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dc.contributor.authorHestvik, Elinen_US
dc.contributor.authorTylleskär, Thorkilden_US
dc.contributor.authorNdeezi, Graceen_US
dc.contributor.authorGrahnquist, Lenaen_US
dc.contributor.authorOlafsdottir, Eddaen_US
dc.contributor.authorTumwine, James K.en_US
dc.contributor.authorKaddu-Mulindwa, Deogratias H.en_US
dc.PublishedJournal of the International AIDS Society 2011, 14:34en
dc.description.abstractBackground: The aim of this survey was to determine the prevalence of and factors associated with Helicobacter pylori (H. pylori) colonization in HIV-infected, highly active antiretroviral therapy-naïve Ugandan children aged 0-12 years. Methods: In a hospital-based survey, 236 HIV-infected children were tested for H. pylori colonization using a faecal antigen test. A standardized interview with socio-demographic information and medical history was used to assess risk factors. A cluster of differentiation 4 (CD4) cell percentage was prevalent in most children. Results: The overall prevalence of H. pylori in the HIV-infected children was 22.5%. Age-specific prevalence was as follows: up to one year, 14.7%; 1-3 years, 30.9%; and 3-12 years, 20.7%. HIV-infected children who were more seriously affected by their disease (low CD4 cell percentage or WHO clinical stage II-IV) were less likely to be colonized with H. pylori. There was a trend for a lower prevalence of H. pylori in children who had taken antibiotics for the preceding two weeks (21.6%) than in those who had not taken antibiotics (35.7%). There was no statistically significant difference in prevalence by gender, housing, congested living, education of the female caretaker, drinking water or toilet facilities. Conclusions: HIV-infected, HAART-naïve Ugandan children had a lower prevalence of H. pylori colonization compared with apparently healthy Ugandan children (44.3%). Children with a low CD4 cell percentage and an advanced clinical stage of HIV had an even lower risk of H. pylori colonization. Treatment with antibiotics due to co-morbidity with infectious diseases is a possible explanation for the relatively low prevalence.en_US
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="" target="blank">Helicobacter pylori and faecal calprotectin in apparently healthy and HIV-infected Ugandan children</a>eng
dc.rightsAttribution CC BYeng
dc.titlePrevalence of Helicobacter pylori in HIV-infected, HAART-naïve Ugandan children: a hospital-based surveyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2011 Hestvik et al; licensee BioMed Central Ltd.
dc.subject.nsiVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801eng

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