Blar i Department of Clinical Science på tittel

Viser treff 147-166 av 2313

    • Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer 

      Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn (Peer reviewed; Journal article, 2010-06-21)
      Background The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and ...

    • Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate 

      Gansmo, Liv Beathe; Vatten, Lars Johan; Romundstad, Pål Richard; Hveem, Kristian; Ryan, Bríd M.; Harris, Curtis C.; Knappskog, Stian; Lønning, Per Eystein (Peer reviewed; Journal article, 2016-04-12)
      The MDM2 promoter region contains several polymorphisms, some of which have been associated with MDM2 expression, cancer risk and age at cancer onset. del1518 (rs3730485) is an indel polymorphism residing in the MDM2 ...

    • The associations between weight-related anthropometrics during childhood and lung function in late childhood: a retrospective cohort study 

      Byberg, Kristine Kjer; Mikalsen, Ingvild Bruun; Eide, Geir Egil; Forman, Michele R.; Júlíusson, Pétur Benedikt; Øymar, Knut (Peer reviewed; Journal article, 2018-01-19)
      Background: An association between body weight in childhood and subsequent lung function and asthma has been suggested, but few longitudinal studies exist. Our aim was to explore whether weight-related anthropometric ...

    • Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine; Trøseid, Marius; Midttun, Øivind; Ueland, Per Magne; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Kummen, Martin; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background and aims Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio ...

    • Asthma, allergic rhinitis and atopic dermatitis in association with home environment - The RHINE study 

      Wang, Juan; Janson, Christer; Malinovschi, Andrei; Holm, Mathias; Franklin, Karl A.; Modig, Lars; Johannessen, Ane; Schlünssen, Vivi; Gislason, Thorarinn; Jögi, Nils Oskar; Norbäck, Dan (Journal article; Peer reviewed, 2022)
      We studied home environment exposures in relation to asthma, allergic rhinitis and atopic dermatitis among offspring of participants (parents) in the Respiratory Health in Northern Europe (RHINE) study (age ≤ 30 y). Totally ...

    • Asthma, atopy and lung function at 11 years of age after bronchiolitis in infancy 

      Mikalsen, Ingvild Bruun (Doctoral thesis, 2014-06-13)
      Background: Bronchiolitis is a frequently occurring respiratory disorder in young children, and also an established risk factor for subsequent recurrent wheeze and asthma. The association between bronchiolitis and later ...

    • Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: impact of virus and sex 

      Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Dalen, Ingvild; Halvorsen, Thomas; Mikalsen, Ingvild Bruun (Journal article; Peer reviewed, 2022)
      Background: Hospitalisation for bronchiolitis is a risk factor for asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of asthma ...

    • Asthma, atopy, and lung function in young adults after hospitalization for bronchiolitis in infancy 

      Sørensen, Karen Galta (Doctoral thesis, 2023-10-06)
      Bakgrunn: Bronkiolitt er en viral nedre luftveisinfeksjon som ofte rammer spedbarn. Respiratorisk syncytialt virus er det vanligste viruset ved bronkiolitt, etterfulgt av rhinovirus. Bronkiolitt er assosiert med økt risiko ...

    • ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma 

      Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Halle, Mari Kyllesø; Berg, Anna; Werner, Henrica Maria Johanna; Ræder, Maria B.; Kusonmano, Kanthida; Zou, June; Øyan, Anne Margrete; Stefansson, Ingunn; Trovik, Jone; Kalland, Karl-Henning; Chen, Hong-Wu; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2015)
      We have explored the potential for clinical implementation of ATAD2 as a biomarker for aggressive endometrial cancer by investigating to what extent immunohistochemical (IHC) staining for ATAD2 is feasible, reflects clinical ...

    • Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders 

      Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Peer reviewed, 2020)
      Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade ...

    • Atrial Dysfunction in Significant Atrial Functional Mitral Regurgitation: Phenotypes and Prognostic Implications 

      Cramariuc, Dana; Alfraidi, Hassan; Nagata, Yasufumi; Levine, Robert A.; Van Kampen, Antonia; Andrews, Carl; Hung, Judy (Journal article; Peer reviewed, 2023)
      Background: Atrial functional mitral regurgitation (AFMR) is associated with increased morbidity and mortality. Left atrial (LA) size and function in AFMR are poorly characterized. We aimed to assess LA function by reservoir ...

    • Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study 

      Kuwelker, Kanika; Zhou, Fan; Blomberg, Bjørn; Jalloh, Sarah Larteley Lartey; Brokstad, Karl Albert; Trieu, Mai Chi; Bansal, Amit; Madsen, Anders; Krammer, Florian; Mohn, Kristin Greve-Isdahl; Tøndel, Camilla; Linchausen, Dagrunn Waag; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2021)
      Background Households studies reflect the natural spread of SARS-CoV-2 in immunologically naive populations with limited preventive measures to control transmission. We hypothesise that seropositivity provides more ...

    • Attempted synthesis of a 2,3,6-trisubstituted 5-pyranone 

      Khalil Kadir, Hawjin (Master thesis, 2011-06-14)
      Carbohydrate analogues are of great interest for the development of new pharmaceutical products. These compounds are attached to the macromolecule via glycosidic linkages, and then influence directly the overall biological ...

