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Heterogenic Origin of Micro RNAs in Atlantic Salmon (Salmo salar) Seminal Plasma
(Journal article; Peer reviewed, 2020)The origin and contribution of seminal plasma RNAs into the whole semen RNA repertoire are poorly known, frequently being overlooked or neglected. In this study, we used high-throughput sequencing and RT-qPCR to profile ... -
Histone variant innovation in a rapidly evolving chordate lineage
(Peer reviewed; Journal article, 2011-07-15)Background: Histone variants alter the composition of nucleosomes and play crucial roles in transcription, chromosome segregation, DNA repair, and sperm compaction. Modification of metazoan histone variant lineages occurs ... -
Hox gene expression during development of the phoronid Phoronopsis harmeri
(Journal article; Peer reviewed, 2020)Background: Phoronida is a small group of marine worm-like suspension feeders, which together with brachiopods and bryozoans form the clade Lophophorata. Although their development is well studied on the morphological ... -
Hox gene expression in postmetamorphic juveniles of the brachiopod Terebratalia transversa
(Journal article; Peer reviewed, 2019-01-08)Background: Hox genes encode a family of homeodomain containing transcription factors that are clustered together on chromosomes of many Bilateria. Some bilaterian lineages express these genes during embryogenesis in spatial ... -
In Silico Detection of Sequence Variations Modifying Transcriptional Regulation
(Journal article; Peer reviewed, 2008-01-18)Identification of functional genetic variation associated with increased susceptibility to complex diseases can elucidate genes and underlying biochemical mechanisms linked to disease onset and progression. For genes linked ... -
Increased taxon sampling reveals thousands of hidden orthologs in flatworms
(Journal article; Peer reviewed, 2017)Gains and losses shape the gene complement of animal lineages and are a fundamental aspect of genomic evolution. Acquiring a comprehensive view of the evolution of gene repertoires is limited by the intrinsic limitations ... -
JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update
(Journal article; Peer reviewed, 2007-11-15)JASPAR is a popular open-access database for matrix models describing DNA-binding preferences for transcription factors and other DNA patterns. With its third major release, JASPAR has been expanded and equipped with ... -
The larval nervous system of the penis worm Priapulus caudatus (Ecdysozoa)
(Journal article; Peer reviewed, 2016-01)The origin and extreme diversification of the animal nervous system is a central question in biology. While most of the attention has traditionally been paid to those lineages with highly elaborated nervous systems (e.g. ... -
Lim homeobox genes in the Ctenophore Mnemiopsis leidyi: the evolution of neural cell type specification
(Journal article; Peer reviewed, 2012-01-13)Background: Nervous systems are thought to be important to the evolutionary success and diversification of metazoans, yet little is known about the origin of simple nervous systems at the base of the animal tree. Recent ... -
Mesodermal gene expression during the embryonic and larval development of the articulate brachiopod Terebratalia transversa
(Journal article; Peer reviewed, 2015-04-11)Background: Brachiopods undergo radial cleavage, which is distinct from the stereotyped development of closely related spiralian taxa. The mesoderm has been inferred to derive from the archenteron walls following gastrulation, ... -
MicroRNAs and essential components of the microRNA processing machinery are not encoded in the genome of the ctenophore Mnemiopsis leidyi
(Journal article; Peer reviewed, 2012-12-20)Background: MicroRNAs play a vital role in the regulation of gene expression and have been identified in every animal with a sequenced genome examined thus far, except for the placozoan Trichoplax. The genomic repertoires ... -
Molecular characterization of the apical organ of the anthozoan Nematostella vectensis
(Journal article; Peer reviewed, 2014-12-03)Apical organs are sensory structures present in many marine invertebrate larvae where they are considered to be involved in their settlement, metamorphosis and locomotion. In bilaterians they are characterised by a tuft ... -
Molecular evidence for a single origin of ultrafiltration-based excretory organs
(Journal article; Peer reviewed, 2021)Excretion is an essential physiological process, carried out by all living organisms, regardless of their size or complexity.1, 2, 3 Both protostomes (e.g., flies and flatworms) and deuterostomes (e.g., humans and sea ... -
Molecular patterning during the development of Phoronopsis harmeri reveals similarities to rhynchonelliform brachiopods
(Journal article; Peer reviewed, 2019)Background: Phoronids, rhynchonelliform and linguliform brachiopods show striking similarities in their embryonic fate maps, in particular in their axis specification and regionalization. However, although brachiopod ... -
Molecular regionalization in the compact brain of the meiofaunal annelid Dinophilus gyrociliatus (Dinophilidae)
(Journal article; Peer reviewed, 2016-08-30)Background: Annelida is a morphologically diverse animal group that exhibits a remarkable variety in nervous system architecture (e.g., number and location of longitudinal cords, architecture of the brain). Despite this ... -
Morphogenesis underlying the development of the everted teleost telencephalon
(Peer reviewed; Journal article, 2012-09-18)Background: Although the mechanisms underlying brain patterning and regionalization are very much conserved, the morphology of different brain regions is extraordinarily variable across vertebrate phylogeny. This is ... -
Morphological investigations of posttraumatic regeneration in Timarete cf. punctata (Annelida: Cirratulidae)
(Journal article; Peer reviewed, 2015-08-06)Introduction: Annelids exhibit great regenerative abilities, which are mainly used after injury or during reproduction. These lophotrochozoans thus represent excellent models for regeneration research. However, detailed ... -
A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus
(Journal article; Peer reviewed, 2019-07-10)Background The trochozoan excitatory peptide (EP) and its ortholog, the arthropod CCHamide, are neuropeptides that are only investigated in very few animal species. Previous studies on different trochozoan species focused ... -
A non-bilaterian perspective on the development and evolution of animal digestive systems
(Journal article; Peer reviewed, 2019-08-07)Digestive systems and extracellular digestion are key animal features, but their emergence during early animal evolution is currently poorly understood. As the last common ancestor of non-bilaterian animal groups (sponges, ... -
A novel measure of non-coding genome conservation identifies genomic regulatory blocks within primates
(Journal article; Peer reviewed, 2018-12-07)Motivation Clusters of extremely conserved non-coding elements (CNEs) mark genomic regions devoted to cis-regulation of key developmental genes in Metazoa. We have recently shown that their span coincides with that of ...