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dc.contributor.authorHåvik, Bjarteen_US
dc.contributor.authorFernandes, Carla P. D.en_US
dc.contributor.authorChristoforou, Andreaen_US
dc.contributor.authorErsland, Kari Mereteen_US
dc.contributor.authorGiddaluru, Sudheeren_US
dc.contributor.authorCichon, Svenen_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.contributor.authorHellard, Stéphanie Leen_US
dc.contributor.authorJohansson, Stefanen_US
dc.contributor.authorBramham, Clive R.en_US
dc.contributor.authorHaavik, Janen_US
dc.date.accessioned2013-04-04T09:24:31Z
dc.date.available2013-04-04T09:24:31Z
dc.date.issued2012-04-23eng
dc.PublishedPLoS ONE 7(4): e35424eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/6478
dc.description.abstractDoublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of DCLK1 variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or through collaboration; three for BP, two for SCZ and one for ADHD. We also genotyped the DCLK1 region in additional samples of cases with SCZ, BP or ADHD and controls that had not been whole-genome typed. In total, 9895 subjects were analysed, including 5308 normal controls and 4,587 patients (1,125 with SCZ, 2,496 with BP and 966 with ADHD). Several DCLK1 variants were associated with disease phenotypes in the different samples. The main effect was observed for rs7989807 in intron 3, which was strongly associated with SCZ alone and even more so when cases with SCZ and ADHD were combined (P-value = 4×10−5 and 4×10−6, respectively). Associations were also observed with additional markers in intron 3 (combination of SCZ, ADHD and BP), intron 19 (SCZ+BP) and the 3′UTR (SCZ+BP). Our results suggest that genetic variants in DCLK1 are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility. Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity.en_US
dc.language.isoengeng
dc.publisherPublic Library of Scienceeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/eng
dc.titleDCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorderen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2012 Håvik et al.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0035424
dc.identifier.cristin945446


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