    • Attempted synthesis of a 3-pyranone from 3,3,4,4-tetraethoxybut-1-yne 

      Nilsen, Elisabeth Nikoline (Master thesis, 2010-05-19)
      The starting material for this project was the highly functionalised compound 3,3,4,4-tetratethoxybut-1-yne (TEB). One of the compounds that can be synthesised from TEB is 1,1-diethoxy-3-(1,3-dithian-2-yl)propan-2-ol ...

    • Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder 

      Gudmundsson, Ólafur Ó.; Walters, Gudmundur Bragi; Ingason, Andrés; Johansson, Stefan; Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Gustafsson, Omar; Nawaz, Muhammad Sulaman; Jónsson, Gudbjörn F.; Jónsson, Lina; Knappskog, Per; Ingvarsdóttir, Ester; Davidsdóttir, Katrin; Djurovic, Srdjan; Knudsen, Gun Peggy Strømstad; Askeland, Ragna Bugge; Haraldsdóttir, Gyda S.; Baldursson, Gísli; Magnússon, Páll; Sigurdsson, Engilbert; Gudbjartsson, Daníel Fannar; Stéfansson, Hreinn; Andreassen, Ole Andreas; Haavik, Jan; Reichborn-Kjennerud, Ted; Stefánsson, Kári (Peer reviewed; Journal article, 2019-10-17)
      Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as ...

    • Attenuated Notch signaling in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018-03-28)
      The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ...

    • Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health 

      Johannessen, Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Kaale, Anett; Wirgenes, Katrine V.; Malt, Eva; Djurovic, Srdjan; Rietschel, Marcella; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)
      Clinical relevance of genetic testing is increasing in autism spectrum disorder (ASD). Information about genetic risk may contribute to improved diagnostics, treatment and family planning, but may also be perceived as a ...

    • Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts 

      Osterlund, Emerik; Ristimäki, Ari; Mäkinen, Markus J.; Kytölä, Soili; Kononen, Juha; Pfeiffer, Per; Soveri, Leena-Maija; Keinänen, Mauri; Sorbye, Halfdan; Nunes, Luís; Salminen, Tapio; Nieminen, Lasse; Uutela, Aki; Halonen, Päivi; Ålgars, Annika; Sundström, Jari; Kallio, Raija; Ristamäki, Raija; Lamminmäki, Annamarja; Stedt, Hanna; Heervä, Eetu; Kuopio, Teijo; Sjöblom, Tobias; Isoniemi, Helena; Glimelius, Bengt; Osterlund, Pia (Journal article; Peer reviewed, 2023)
      BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, ...

    • Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years 

      Trieu, Mai Chi; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Sridhar, Saranya; Mjaaland, Siri; Cox, Rebecca Jane (Peer reviewed; Journal article, 2018-08-14)
      Annual seasonal influenza vaccination is recommended for high-risk populations and often occupational groups such as healthcare workers (HCWs). Repeated annual vaccination has been reported to either have no impact or ...

    • Autoantibodies against type I IFNs in patients with life-threatening COVID-19 

      Bastard, Paul; Rosen, Lindsey B.; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jérémie; Béziat, Vivien; Manry, Jérémy; Shaw, Elana; Haljasmägi, Liis; Peterson, Pärt; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; de Jesus, Adriana Almeida; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Le Pen, Jeremie; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; Spaan, András N; Delmonte, Ottavia M.; Abers, Michael S.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; Lifton, Richard P.; Vasse, Marc; Smadja, David M.; Migaud, Mélanie; Hadjadj, Jérome; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; van de Beek, Diederik; Roussel, Lucie; Vinh, Donald C.; Tangye, Stuart G.; Haerynck, Filomeen; Dalmau, David; Martinez-Picado, Javier; Brodin, Petter; Nussenzweig, Michel C.; Boisson-Dupuis, Stéphanie; Rodríguez-Gallego, Carlos; Vogt, Guillaume; Mogensen, Trine H.; Oler, Andrew J.; Gu, Jingwen; Burbelo, Peter D.; Cohen, Jeffrey I.; Biondi, Andrea; Bettini, Laura Rachele; D'Angio, Mariella; Bonfanti, Paolo; Rossignol, Patrick; Mayaux, Julien; Rieux-Laucat, Frédéric; Husebye, Eystein Sverre; Fusco, Francesca; Ursini, Matilde Valeria; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Castagnoli, Riccardo; Montagna, Daniela; Licari, Amelia; Marseglia, Gian Luigi; Duval, Xavier; Ghosn, Jade; Tsang, John S.; Goldbach-Mansky, Raphaela; Kisand, Kai; Lionakis, Michail; Puel, Anne; Zhang, Shen-Ying; Holland, Steven M.; Gorochov, Guy; Jouanguy, Emmanuelle; Rice, Charles M.; Cobat, Aurelie; Notarangelo, Luigi D.; Abel, Laurent; Su, Helen C.; Casanova, Jean-Laurent (Journal article; Peer reviewed, 2020)
      Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease ...