Blar i Department of Clinical Science på tittel
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The immunological dilemma: Cellular innate and adaptive immune response versus human acute myeloid leukemia
(Peer reviewed; Journal article, 2007)It is generally accepted that acute myelogenous leukemia (AML) patients are immunocompromized. On the other hand, antileukemic immune reactivity is important for the improved survival of AML patients treated with allogeneic ... -
Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses
(Peer reviewed; Journal article, 2018-09-22)Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ... -
Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line
(Journal article; Peer reviewed, 2019)Changes in the immune system induced by tyrosine kinase inhibitors (TKI) have been shown to positively correlate with therapy responses in chronic myeloid leukemia (CML). However, only a few longitudinal studies exist and ... -
The immunology of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; what can the tonsils reveal. A literature review.
(Peer reviewed; Journal article, 2020)Objectives: Tonsillectomy (TE) or adenotonsillectomy (ATE) may have a beneficial effect on the clinical course in children with the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. ... -
Immunomodulation induced by stem cell mobilization and harvesting in healthy donors: Increased systemic osteopontin levels after treatment with granulocyte colony-stimulating factor
(Peer reviewed; Journal article, 2016-07-19)Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe ... -
Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells
(Peer reviewed; Journal article, 2018-01-29)Serotonin is a monoamine neurotransmitter that signals through a wide array of receptors (5-HT1–7) many of which are also involved in immune processes. Dendritic cells (DCs) are crucial players in immune defense by bridging ... -
Immunomodulatory Drugs Alter the Metabolism and the Extracellular Release of Soluble Mediators by Normal Monocytes
(Journal article; Peer reviewed, 2020)Immunomodulatory drugs (IMiDs) are used in the treatment of hematological malignancies, especially multiple myeloma. IMiDs have direct anticancer effects but also indirect effects via cancer-supporting stromal cells. ... -
Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome
(Peer reviewed; Journal article, 2012-10-14)Background: A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting ... -
Immunoregulatory networks in healthy adult allogeneic stem cell donors : Studies of peripheral hematopoietic stem cell donors and their recipients
(Doctoral thesis, 2020-10-28)Final outcome after allogeneic peripheral blood stem cell transplantation (PBSCT) is influenced by the high degrees of variation in disease and comorbidities among recipients, as well as the pre-and post-transplant handling ... -
Impact of a Mobile Application for Tracking Nausea and Vomiting During Pregnancy (NVP) on NVP Symptoms, Quality of Life, and Decisional Conflict Regarding NVP Treatments: MinSafeStart Randomized Controlled Trial
(Journal article; Peer reviewed, 2022)Background: Pregnant women are active users of mobile apps for health purposes. These apps may improve self-management of health-related conditions. Up to 70% of pregnant women experience nausea and vomiting (NVP). Even ... -
Impact of a surgical safety checklist on safety culture, morbidity, and mortality. A stepped-wedge cluster randomised controlled trial
(Doctoral thesis, 2014-08-26)Introduction: The incidence of in-hospital adverse events is estimated to occur in approximately 1 out of 10 patients. Events happening during surgical procedures contribute up to 60%, and of these, more than half are ... -
Impact of aortic stiffness on myocardial ischaemia in non-obstructive coronary artery disease
(Peer reviewed; Journal article, 2019)Objective: High aortic stiffness may reduce myocardial perfusion pressure and contribute to development of myocardial ischaemia. Whether high aortic stiffness is associated with myocardial ischaemia in patients with stable ... -
Impact of aortic valve stenosis on myocardial deformation in different left ventricular levels: A three-dimensional speckle tracking echocardiography study
(Journal article; Peer reviewed, 2023)Background: Global systolic left ventricular (LV) myocardial function progressively declines as degenerative aortic valve stenosis (AS) progresses. Whether this results in uniformly distributed deformation changes from ... -
Impact of arterio–ventricular interaction on first-phase ejection fraction in aortic stenosis
(Peer reviewed; Journal article, 2020)Aims: First-phase ejection fraction (EF1), the EF at the time to peak aortic jet velocity, has been proposed as a novel marker of peak systolic function in aortic stenosis (AS). This study aimed to explore the association ... -
Impact of different preanalytical conditions on results of lupus anticoagulant tests
(Peer reviewed; Journal article, 2019)Introduction: The currently recommended preanalytical conditions for lupus anticoagulant (LA) analysis require analyzing samples in fresh or freshly frozen platelet‐poor plasma. The aim of this study was to evaluate whether ... -
Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction
(Peer reviewed; Journal article, 2018-04-30)HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition ... -
Impact of hormonal biomarkers on response to hormonal therapy in advanced and recurrent endometrial cancer
(Journal article; Peer reviewed, 2021)Background Approximately 20% of women with endometrial cancer have advanced-stage disease or suffer from a recurrence. For these women, prognosis is poor, and palliative treatment options include hormonal therapy and ... -
Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3
(Peer reviewed; Journal article, 2012-01-13)Background and Aims: Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome ... -
Impact of Inititing Biologics in Patients With Severe Asthma on Long-term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry
(Journal article; Peer reviewed, 2023)Background Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective To examine ... -
Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients
(Journal article; Peer reviewed, 2021)Background Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal ...