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dc.contributor.authorHertel, Jens Kristofferen_US
dc.contributor.authorJohansson, Stefanen_US
dc.contributor.authorSonestedt, Emilyen_US
dc.contributor.authorJonsson, Annaen_US
dc.contributor.authorLie, Rolv Terjeen_US
dc.contributor.authorPlatou, Carl G. P.en_US
dc.contributor.authorNilsson, Peter M.en_US
dc.contributor.authorRukh, Gullen_US
dc.contributor.authorMidthjell, Kristianen_US
dc.contributor.authorHveem, Kristianen_US
dc.contributor.authorMelander, Olleen_US
dc.contributor.authorGroop, Leifen_US
dc.contributor.authorLyssenko, Valeriyaen_US
dc.contributor.authorMolven, Andersen_US
dc.contributor.authorOrho-Melander, Marjuen_US
dc.contributor.authorNjølstad, Pål Rasmusen_US
dc.date.accessioned2012-09-27T07:48:00Z
dc.date.available2012-09-27T07:48:00Z
dc.date.issued2011-05eng
dc.PublishedDiabetes 60: 1637–1644eng
dc.identifier.urihttps://hdl.handle.net/1956/6049
dc.descriptionThis article contains Supplementary Data online at <a href="http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db10-1340/-/DC1" target="blank">http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db10-1340/-/DC1.</a>eng
dc.description.abstractOBJECTIVE—FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span. RESEARCH DESIGN AND METHODS—Through regression models, we assessed the relationship between the FTO single nucleotide polymorphisms rs9939609, type 2 diabetes, and BMI across life span in subjects from the Norwegian population-based HUNT study using cross-sectional and longitudinal perspectives. For replication and meta-analysis, we used data from the Malmö Diet and Cancer (MDC) and Malmö Preventive Project (MPP) cohorts, comprising a total sample of 41,504 Scandinavians.RESULTS—The meta-analysis revealed a highly significant association for rs9939609 with both type 2 diabetes (OR 1.13; P = 4.5 3 1028) and the risk to develop incident type 2 diabetes (OR 1.16; P = 3.2 3 1028). The associations remained also after correction for BMI and other anthropometric measures. Furthermore, we confirmed the strong effect on BMI (0.28 kg/m2 per risk allele; P = 2.0 3 10226), with no heterogeneity between different age-groups. We found no differences in change of BMI over time according to rs9939609 risk alleles, neither overall (ΔBMI = 0.0[20.05, 0.05]) nor in any individual age stratum, indicating no further weight gain attributable to FTO genotype in adults. CONCLUSIONS—We have identified that a variant in FTO alters type 2 diabetes risk partly independent of its observed effect on BMI. The additional weight gain as a result of the FTO risk variant seems to occur before adulthood, and the BMI difference remains stable thereafter.en_US
dc.language.isoengeng
dc.publisherAmerican Diabetes Associationeng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/6050">Genetic Risk Factors for Type 2 Diabetes and Related Traits</a>eng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/eng
dc.titleFTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life: A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studiesen_US
dc.typeResearch report
dc.typePeer reviewed
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
dc.identifier.doihttps://doi.org/10.2337/db10-1340


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