Recent Submissions

  • Comprehensive analysis of locomotion dynamics in the protochordate Ciona intestinalis reveals how neuromodulators flexibly shape its behavioral repertoire 

    Athira, Athira; Dondorp, Daniel; Rudolf, Jerneja; Peytral, Olivia; Chatzigeorgiou, Marios (Journal article; Peer reviewed, 2022)
    Vertebrate nervous systems can generate a remarkable diversity of behaviors. However, our understanding of how behaviors may have evolved in the chordate lineage is limited by the lack of neuroethological studies leveraging ...
  • Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis 

    Gahan, James Michael; Kouzel, Ivan; Ormevik Jansen, Kamilla; Burkhardt, Pawel; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)
    Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ...
  • Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells 

    Bernadskaya, Yelena Y.; Yue, Haicen; Copos, Calina; Christiaen, Lionel; Mogilner, Alex (Journal article; Peer reviewed, 2021)
    Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale ...
  • Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin 

    Weiss, Felix D.; Calderon, Lesly; Wang, Yi-Fang; Georgieva, Radina; Guo, Ya; Cvetesic, Nevena; Kaur, Maninder; Dharmalingam, Gopuraja; Krantz, Ian D.; Lenhard, Boris; Fisher, Amanda G.; Merkenschlager, Matthias (Journal article; Peer reviewed, 2021)
    Cornelia de Lange Syndrome (CdLS) is a human developmental disorder caused by mutations that compromise the function of cohesin, a major regulator of 3D genome organization. Cognitive impairment is a universal and as yet ...
  • Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data 

    Kolar, Kushal; Dondorp, Daniel; Zwiggelaar, Jordi Cornelis; Høyer, Jørgen; Chatzigeorgiou, Marios (Journal article; Peer reviewed, 2021)
    Calcium imaging is an increasingly valuable technique for understanding neural circuits, neuroethology, and cellular mechanisms. The analysis of calcium imaging data presents challenges in image processing, data organization, ...
  • The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes 

    Vöcking, Oliver; Leclère, Lucas; Hausen, Harald (Journal article; Peer reviewed, 2021-11-29)
    Background: The process of photoreception in most animals depends on the light induced isomerization of the chromophore retinal, bound to rhodopsin. To re-use retinal, the all-trans-retinal form needs to be re-isomerized ...
  • Choanoflagellates and the ancestry of neurosecretory vesicles 

    Göhde, Ronja Alica Angelika; Naumann, Benjamin; Laundon, Davis; Imig, Cordelia; McDonald, Kent; Cooper, Benjamin H.; Varoqueaux, Frédérique; Fasshauer, Dirk; Burkhardt, Pawel (Journal article; Peer reviewed, 2021)
    Neurosecretory vesicles are highly specialized trafficking organelles that store neurotransmitters that are released at presynaptic nerve endings and are, therefore, important for animal cell–cell signalling. Despite ...
  • Molecular evidence for a single origin of ultrafiltration-based excretory organs 

    Gasiorowski, Ludwik; Andrikou, Carmen; Bump, Paul; Lowe, Christopher J.; Janssen, Ralf; Budd, Graham E.; Hejnol, Andreas (Journal article; Peer reviewed, 2021)
    Excretion is an essential physiological process, carried out by all living organisms, regardless of their size or complexity.1, 2, 3 Both protostomes (e.g., flies and flatworms) and deuterostomes (e.g., humans and sea ...
  • Extreme Levels of Ocean Acidification Restructure the Plankton Community and Biogeochemistry of a Temperate Coastal Ecosystem: A Mesocosm Study 

    Spisla, Carsten; Taucher, Jan; Bach, Lennart T; Haunost, Mathias; Boxhammer, Tim; King, Andrew L; Jenkins, Bettany D.; Wallace, Joselynn R.; Ludwig, Andrea; Meyer, Jana; Stange, Paul; Minutolo, Fabrizio; Lohbeck, Kai T.; Nauendorf, Alice; Kalter, Verena; Lischka, Silke; Sswat, Michael; Dörner, Isabel; Ismar-Rebitz, Stefanie M. H.; Aberle, Nicole; Yong, Jaw C; Bouquet, Jean-Marie; Lechtenbörger, Anna K.; Kohnert, Peter; Krudewig, Michael; Riebesell, Ulf (Journal article; Peer reviewed, 2021)
    The oceans’ uptake of anthropogenic carbon dioxide (CO2) decreases seawater pH and alters the inorganic carbon speciation – summarized in the term ocean acidification (OA). Already today, coastal regions experience episodic ...
  • Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers 

    Cerullo, Antonio R.; Lai, Tsoi Ying; Allam, Bassem; Baer, Alexander; Barnes, W. Jon P.; Barrientos, Zaidett; Deheyn, Dimitri D.; Fudge, Douglas S.; Gould, John A.; Harrington, Matthew J.; Holford, Mandë; Hung, Chia-Suei; Jain, Gaurav; Mayer, Georg; Medina, Mónica; Monge-Nájera, Julian; Napolitano, Tanya; Pales Espinosa, Emmanuelle; Schmidt, Stephan; Thompson, Eric; Braunschweig, Adam B. (Journal article; Peer reviewed, 2020)
    The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the ...
  • Oikopleura 

