Browsing Department of Clinical Science by Title
Now showing items 2562-2567 of 2567
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The Zebrafish Larva as a Model System for Myeloid Malignancies
(Doctoral thesis, 2024-02-23)Myeloid kreft er ein ukontrollert deling av dei myeloide stamcellene som finst i beinmergen. Døme på myeloid kreft er akutt myeloid leukemi (AML) og myelodysplastisk syndrom. Desse kreftformane er vanlegast hjå eldre ... -
Zebrafish Larvae as a Model Organism to Study Biotransformation
(Master thesis, 2023-05-22)The zebrafish larva is an increasingly used model organism in many fields of research, including drug development. Due to traits like their small size, rapid development, and high degree of genetic similarity with humans, ... -
Zebrafish Larvae as a Model to Study Doxorubicin-Induced Cardiotoxicity
(Master thesis, 2020-06-30)Doxorubicin is one of the most versatile cytostatic drugs available and shows efficacy on most cancer forms. However, it also possesses the risk of cardiotoxicity that is hard to predict, can occur decades after treatment, ... -
α1-Antichymotrypsin Complex (SERPINA3) Is an Independent Predictor of All-Cause but Not Cardiovascular Mortality in Patients Hospitalized for Chest Pain of Suspected Coronary Origin
(Journal article; Peer reviewed, 2024)Introduction: SERPINA3 is an acute phase protein triggered by inflammation. It is upregulated after an acute myocardial infarction (AMI). Data on its long-term prognostic value in MI patients are scarce. We aimed to assess ... -
β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A
(Journal article; Peer reviewed, 2021)Aims Blockade of β-adrenoceptors reduces sympathetic nervous system activity and improves survival in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, any improvement in ... -
β2-adrenergic receptor expression in patients receiving bevacizumab therapy for metastatic melanoma
(Journal article; Peer reviewed, 2023)Background Vascular endothelial growth factor (VEGF) was initially known as vascular permeability factor and identified as a driver of tumour angiogenesis. Recently, its role in supporting an immunosuppressive tumour ...