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dc.contributor.authorTalbert, Paul B.eng
dc.contributor.authorAhmad, Kamieng
dc.contributor.authorAlmouzni, Genevièveeng
dc.contributor.authorAusió, Juaneng
dc.contributor.authorBerger, Fredericeng
dc.contributor.authorThompson, Eric M.eng
dc.contributor.authorBhalla, Prem L.eng
dc.contributor.authorBonner, William M.eng
dc.contributor.authorCande, W. Zacheuseng
dc.contributor.authorChadwick, Brian P.eng
dc.contributor.authorChan, Simon W. L.eng
dc.contributor.authorCross, George A. M.eng
dc.contributor.authorCui, Liwangeng
dc.contributor.authorDimitrov, Stefan I.eng
dc.contributor.authorDoenecke, Detlefeng
dc.contributor.authorEirin-López, José M.eng
dc.contributor.authorGorovsky, Martin A.eng
dc.contributor.authorHake, Sandra B.eng
dc.contributor.authorHamkalo, Barbara A.eng
dc.contributor.authorHolec, Saraheng
dc.contributor.authorJacobsen, Steven E.eng
dc.contributor.authorKamieniarz, Kingaeng
dc.contributor.authorKhochbin, Saadieng
dc.contributor.authorLadurner, Andreas G.eng
dc.contributor.authorLandsman, Davideng
dc.contributor.authorLatham, John A.eng
dc.contributor.authorLoppin, Benjamineng
dc.contributor.authorMalik, Harmit S.eng
dc.contributor.authorMarzluff, William F.eng
dc.contributor.authorPehrson, John R.eng
dc.contributor.authorPostberg, Janeng
dc.contributor.authorSchneider, Roberteng
dc.contributor.authorSingh, Mohan B.eng
dc.contributor.authorSmith, M. M.eng
dc.contributor.authorTorres-Padilla, Maria-Elenaeng
dc.contributor.authorTremethick, David J.eng
dc.contributor.authorTurner, Bryan M.eng
dc.contributor.authorWaterborg, Jakob H.eng
dc.contributor.authorWollmann, Heikeeng
dc.contributor.authorYelagandula, Ramesheng
dc.contributor.authorZhu, Bingeng
dc.contributor.authorHenikoff, Steveneng
dc.PublishedEpigenetics & Chromatin 2012, 5:7eng
dc.description.abstractHistone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions for them has led to a variety of naming styles, multiple synonyms and misleading homographs that obscure variant relationships and complicate database searches. We propose here a unified nomenclature for variants of all five classes of histones that uses consistent but flexible naming conventions to produce names that are informative and readily searchable. The nomenclature builds on historical usage and incorporates phylogenetic relationships, which are strong predictors of structure and function. A key feature is the consistent use of punctuation to represent phylogenetic divergence, making explicit the relationships among variant subtypes that have previously been implicit or unclear. We recommend that by default new histone variants be named with organism-specific paralog-number suffixes that lack phylogenetic implication, while letter suffixes be reserved for structurally distinct clades of variants. For clarity and searchability, we encourage the use of descriptors that are separate from the phylogeny-based variant name to indicate developmental and other properties of variants that may be independent of structure.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.titleA unified phylogeny-based nomenclature for histone variantseng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.rights.holderCopyright 2012 Talbert et al.; licensee BioMed Central Ltd.
dc.source.journalEpigenetics & Chromatin

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