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dc.contributor.authorFangberget, A.en_US
dc.contributor.authorNilsen, L. B.en_US
dc.contributor.authorHole, Knut Håkonen_US
dc.contributor.authorHolmen, M. M.en_US
dc.contributor.authorEngebraaten, O.en_US
dc.contributor.authorNaume, B.en_US
dc.contributor.authorSmith, H.-J.en_US
dc.contributor.authorOlsen, Dag R.en_US
dc.contributor.authorSeierstad, Thereseen_US
dc.date.accessioned2011-11-28T11:31:57Z
dc.date.available2011-11-28T11:31:57Z
dc.date.issued2011eng
dc.PublishedEuropean Radiology 21(6): 1188-1199en
dc.identifier.issn0938-7994
dc.identifier.urihttps://hdl.handle.net/1956/5237
dc.description.abstractObjective To explore the predictive value of MRI parameters and tumour characteristics before neoadjuvant chemotherapy (NAC) and to compare changes in tumour size and tumour apparent diffusion coefficient (ADC) during treatment, between patients who achieved pathological complete response (pCR) and those who did not. Methods Approval by the Regional Ethics Committee and written informed consent were obtained. Thirty-one patients with invasive breast carcinoma scheduled for NAC were enrolled (mean age, 50.7; range, 37–72). Study design included MRI before treatment (Tp0), after four cycles of NAC (Tp1) and before surgery (Tp2). Data in pCR versus non-pCR groups were compared and cut-off values for pCR prediction were evaluated. Results Before NAC, HER2 overexpression was the single significant predictor of pCR (p=0.006). At Tp1 ADC, tumour size and changes in tumour size were all significantly different in the pCR and non-pCR groups. Using 1.42×10−3 mm2/s as the cut-off value for ADC, pCR was predicted with sensitivity and specificity of 88% and 80%, respectively. Using a cut-off value of 83% for tumour volume reduction, sensitivity and specificity for pCR were 91% and 80%. Conclusion ADC, tumour size and tumour size reduction at Tp1 were strong independent predictors of pCR.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rights.urihttp://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0eng
dc.subjectNeoadjuvant chemotherapyeng
dc.subjectBreast cancereng
dc.titleNeoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imagingen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holder©The Author(s) 2011
dc.identifier.doihttps://doi.org/10.1007/s00330-010-2020-3
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762eng
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Radiology and diagnostic imaging: 763eng


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