.journalThe Journal of Headache and Pain

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