Sars International Centre for Marine Molecular Biology
Recent Submissions
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Heterogenic Origin of Micro RNAs in Atlantic Salmon (Salmo salar) Seminal Plasma
(Journal article; Peer reviewed, 2020)The origin and contribution of seminal plasma RNAs into the whole semen RNA repertoire are poorly known, frequently being overlooked or neglected. In this study, we used high-throughput sequencing and RT-qPCR to profile ... -
Transcriptional adaptation in caenorhabditis elegans
(Journal article; Peer reviewed, 2020-01)Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed ... -
Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts
(Journal article; Peer reviewed, 2019-11-13)Metazoans have evolved a great variety of life histories in response to environmental conditions. A unique example is encountered in dicyemid mesozoans. In addition to a highly simplified adult body comprising only ~ 30 ... -
Active mode of excretion across digestive tissues predates the origin of excretory organs
(Journal article; Peer reviewed, 2019)Most bilaterian animals excrete toxic metabolites through specialized organs, such as nephridia and kidneys, which share morphological and functional correspondences. In contrast, excretion in non-nephrozoans is largely ... -
CNEr: A toolkit for exploring extreme noncoding conservation
(Journal article; Peer reviewed, 2019-08-26)Conserved Noncoding Elements (CNEs) are elements exhibiting extreme noncoding conservation in Metazoan genomes. They cluster around developmental genes and act as long-range enhancers, yet nothing that we know about their ... -
Hox gene expression in postmetamorphic juveniles of the brachiopod Terebratalia transversa
(Journal article; Peer reviewed, 2019-01-08)Background: Hox genes encode a family of homeodomain containing transcription factors that are clustered together on chromosomes of many Bilateria. Some bilaterian lineages express these genes during embryogenesis in spatial ... -
Evolutionary Implications of the microRNA- and piRNA Complement of Lepidodermella squamata (Gastrotricha)
(Journal article; Peer reviewed, 2019-02-22)Gastrotrichs—’hairy bellies’—are microscopic free-living animals inhabiting marine and freshwater habitats. Based on morphological and early molecular analyses, gastrotrichs were placed close to nematodes, but recent ... -
Gap junction-dependent coordination of intercellular calcium signalling in the developing appendicularian tunicate Oikopleura dioica
(Journal article; Peer reviewed, 2019)We characterized spontaneous Ca2+ signals in Oikopleura dioica embryos from pre-fertilization to gastrula stages following injection of GCaMP6 mRNA into unfertilized eggs. The unfertilized egg exhibited regular, transient ... -
Hox gene expression during development of the phoronid Phoronopsis harmeri
(Journal article; Peer reviewed, 2020)Background: Phoronida is a small group of marine worm-like suspension feeders, which together with brachiopods and bryozoans form the clade Lophophorata. Although their development is well studied on the morphological ... -
Exciting times to study the identity and evolution of cell types
(Journal article, 2019)The EMBO/EMBL Symposium on ‘The Identity and Evolution of Cell Types’ took place in Heidelberg, Germany, on 15-19 May 2019. The symposium, which brought together a diverse group of speakers addressing a wide range of ... -
Five New Species of Guimaraesiella (Phthiraptera: Ischnocera) from Broadbills (Aves: Passeriformes: Calyptomenidae: Eurylaimidae)
(Journal article; Peer reviewed, 2019)Five new species of Guimaraesiella Eichler, 1949 are described and illustrated from hosts in the Eurylaimidae and Calyptomenidae. They are Guimaraesiella corydoni n. sp. from Corydon sumatranus laoensisMeyer de Schauensee, ... -
The architecture of cell differentiation in choanoflagellates and sponge choanocytes
(Journal article; Peer reviewed, 2019-04-12)Although collar cells are conserved across animals and their closest relatives, the choanoflagellates, little is known about their ancestry, their subcellular architecture, or how they differentiate. The choanoflagellate ... -
The Birth and Death of Toxins with Distinct Functions: A Case Study in the Sea Anemone Nematostella
(Journal article; Peer reviewed, 2019-05-27)The cnidarian Nematostella vectensis has become an established lab model, providing unique opportunities for venom evolution research. The Nematostella venom system is multimodal: involving both nematocytes and ectodermal ... -
Automated behavioural analysis reveals the basic behavioural repertoire of the urochordate Ciona intestinalis
(Journal article; Peer reviewed, 2019-02-20)Quantitative analysis of animal behaviour in model organisms is becoming an increasingly essential approach for tackling the great challenge of understanding how activity in the brain gives rise to behaviour. Here we used ... -
A non-bilaterian perspective on the development and evolution of animal digestive systems
(Journal article; Peer reviewed, 2019-08-07)Digestive systems and extracellular digestion are key animal features, but their emergence during early animal evolution is currently poorly understood. As the last common ancestor of non-bilaterian animal groups (sponges, ... -
A novel measure of non-coding genome conservation identifies genomic regulatory blocks within primates
(Journal article; Peer reviewed, 2018-12-07)Motivation Clusters of extremely conserved non-coding elements (CNEs) mark genomic regions devoted to cis-regulation of key developmental genes in Metazoa. We have recently shown that their span coincides with that of ... -
Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence
(Journal article; Peer reviewed, 2019-03-15)The four Caenorhabditis species C. elegans, C. briggsae, C. remanei and C. brenneri show more divergence at the genomic level than humans compared to mice (Stein et al., 2003; Cutter et al., 2006, 2008). However, the ... -
Transcription start site mapping using super-low input carrier-CAGE
(Journal article; Peer reviewed, 2019-06-26)Cap analysis of gene expression (CAGE) is a method used for single-nucleotide resolution detection of RNA polymerase II transcription start sites (TSSs). Accurate detection of TSSs enhances identification and discovery of ... -
Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR
(Journal article; Peer reviewed, 2019)Background: In phylogenetically diverse organisms, the 5′ ends of a subset of mRNAs are trans-spliced with a spliced leader (SL) RNA. The functions of SL trans-splicing, however, remain largely enigmatic. Results: We ... -
Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks
(Journal article; Peer reviewed, 2019)Recent genome-wide association studies have identified numerous loci associated with neuropsychiatric disorders. The majority of these are in non-coding regions, and are commonly assigned to the nearest gene along the ...
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