Browsing Sars International Centre for Marine Molecular Biology by Title
Now showing items 97-116 of 137
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A novel measure of non-coding genome conservation identifies genomic regulatory blocks within primates
(Journal article; Peer reviewed, 2018-12-07)Motivation Clusters of extremely conserved non-coding elements (CNEs) mark genomic regions devoted to cis-regulation of key developmental genes in Metazoa. We have recently shown that their span coincides with that of ... -
Nuclear genomic signals of the “microturbellarian” roots of platyhelminth evolutionary innovation
(Journal article; Peer reviewed, 2015-03-12)Flatworms number among the most diverse invertebrate phyla and represent the most biomedically significant branch of the major bilaterian clade Spiralia, but to date, deep evolutionary relationships within this group have ... -
NvPOU4/Brain3 Functions as a Terminal Selector Gene in the Nervous System of the Cnidarian Nematostella vectensis
(Journal article; Peer reviewed, 2020-03)Terminal selectors are transcription factors that control the morphological, physiological, and molecular features that characterize distinct cell types. Here, we show that, in the sea anemone Nematostella vectensis, NvPOU4 ... -
NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis
(Journal article; Peer reviewed, 2023)Neurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal tissue is, in contrast, poorly understood. Here we use the cnidarian ... -
Oikopleura
(Journal article; Peer reviewed, 2020) -
Owenia fusiformis – a basally branching annelid suitable for studying ancestral features of annelid neural development
(Journal article; Peer reviewed, 2016-06-16)Background Comparative investigations on bilaterian neurogenesis shed light on conserved developmental mechanisms across taxa. With respect to annelids, most studies focus on taxa deeply nested within the annelid tree, ... -
Pairwise comparisons across species are problematic when analyzing functional genomic data
(Journal article; Peer reviewed, 2018-01-04)There is considerable interest in comparing functional genomic data across species. One goal of such work is to provide an integrated understanding of genome and phenotype evolution. Most comparative functional genomic ... -
Peptide Inhibitors of the α‑Cobratoxin−Nicotinic Acetylcholine Receptor Interaction
(Journal article; Peer reviewed, 2020)Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by ... -
Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians
(Journal article; Peer reviewed, 2015-12-22)Background: Development of cerebral eyes is generally based on fine-tuned networks and closely intertwined with the formation of brain and head. Consistently and best studied in insects and vertebrates, many signaling ... -
The Potent Respiratory System of Osedax mucofloris (Siboglinidae, Annelida) - A Prerequisite for the Origin of Bone-Eating Osedax?
(Peer reviewed; Journal article, 2012-04-25)Members of the conspicuous bone-eating genus, Osedax, are widely distributed on whale falls in the Pacific and Atlantic Oceans. These gutless annelids contain endosymbiotic heterotrophic bacteria in a branching root system ... -
Prediction of CpG-island function: CpG clustering vs. sliding-window methods
(Peer reviewed; Journal article, 2010-05-26)Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ... -
The premetazoan ancestry of the synaptic toolkit and appearance of first neurons
(Journal article; Peer reviewed, 2022)Neurons, especially when coupled with muscles, allow animals to interact with and navigate through their environment in ways unique to life on earth. Found in all major animal lineages except sponges and placozoans, nervous ... -
Profile analysis and prediction of tissue-specific CpG island methylation classes
(Journal article; Peer reviewed, 2009-04-21)Background: The computational prediction of DNA methylation has become an important topic in the recent years due to its role in the epigenetic control of normal and cancer-related processes. While previous prediction ... -
RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells
(Journal article; Peer reviewed, 2020-03-18)The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial ... -
RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions
(Journal article; Peer reviewed, 2020)Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. ... -
Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells
(Journal article; Peer reviewed, 2023)Purinergic P2X7 receptors (P2X7) have now been proven to play an important role and represent an important therapeutic target in many pathological conditions including neurodegeneration. Here, we investigated the impact ... -
Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
(Journal article; Peer reviewed, 2015-10-06)Notch signalling, SoxB and Group A bHLH ‘proneural’ genes are conserved regulators of the neurogenic program in many bilaterians. However, the ancestry of their functions and interactions is not well understood. We address ... -
Regulatory RNA at the root of animals: dynamic expression of developmental lincRNAs in the calcisponge Sycon ciliatum
(Journal article; Peer reviewed, 2015-12-23)Long non-coding RNAs (lncRNAs) play important regulatory roles during animal development, and it has been hypothesized that an RNA-based gene regulation was important for the evolution of developmental complexity in animals. ... -
Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes
(Journal article; Peer reviewed, 2007-10-31)A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovered areas around ... -
The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes
(Journal article; Peer reviewed, 2021-11-29)Background: The process of photoreception in most animals depends on the light induced isomerization of the chromophore retinal, bound to rhodopsin. To re-use retinal, the all-trans-retinal form needs to be re-isomerized ...