Now showing items 94-107 of 107

    • Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom 

      Sachkova, Maria; Landau, Morani; Surm, Joachim M.; Macrander, Jason; Singer, Shir A.; Reitzel, Adam M.; Moran, Yehu (Journal article; Peer reviewed, 2020)
      The sea anemone Nematostella vectensis (Anthozoa, Cnidaria) is a powerful model for characterizing the evolution of genes functioning in venom and nervous systems. Although venom has evolved independently numerous times ...
    • Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR 

      Danks, Gemma Barbara; Galbiati, Heloisa; Raasholm, Martina; Torres Cleuren, Yamila Nicole; Valen, Eivind; Navratilova, Pavla; Thompson, Eric (Journal article; Peer reviewed, 2019)
      Background: In phylogenetically diverse organisms, the 5′ ends of a subset of mRNAs are trans-spliced with a spliced leader (SL) RNA. The functions of SL trans-splicing, however, remain largely enigmatic. Results: We ...
    • Transcription start site mapping using super-low input carrier-CAGE 

      Cvetesic, Nevena; Pahita, Elena; Lenhard, Boris (Journal article; Peer reviewed, 2019-06-26)
      Cap analysis of gene expression (CAGE) is a method used for single-nucleotide resolution detection of RNA polymerase II transcription start sites (TSSs). Accurate detection of TSSs enhances identification and discovery of ...
    • Transcriptional adaptation in caenorhabditis elegans 

      Serobyan, Vahan; Kontarakis, Zacharias; El-Brolosy, Mohamed A.; Welker, Jordan M.; Tolstenkov, Oleg; Saadeldein, Amr M.; Retzer, Nicholas; Gottschalk, Alexander; Wehman, Ann M; Stainier, Didier YR (Journal article; Peer reviewed, 2020-01)
      Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed ...
    • Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae, Porifera) 

      Borisenko, Ilya E.; Adamska, Maja; Tokina, Daria B.; Ereskovsky, Alexander V. (Journal article; Peer reviewed, 2015-08-25)
      The ability to regenerate is widespread in the animal kingdom, but the regenerative capacities and mechanisms vary widely. To understand the evolutionary history of the diverse regeneration mechanisms, the regeneration ...
    • Translog, a web browser for studying the expression divergence of homologous genes 

      Dong, Xianjun; Akalin, Altuna; Sharma, Yogita; Lenhard, Boris (Journal article; Peer reviewed, 2010-01-18)
      Background: Increasing amount of data from comparative genomics, and newly developed technologies producing accurate gene expression data facilitate the study of the expression divergence of homologous genes. Previous ...
    • Transposon mediated transgenesis in a marine invertebrate chordate: Ciona intestinalis 

      Sasakura, Yasunori; Oogai, Yuichi; Matsuoka, Terumi; Satoh, Nori; Awazu, Satoko (Journal article; Peer reviewed, 2007-10-31)
      Achievement of transposon mediated germline transgenesis in a basal chordate, Ciona intestinalis, is discussed. A Tc1/mariner superfamily transposon, Minos, has excision and transposition activities in Ciona. Minos enables ...
    • Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence 

      Memar, Nadin; Schiemann, Sabrina; Hennig, Christian; Findeis, Daniel; Conradt, Barbara; Schnabel, Ralf (Journal article; Peer reviewed, 2019-03-15)
      The four Caenorhabditis species C. elegans, C. briggsae, C. remanei and C. brenneri show more divergence at the genomic level than humans compared to mice (Stein et al., 2003; Cutter et al., 2006, 2008). However, the ...
    • Ultrastructural correlates of enhanced norepinephrine and neuropeptide y cotransmission in the spontaneously hypertensive rat brain 

      Kourtesis, Ioannis; Kasparov, Sergey; Verkade, Paul; Teschemacher, Anja G. (Journal article; Peer reviewed, 2015-10-29)
      The spontaneously hypertensive rat (SHR) replicates many clinically relevant features of human essential hypertension and also exhibits behavioral symptoms of attention-deficit/hyperactivity disorder and dementia. The SHR ...
    • Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks 

      Barešić, Anja; Nash, Alexander Jolyon; Dahoun, Tarik; Howes, Oliver; Lenhard, Boris (Journal article; Peer reviewed, 2019)
      Recent genome-wide association studies have identified numerous loci associated with neuropsychiatric disorders. The majority of these are in non-coding regions, and are commonly assigned to the nearest gene along the ...
    • A unified phylogeny-based nomenclature for histone variants 

      Talbert, Paul B.; Ahmad, Kami; Almouzni, Geneviève; Ausió, Juan; Berger, Frederic; Thompson, Eric M.; Bhalla, Prem L.; Bonner, William M.; Cande, W. Zacheus; Chadwick, Brian P.; Chan, Simon W. L.; Cross, George A. M.; Cui, Liwang; Dimitrov, Stefan I.; Doenecke, Detlef; Eirin-López, José M.; Gorovsky, Martin A.; Hake, Sandra B.; Hamkalo, Barbara A.; Holec, Sarah; Jacobsen, Steven E.; Kamieniarz, Kinga; Khochbin, Saadi; Ladurner, Andreas G.; Landsman, David; Latham, John A.; Loppin, Benjamin; Malik, Harmit S.; Marzluff, William F.; Pehrson, John R.; Postberg, Jan; Schneider, Robert; Singh, Mohan B.; Smith, M. M.; Torres-Padilla, Maria-Elena; Tremethick, David J.; Turner, Bryan M.; Waterborg, Jakob H.; Wollmann, Heike; Yelagandula, Ramesh; Zhu, Bing; Henikoff, Steven (Peer reviewed; Journal article, 2012-06-21)
      Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions for ...
    • The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution 

      Hausen, Harald; Döring, Clemens; Kumar, Suman; Tumu, Sharat Chandra; Kourtesis, Ioannis (Journal article; Peer reviewed, 2020)
      Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology. First ...
    • Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods 

      Lewis, Samuel H.; Ross, Laura; Bain, Stevie A.; Pahita, Eleni; Smith, Stephen A.; Cordaux, Richard; Miska, Eric A.; Lenhard, Boris; Jiggins, Francis M.; Sarkies, Peter (Journal article; Peer reviewed, 2020)
      Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters ...
    • Xenacoelomorpha's significance for understanding bilaterian evolution 

      Hejnol, Andreas; Pang, Kevin Scott (Journal article; Peer reviewed, 2016-08)
      The Xenacoelomorpha, with its phylogenetic position as sister group of the Nephrozoa (Protostomia + Deuterostomia), plays a key-role in understanding the evolution of bilaterian cell types and organ systems. Current studies ...