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dc.contributor.authorBramham, Clive R.en_US
dc.contributor.authorAlme, Maria N.en_US
dc.contributor.authorBittins, Margaretheen_US
dc.contributor.authorKuipers, Sjoukje D.en_US
dc.contributor.authorNair, Rajeevkumar R.en_US
dc.contributor.authorPai, Balagopalen_US
dc.contributor.authorPanja, Debabrataen_US
dc.contributor.authorSchubert, Manjaen_US
dc.contributor.authorSoule, Jonathanen_US
dc.contributor.authorTiron, Adrianen_US
dc.contributor.authorWibrand, Karinen_US
dc.PublishedExperimental Brain Research 200: 125-140en_US
dc.description.abstractThe immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. Here, we attempt to overview the Arc system spanning from transcriptional regulation of the Arc gene, to dendritic transport, metabolism, and translation of Arc mRNA, to post-translational modiWcation, localization, and degradation of Arc protein. Within this framework we discuss the function of Arc in regulation of actin cytoskeletal dynamics underlying consolidation of long-term potentiation (LTP) and regulation of AMPA-type glutamate receptor endocytosis underlying long-term depression (LTD) and homeostatic plasticity. Behaviorally, Arc has a key role in consolidation of explicit and implicit forms of memory, with recent work implicating Arc in adaptation to stress as well as maladaptive plasticity connected to drug addiction. Arc holds considerable promise as a “master regulator” of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated.en_US
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.subjectSynaptic plasticityeng
dc.subjectGene expressioneng
dc.subjectDrug addictioneng
dc.subjectRNA decayeng
dc.titleThe Arc of synaptic memoryen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2009. This article is published with open access at
dc.rights.holderThe Author(s) 2009
dc.subject.nsiVDP::Medical disciplines: 700eng

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