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dc.contributor.authorAndersen, Aase B.en_US
dc.contributor.authorRange, Nyagosya S.en_US
dc.contributor.authorChangalucha, Johnen_US
dc.contributor.authorPrayGod, Georgeen_US
dc.contributor.authorKidola, Jeremiahen_US
dc.contributor.authorGrewal, Harleen M. S.en_US
dc.contributor.authorFaurholt-Jepsen, Danielen_US
dc.contributor.authorKrarup, Henriken_US
dc.contributor.authorFriis, Henriken_US
dc.PublishedBMC Infectious Diseases 2012, 12:66eng
dc.description.abstractBackground: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported. Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area. Results: Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and 110 (52; 168) CD4 cells per μL after 5 months. Conclusions: The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.subjectPulmonary tuberculosiseng
dc.subjectCD4 cellseng
dc.subjectTB treatmenteng
dc.titleCD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without hiv co-infectionen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2012 Andersen et al; licensee BioMed Central Ltd.
dc.source.journalBMC Infectious Diseases

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