Blar i Department of Clinical Science på tittel
Viser treff 1965-1984 av 2567
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Primary Hyperparathyroidism Influences the Expression of Inflammatory and Metabolic Genes in Adipose Tissue
(Peer reviewed; Journal article, 2011-06-17)Background: Primary hyperparathyroidism (PHPT) is characterised by increased production of parathyroid hormone (PTH) resulting in elevated serum calcium levels. The influence on bone metabolism with altered bone resorption ... -
Primary ovarian insufficiency in women with Addison's disease
(Journal article; Peer reviewed, 2021)Context: Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison’s disease (AAD) than in the general population, but their clinical ... -
Primary sclerosing cholangitis: Surrogate markers of natural history, disease severity, and prognosis
(Doctoral thesis, 2023-12-01)Sammendrag Bakgrunn: Primær skleroserende kolangitt (PSC) er en immunrelatert leversykdom av ukjent årsak som karakteriseres av kolestase, inflammasjon og strikturer i galletreet og vanligvis utvikler seg til generell ... -
Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins
(Journal article; Peer reviewed, 2023)High-grade serous ovarian carcinoma (HGSOC) is the most common and deadliest ovarian cancer subtype. Despite advances in treatment, the overall prognosis remains poor. Regardless of efforts to develop biomarkers to predict ... -
Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study
(Peer reviewed; Journal article, 2015-03)n several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways. ... -
Problemresepter i sykehusapotek - forekomst, oppfølging og dokumentasjon av potensielt kliniske problemer.
(Master thesis, 2020-06-30)Apotekfarmasøyter har som nøkkeloppgaver å sikre riktig og trygg legemiddelbruk hos befolkningen, og de utgjør ofte et av de siste leddene i kontroll og kvalitetssikring av legers forskrivninger, før legemidlene når ... -
Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin
(Journal article; Peer reviewed, 2023)Background: Extracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type ... -
Produksjon av EPA- og DHA-konsentrat fra frysetørket silderogn og sildemelke ved hjelp av ureakompleksering
(Master thesis, 2012-08-29)Herring roe and milt are high in omega-3 fatty acids that are proven to have various health benefits. The effects are best documented for cardiovascular disease, as well as inflammatory disorders such as arthritis. The ... -
Prognosis in asymptomatic patients with discordantly graded aortic valve stenosis based on pressure recovery adjusted valve area
(Journal article; Peer reviewed, 2022)Objective: We hypothesised that patients with asymptomatic aortic stenosis (AS) who remain with discordantly graded aortic valve stenosis (DGAS) after adjustment for pressure recovery in the aortic root represents a subgroup ... -
Prognostic factors, treatment approach and clinical outcomes from glioblastoma: a population-based observational cohort study from Western Norway
(Doctoral thesis, 2024-12-06)Bakgrunn: Glioblastom er den vanligste og mest aggressive primære hjernesvulst hos voksne, og prognosen er svært alvorlig med median overlevelse på omtrent 15 måneder tross standard behandling med radiokjemoterapi. I klinisk ... -
Prognostic impact of vitamin B6 metabolism in lung cancer
(Peer reviewed; Journal article, 2012-08-30)Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin ... -
Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
(Peer reviewed; Journal article, 2016-08)Current clinical algorithms are unable to precisely predict which colorectal cancer patients would benefit from adjuvant chemotherapy, and there is a need for novel biomarkers to improve the selection of patients. The ... -
Prognostic utility of vitamin D in acute coronary syndrome patients in coastal Norway
(Peer reviewed; Journal article, 2015)BACKGROUND: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist. OBJECTIVES: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients ... -
Prognostic value of baseline functional status measures and geriatric screening in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy – The randomized NORDIC9-study
(Journal article; Peer reviewed, 2023)Introduction Appropriate patient selection based on functional status is crucial when considering older adults for palliative chemotherapy. This pre-planned analysis of the randomized NORDIC9-study explored the prognostic ... -
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy
(Peer reviewed; Journal article, 2012-01-25)Background: Today’s clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced ... -
The prognostic value of pre-treatment circulating biomarkers of systemic inflammation (CRP, dNLR, YKL-40, and IL-6) in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—The Randomized NORDIC9-Study
(Journal article; Peer reviewed, 2022)Appropriate patient selection for palliative chemotherapy is crucial in patients with metastatic colorectal cancer (mCRC). We investigated the prognostic value of C-reactive protein (CRP), derived neutrophil-to-lymphocyte ... -
Prognostic value of the diversity of nuclear chromatin compartments in gynaecological carcinomas
(Journal article; Peer reviewed, 2020)Statistical texture analysis of cancer cell nuclei stained for DNA has recently been used to develop a pan-cancer prognostic marker of chromatin heterogeneity. In this study, we instead analysed chromatin organisation by ... -
The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of the patients who receive the most intensive treatment develop chemoresistant leukemia relapse. Although the leukemogenic events leading ...