Now showing items 99-107 of 107

    • Translog, a web browser for studying the expression divergence of homologous genes 

      Dong, Xianjun; Akalin, Altuna; Sharma, Yogita; Lenhard, Boris (Journal article; Peer reviewed, 2010-01-18)
      Background: Increasing amount of data from comparative genomics, and newly developed technologies producing accurate gene expression data facilitate the study of the expression divergence of homologous genes. Previous ...
    • Transposon mediated transgenesis in a marine invertebrate chordate: Ciona intestinalis 

      Sasakura, Yasunori; Oogai, Yuichi; Matsuoka, Terumi; Satoh, Nori; Awazu, Satoko (Journal article; Peer reviewed, 2007-10-31)
      Achievement of transposon mediated germline transgenesis in a basal chordate, Ciona intestinalis, is discussed. A Tc1/mariner superfamily transposon, Minos, has excision and transposition activities in Ciona. Minos enables ...
    • Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence 

      Memar, Nadin; Schiemann, Sabrina; Hennig, Christian; Findeis, Daniel; Conradt, Barbara; Schnabel, Ralf (Journal article; Peer reviewed, 2019-03-15)
      The four Caenorhabditis species C. elegans, C. briggsae, C. remanei and C. brenneri show more divergence at the genomic level than humans compared to mice (Stein et al., 2003; Cutter et al., 2006, 2008). However, the ...
    • Ultrastructural correlates of enhanced norepinephrine and neuropeptide y cotransmission in the spontaneously hypertensive rat brain 

      Kourtesis, Ioannis; Kasparov, Sergey; Verkade, Paul; Teschemacher, Anja G. (Journal article; Peer reviewed, 2015-10-29)
      The spontaneously hypertensive rat (SHR) replicates many clinically relevant features of human essential hypertension and also exhibits behavioral symptoms of attention-deficit/hyperactivity disorder and dementia. The SHR ...
    • Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks 

      Barešić, Anja; Nash, Alexander Jolyon; Dahoun, Tarik; Howes, Oliver; Lenhard, Boris (Journal article; Peer reviewed, 2019)
      Recent genome-wide association studies have identified numerous loci associated with neuropsychiatric disorders. The majority of these are in non-coding regions, and are commonly assigned to the nearest gene along the ...
    • A unified phylogeny-based nomenclature for histone variants 

      Talbert, Paul B.; Ahmad, Kami; Almouzni, Geneviève; Ausió, Juan; Berger, Frederic; Thompson, Eric M.; Bhalla, Prem L.; Bonner, William M.; Cande, W. Zacheus; Chadwick, Brian P.; Chan, Simon W. L.; Cross, George A. M.; Cui, Liwang; Dimitrov, Stefan I.; Doenecke, Detlef; Eirin-López, José M.; Gorovsky, Martin A.; Hake, Sandra B.; Hamkalo, Barbara A.; Holec, Sarah; Jacobsen, Steven E.; Kamieniarz, Kinga; Khochbin, Saadi; Ladurner, Andreas G.; Landsman, David; Latham, John A.; Loppin, Benjamin; Malik, Harmit S.; Marzluff, William F.; Pehrson, John R.; Postberg, Jan; Schneider, Robert; Singh, Mohan B.; Smith, M. M.; Torres-Padilla, Maria-Elena; Tremethick, David J.; Turner, Bryan M.; Waterborg, Jakob H.; Wollmann, Heike; Yelagandula, Ramesh; Zhu, Bing; Henikoff, Steven (Peer reviewed; Journal article, 2012-06-21)
      Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions for ...
    • The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution 

      Hausen, Harald; Döring, Clemens; Kumar, Suman; Tumu, Sharat Chandra; Kourtesis, Ioannis (Journal article; Peer reviewed, 2020)
      Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology. First ...
    • Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods 

      Lewis, Samuel H.; Ross, Laura; Bain, Stevie A.; Pahita, Eleni; Smith, Stephen A.; Cordaux, Richard; Miska, Eric A.; Lenhard, Boris; Jiggins, Francis M.; Sarkies, Peter (Journal article; Peer reviewed, 2020)
      Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters ...
    • Xenacoelomorpha's significance for understanding bilaterian evolution 

      Hejnol, Andreas; Pang, Kevin Scott (Journal article; Peer reviewed, 2016-08)
      The Xenacoelomorpha, with its phylogenetic position as sister group of the Nephrozoa (Protostomia + Deuterostomia), plays a key-role in understanding the evolution of bilaterian cell types and organ systems. Current studies ...