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dc.contributor.authorEspedal, Heidien_US
dc.contributor.authorFonnes, Tinaen_US
dc.contributor.authorFasmer, Kristine Eldeviken_US
dc.contributor.authorKrakstad, Camillaen_US
dc.contributor.authorHaldorsen, Ingfrid S.en_US
dc.PublishedEspedal H, Fonnes T, Fasmer KE, Krakstad C, Haldorsen IS. Imaging of preclinical endometrial cancer models for monitoring tumor progression and response to targeted therapy. Cancers. 2019;11(12):1885eng
dc.description.abstractEndometrial cancer is the most common gynecologic malignancy in industrialized countries. Most patients are cured by surgery; however, about 15% of the patients develop recurrence with limited treatment options. Patient-derived tumor xenograft (PDX) mouse models represent useful tools for preclinical evaluation of new therapies and biomarker identification. Preclinical imaging by magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), single-photon emission computed tomography (SPECT) and optical imaging during disease progression enables visualization and quantification of functional tumor characteristics, which may serve as imaging biomarkers guiding targeted therapies. A critical question, however, is whether the in vivo model systems mimic the disease setting in patients to such an extent that the imaging biomarkers may be translatable to the clinic. The primary objective of this review is to give an overview of current and novel preclinical imaging methods relevant for endometrial cancer animal models. Furthermore, we highlight how these advanced imaging methods depict pathogenic mechanisms important for tumor progression that represent potential targets for treatment in endometrial cancer.en_US
dc.rightsAttribution CC BYeng
dc.titleImaging of preclinical endometrial cancer models for monitoring tumor progression and response to targeted therapyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors

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