    Glover, Joel (Journal article; Peer reviewed, 2020)
  • Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels 

    Lynagh, Timothy (Journal article; Peer reviewed, 2020)
    Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride ...
  • Functional annotation of human long noncoding RNAs via molecular phenotyping 

    Ramilowski, Jordan; Yip, Chiu Wai Mickey; Agrawal, Saumya; Chang, Jen-Chien; Ciani, Yari; Kulakovskiy, Ivan; Mendez, Mickaël; Ching Ooi, Jasmine Li; Ouyang, John F; Parkinson, Nick; Kasukawa, Takeya; Kauppinen, Sakari; Kere, Juha; Lenhard, Boris; Schneider, Claudio; Suzuki, Harukazu; Yagi, Ken; De Hoon, Michiel J L; Shin, Jay W; Piero, Carninci (Journal article; Peer reviewed, 2020)
    Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...
  • Conservative route to genome compaction in a miniature annelid 

    Martin-Duran, José M.; Vellutini, Bruno Cossermelli; Marletaz, Ferdinand; Cetrangolo, Viviana; Cvetesic, Nevena; Thiel, Daniel; Henriet, Simon; Grau-Bové, Xavier; Carrillo-Baltodano, Allan M.; Gu, Wenjia; Kerbl, Alexandra; Marquez, Yamile; Bekkouche, Nicolas; Chourrout, Daniel; Gómez-Skarmeta, José Luis; Irimia, Manuel; Lenhard, Boris; Worsaae, Katrine; Hejnol, Andreas (Journal article; Peer reviewed, 2021)
    The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ...
  • Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom 

    Sachkova, Maria; Landau, Morani; Surm, Joachim M.; Macrander, Jason; Singer, Shir A.; Reitzel, Adam M.; Moran, Yehu (Journal article; Peer reviewed, 2020)
    The sea anemone Nematostella vectensis (Anthozoa, Cnidaria) is a powerful model for characterizing the evolution of genes functioning in venom and nervous systems. Although venom has evolved independently numerous times ...
  • Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods 

    Lewis, Samuel H.; Ross, Laura; Bain, Stevie A.; Pahita, Eleni; Smith, Stephen A.; Cordaux, Richard; Miska, Eric A.; Lenhard, Boris; Jiggins, Francis M.; Sarkies, Peter (Journal article; Peer reviewed, 2020)
    Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters ...
  • Peptide Inhibitors of the α‑Cobratoxin−Nicotinic Acetylcholine Receptor Interaction 

    Lynagh, Timothy; Kiontke, Stephan; Meyhoff-Madsen, Maria; Gless, Bengt H.; Johannesen, Jónas; Kattelmann, Sabrina; Christiansen, Anders; Dufva, Martin; Laustsen, Andreas H.; Devkota, Kanchan; Olsen, Christian A.; Kümmel, Daniel; Pless, Stephan Alexander; Lohse, Brian (Journal article; Peer reviewed, 2020)
    Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by ...
  • RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells 

    Kouzel, Ivan; Kehl, Alexander; Berger, Petya; Liashkovich, Ivan; Steil, Daniel; Makalowski, Wojciech; Suzuki, Yutaka; Pohlentz, Gottfried; Karch, Helge; Mellmann, Alexander C.; Müthing, Johannes (Journal article; Peer reviewed, 2020-03-18)
    The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial ...
  • NvPOU4/Brain3 Functions as a Terminal Selector Gene in the Nervous System of the Cnidarian Nematostella vectensis 

    Tourniere, Oceane Barbara; Dolan, David William Peter; Richards, Gemma Sian; Sunagar, Kartik; Columbus-Shenkar, Yaara Y; Moran, Yehu; Rentzsch, Fabian (Journal article; Peer reviewed, 2020-03)
    Terminal selectors are transcription factors that control the morphological, physiological, and molecular features that characterize distinct cell types. Here, we show that, in the sea anemone Nematostella vectensis, NvPOU4 ...
  • RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions 

    Bonetti, Alessandro; Agostini, Federico; Suzuki, Ana Maria; Hashimoto, Kosuke; Pascarella, Giovanni; Gimenez, Juliette; Roos, Leonie; Nash, Alex J.; Ghilotti, Marco; Cameron, Christopher J.  F.; Valentine, Matthew; Medvedeva, Yulia A.; Noguchi, Shuhei; Agirre, Eneritz; Kashi, Kaori; Samudyata, Samudyata; Luginbühl, Joachim; Cazzoli, Riccardo; Agrawal, Saumya; Luscombe, Nicholas M.; Blanchette, Mathieu; Kasukawa, Takeya; de Hoon, Michiel; Arner, Erik; Lenhard, Boris; Plessy, Charles; Castelo-Branco, Gonçalo; Orlando, Valerio; Carninci, Piero (Journal article; Peer reviewed, 2020)
    Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. ...

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