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dc.contributor.authorMortensen, Rasmusen_US
dc.contributor.authorClemmensen, Helena Stranden_US
dc.contributor.authorWoodworth, Joshua S.en_US
dc.contributor.authorTherkelsen, Marie Louiseen_US
dc.contributor.authorMustafa, Tehminaen_US
dc.contributor.authorTonby, Kristianen_US
dc.contributor.authorJenum, Synneen_US
dc.contributor.authorAgger, Else Marieen_US
dc.contributor.authorDyrhol-Riise, Anne Maen_US
dc.contributor.authorAndersen, Peteren_US
dc.PublishedMortensen R, Clemmensen, Woodworth, Therkelsen, Mustafa T, Tonby K, Jenum S, Agger EM, Dyrhol-Riise AM, Andersen P. Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. Communications Biology. 2019;2:288eng
dc.description.abstractTuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health emergency and host-directed therapy as adjunct to antibiotic treatment has gained increased interest. Cyclooxygenase inhibitors (COXi) are frequently used drugs to alleviate tuberculosis related symptoms. Mouse studies of acute intravenous Mtb infection have suggested a potential benefit of COXi for host-directed therapy. Here we show that COXi treatment (ibuprofen and celecoxib) is detrimental to Mtb control in different mouse models of respiratory infection. This effect links to impairments of the Type-1 helper (Th1) T-cell response as CD4 T-cells in COXi-treated animals have significantly decreased Th1 differentiation, reduced IFNγ expression and decreased protective capacity upon adoptive transfer. If confirmed in clinical trials, these findings could have major impact on global health and question the use of COXi for host-directed therapy.en_US
dc.publisherNature Researcheng
dc.rightsAttribution CC BYeng
dc.titleCyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged miceen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalCommunications Biology
dc.relation.projectNorges forskningsråd: 234493

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