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dc.contributor.authorErsland, Kari Mereteen_US
dc.contributor.authorChristoforou, Andreaen_US
dc.contributor.authorStansberg, Christineen_US
dc.contributor.authorEspeseth, Thomasen_US
dc.contributor.authorMattheisen, Manuelen_US
dc.contributor.authorMattingsdal, Mortenen_US
dc.contributor.authorHardarson, Gudmundur A.en_US
dc.contributor.authorHansen, Thomasen_US
dc.contributor.authorFernandes, Carla P. D.en_US
dc.contributor.authorGiddaluru, Sudheeren_US
dc.contributor.authorBreuer, Renéen_US
dc.contributor.authorStrohmaier, Janaen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorNöthen, Markus M.en_US
dc.contributor.authorRietschel, Marcellaen_US
dc.contributor.authorLundervold, Astri Johansenen_US
dc.contributor.authorWerge, Thomasen_US
dc.contributor.authorCichon, Svenen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorReinvang, Ivaren_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.contributor.authorLe Hellard, Stephanieen_US
dc.PublishedPLoS One (7)2: e31687eng
dc.description.abstractBackground: Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Recently, we reported on sets of regionally enriched genes in three different cortical areas (frontomedial, temporal and occipital cortices) of the adult rat brain. It has been suggested that genes preferentially, or specifically, expressed in one region or organ reflect functional specialisation. Employing a gene-based approach to the analysis, we used the regionally enriched cortical genes to mine a genome-wide association study (GWAS) of the Norwegian Cognitive NeuroGenetics (NCNG) sample of healthy adults for association to nine psychometric tests measures. In addition, we explored GWAS data sets for the serious psychiatric disorders schizophrenia (SCZ) (n = 3 samples) and bipolar affective disorder (BP) (n = 3 samples), to which cognitive impairment is linked. Principal Findings: At the single gene level, the temporal cortex enriched gene RAR-related orphan receptor B (RORB) showed the strongest overall association, namely to a test of verbal intelligence (Vocabulary, P = 7.7E-04). We also applied gene set enrichment analysis (GSEA) to test the candidate genes, as gene sets, for enrichment of association signal in the NCNG GWAS and in GWASs of BP and of SCZ. We found that genes differentially expressed in the temporal cortex showed a significant enrichment of association signal in a test measure of non-verbal intelligence (Reasoning) in the NCNG sample. Conclusion: Our gene-based approach suggests that RORB could be involved in verbal intelligence differences, while the genes enriched in the temporal cortex might be important to intellectual functions as measured by a test of reasoning in the healthy population. These findings warrant further replication in independent samples on cognitive traits.en_US
dc.relation.ispartof<a href="" target="blank">Identification and characterisation of regionally enriched cortex genes in the rat brain</a>eng
dc.rightsAttribution CC BYeng
dc.titleGene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disordersen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2012 Ersland et al.

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