• Chromatin jets define the properties of cohesin-driven in vivo loop extrusion 

      Guo, Ya; Al-Jibury, Ediem; Garcia-Millan, Rosalba; Ntagiantas, Konstantinos; King, James W.D.; Nash, Alex J.; Galjart, Niels; Lenhard, Boris; Rueckert, Daniel; Fisher, Amanda G.; Pruessner, Gunnar; Merkenschlager, Matthias (Journal article; Peer reviewed, 2022)
      Complex genomes show intricate organization in three-dimensional (3D) nuclear space. Current models posit that cohesin extrudes loops to form self-interacting domains delimited by the DNA binding protein CTCF. Here, we ...
    • A deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks 

      Al-jibury, Ediem; King, James W. D.; Guo, Ya; Lenhard, Boris; Fisher, Amanda G.; Merkenschlager, Matthias; Rueckert, Daniel (Journal article; Peer reviewed, 2023)
      The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce genome-wide chromatin contact maps that provide rich data ...
    • Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin 

      Weiss, Felix D.; Calderon, Lesly; Wang, Yi-Fang; Georgieva, Radina; Guo, Ya; Cvetesic, Nevena; Kaur, Maninder; Dharmalingam, Gopuraja; Krantz, Ian D.; Lenhard, Boris; Fisher, Amanda G.; Merkenschlager, Matthias (Journal article; Peer reviewed, 2021)
      Cornelia de Lange Syndrome (CdLS) is a human developmental disorder caused by mutations that compromise the function of cohesin, a major regulator of 3D genome organization. Cognitive impairment is a universal and as yet ...