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dc.contributor.authorBrügger-Andersen, Trygveen_US
dc.contributor.authorBostad, Leifen_US
dc.contributor.authorSandnes, Dagny A.en_US
dc.contributor.authorLarsen, Alf Ingeen_US
dc.contributor.authorBonarjee, Vernon V. S.en_US
dc.contributor.authorBarvik, Ståleen_US
dc.contributor.authorMelberg, Toren_US
dc.contributor.authorNilsen, Dennis W. T.en_US
dc.PublishedThrombosis Journal 8:1en_US
dc.description.abstractBackground The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI). Methods The atherothrombotic samples were collected from a consecutive cohort consisting of 20 individuals admitted with STEMI to Stavanger University Hospital, Norway, from 2005-2006, presenting angiographically with an acute thrombotic occlusion of a coronary artery characterized by TIMI flow 0. The atherothrombotic plaques were obtained by aspiration thrombectomy during percutaneous coronary intervention within 12 hours from the onset of symptoms and prepared for IHC analysis. Results In the IHC analysis staining for PAPP-A occurred in the extracellular matrix of the plaques and no evidence of staining for PAPP-A was found in the thrombi. Conclusion Our results indicate that in vivo PAPP-A is strongly expressed in atherothrombotic plaques harvested from patients admitted with STEMI, as documented by IHC.en_US
dc.rightsAttribution CC BYeng
dc.titleThe activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communicationen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2010 Brügger-Andersen et al; licensee BioMed Central Ltd.
dc.rights.holderBrügger-Andersen et al.

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