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dc.contributor.authorEl-Salhy, Magdyen_US
dc.contributor.authorGundersen, Dorisen_US
dc.contributor.authorØstgaard, Hegeen_US
dc.contributor.authorLomholt-Beck, B.en_US
dc.contributor.authorHatlebakk, Jan Gunnaren_US
dc.contributor.authorHausken, Trygveen_US
dc.date.accessioned2012-04-16T09:53:32Z
dc.date.available2012-04-16T09:53:32Z
dc.date.issued2011-11-05eng
dc.PublishedDigestive Diseases and Sciences 57(4): 873-878en
dc.identifier.issn0163-2116
dc.identifier.urihttps://hdl.handle.net/1956/5749
dc.description.abstractBackground The gut hormones are important in regulating gastrointestinal motility. Disturbances in gastrointestinal motility have been reported in patients with irritable bowel syndrome (IBS). Reduced endocrine cell density, as revealed by chromogranin A, has been reported in the colon of IBS patients. Aims To investigate a possible abnormality in the colonic endocrine cells of IBS patients. Methods A total of 41 patients with IBS according to Rome Criteria III and 20 controls were included in the study. Biopsies from the right and left colon were obtained from both patients and controls during colonoscopy. The biopsies were immunostained for serotonin, peptide YY (PYY), pancreatic polypeptide (PP), entroglucagon, and somatostatin cells. Cell densities were quantified by computerized image analysis. Results Serotonin and PYY cell densities were reduced in the colon of IBS patients. PP, entroglucagon, and somatostatin- immunoreactive cells were too few to enable reliable quantification.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rights.urihttp://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0eng
dc.subjectColoneng
dc.subjectImmunohistochemistryeng
dc.titleLow Densities of Serotonin and Peptide YY Cells in the Colon of Patients with Irritable Bowel Syndromeen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright the Author(s) 2011
dc.identifier.doihttps://doi.org/10.1007/s10620-011-1948-8
dc.identifier.cristin918696
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773eng


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