Blar i Department of Clinical Science på tittel

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    • Detailed stratified GWAS analysis for severe COVID-19 in four European populations 

      Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Müller, Fredrik; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Dudman, Susanne Gjeruldsen; Folseraas, Trine; Skogen, Vegard; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Rühlemann, Malte C.; Arora, Jatin; Özer, Onur; Wacker, Eike Matthias; Wienbrandt, Lars; Ortiz, Aron Blandino; de Salazar, Adolfo; Chercoles, Adolfo Garrido; Palom, Adriana; Ruiz, Agustin; Garzia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Mayer, Alena; Bandera, Alessandra; Franke, Andre (Journal article; Peer reviewed, 2022)
      Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ...

    • Detection of a broad range of Leishmania species and determination of parasite load of infected mouse by real-time PCR targeting the arginine permease gene AAP3 

      Tellevik, Marit Gjerde; Müller, Karl Erik; Rebbestad, Karen; Nerland, Audun Helge (Peer reviewed; Journal article, 2014-09)
      Leishmaniasis is one of the world's most neglected infectious diseases, affecting around 12 million people and more than 350 million at risk of infection. The clinical picture varies from self-healing cutaneous lesions to ...

    • Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations 

      Bergland, Ola Undrum; Halvorsen, Lene Vernås; Søraas, Camilla Lund; Hjørnholm, Ulla; Kjær, Vibeke Norheim; Rognstad, Stine; Brobak, Karl Marius; Aune, Arleen; Olsen, Eirik; Fauchald, Ylva; Heimark, Sondre; Thorstensen, Christian W; Liestøl, Knut; Solbu, Marit Dahl; Gerdts, Eva; Mo, Rune; Rostrup, Morten; Kjeldsen, Sverre; Høieggen, Aud; Opdal, Mimi Stokke; Fadl Elmula, Fadl Elmula M. (Journal article; Peer reviewed, 2021)
      Nonadherence to drugs is a challenge in hypertension treatment. We aimed to assess the prevalence of nonadherence by serum drug concentrations compared with 2 indirect methods and relate to the prescribed drug regimens in ...

    • Detection of remaining Plasmodium DNA and gametocytes during follow up after curative malaria treatment among returned travellers in Norway 

      Haanshuus, Christel Gill; Mørch, Kristine (Journal article; Peer reviewed, 2020)
      Background PCR can be positive weeks after effective malaria treatment, potentially leading to over diagnose of recrudescence and re-infections. The DNA detected by PCR post-treatment might stem from residuals of destroyed ...

    • Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III 

      Nerpin, Elisabet; Olivieri, Mario; Gislason, Thorainn; Olin, Anna C.; Nielsen, Rune; Johannessen, Ane; Ferreira, Diogenes S.; Marcon, Alessandro; Cazzoletti, Lucia; Accordini, Simone; Pin, Isabelle; Corsico, Angelo; Demoly, Pascal; Weyler, Joost; Nowak, Dennis; Jõgi, Rain; Forsberg, Bertil; Zock, Jan P.; Sigsgaard, Torben; Heinric, Joachim; Bono, Roberto; Leynaert, Bénédicte; Jarvis, Deborah; Janson, Christer; Malinovschi, Anderi (Peer reviewed; Journal article, 2019)
      Introduction: The fractional exhaled nitric oxide (FENO ) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors ...

    • Determinants of interindividual variation in exercise-induced cardiac troponin I levels 

      Bjørkavoll-Bergseth, Magnus; Erevik, Christine Bjørkvik; Kleiven, Øyunn; Eijsvogels, Thijs M. H.; Skadberg, Øyvind; Frøysa, Vidar; Wiktorski, Tomasz; Auestad, Bjørn; Edvardsen, Thor; Aakre, Kristin Moberg; Ørn, Stein (Journal article; Peer reviewed, 2021)
      Background: Postexercise cardiac troponin levels show considerable interindividual variations. This study aimed to identify the major determinants of this postexercise variation in cardiac troponin I (cTnI) following 3 ...

    • Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes 

      Goodrich, Julia K.; Singer-Berk, Moriel; Son, Rachel; Sveden, Abigail; Wood, Jordan; England, Eleina; Cole, Joanne B.; Weisburd, Ben; Watts, Nick; Caulkins, Lizz; Dornbos, Peter; Koesterer, Ryan; Zappala, Zachary; Zhang, Haichen; Maloney, Kristin A.; Dahl, Andy; Aguilar-Salinas, Carlos A.; Atzmon, Gil; Barajas-Olmos, Francisco; Barzilai, Nir; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L.; Bottinger, Erwin; Bowden, Donald W.; Centeno-Cruz, Federico; Chambers, John C.; Chami, Nathalie; Chan, Edmund; Chan, Juliana; Cheng, Ching-Yu; Cho, Yoon Shin; Contreras-Cubas, Cecilia; Córdova, Emilio; Correa, Adolfo; DeFronzo, Ralph A.; Duggirala, Ravindranath; Dupuis, Josée; Garay-Sevilla, Ma Eugenia; García-Ortiz, Humberto; Gieger, Christian; Glaser, Benjamin; González-Villalpando, Clicerio; Gonzalez, Ma Elena; Grarup, Niels; Groop, L; Gross, Myron; Haiman, Christopher A.; Han, Sohee; Hanis, Craig L.; Hansen, Torben; Heard-Costa, Nancy L.; Henderson, Brian E.; Hernandez, Juan Manuel Malacara; Hwang, Mi Yeong; Islas-Andrade, Sergio; Jørgensen, Marit E.; Kang, Hyun Min; Kim, Bong-Jo; Kim, Young Jin; Koistinen, Heikki A.; Kooner, Jaspal Singh; Kuusisto, Johanna; Kwak, Soo-Heon; Laakso, Markku; Lange, Leslie; Lee, Jong-Young; Lee, Juyoung; Lehman, Donna M.; Linneberg, Allan; Liu, Jianjun; Loos, Ruth J. F.; Lyssenko, Valeriya; Ma, Ronald C. W.; Martínez-Hernández, Angélica; Meigs, James B.; Meitinger, Thomas; Mendoza-Caamal, Elvia; Mohlke, Karen L.; Morris, AD; Morrison, Alanna C.; Ng, Maggie C. Y.; Nilsson, Peter M.; O’Donnell, Christopher J.; Orozco, Lorena; Palmer, Colin N. A.; Park, Kyong Soo; Post, W; Pedersen, Oluf; Preuss, Michael; Psaty, Bruce M.; Reiner, Alexander P.; Revilla-Monsalve, Cristina; Rich, Stephen S.; Rotter, Jerome I.; Saleheen, Danish; Schurmann, Claudia; Sim, Xueling; Sladek, Rob; Small, Kerrin S.; So, Wing Yee; Spector, Timothy D.; Strauch, Konstantin; Strom, Tim M.; Tai, E. Shyong; Tam, Claudia H. T.; Teo, Yik Ying; Thameem, Farook; Tomlinson, Brian; Tracy, Russell P.; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Tusié-Luna, Teresa; van Dam, Rob M.; Vasan, Ramachandran S.; Wilson, James G.; Witte, Daniel R.; Wong, Tien-Yin; Burtt, Noël P.; Zaitlen, Noah; McCarthy, Mark I.; Boehnke, Michael; Pollin, Toni I.; Flannick, Jason; Mercader, Josep M.; O’Donnell-Luria, Anne; Baxter, Samantha; Florez, Jose C.; MacArthur, Daniel G.; Udler, MS (Journal article; Peer reviewed, 2021)
      Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. ...

    • Determination of conformations adopted by CXCR4 and CCR5 at the cell surface 

      Dyrhaug, Sunniva Yngvil (Master thesis, 2010-05-20)
      The chemokines and their receptors constitute many important physiological functions in the human body. The chemokine receptors belong to the family of G-protein coupled receptors, characterized by 7 α-helices penetrating ...

    • Determination of lower cut-off levels of adalimumab associated with biochemical remission in Crohn's disease 

      Carlsen, Arne; Omdal, Roald; Karlsen, Lars Normann; Kvaløy, Jan Terje; Aabakken, Lars; Steinsbø, Øyvind; Bolstad, Nils; Warren, David; Lundin, Knut Erik Aslaksen; Grimstad, Tore (Peer reviewed; Journal article, 2020)
      Background and Aim: Adalimumab is administered and dosed using a standardized treatment regimen. Although therapeutic drug monitoring (TDM) may help optimize treatment efficacy, the lower cut‐off concentration of adalimumab ...

    • Developing a core outcome set for hospital deprescribing trials for older people under the care of a geriatrician 

      Martin-Kerry, Jacqueline; Taylor, Jo; Scott, Sion; Patel, Martyn; Wright, David John; Clark, Allan; Turner, David; Alldred, David Phillip; Murphy, Katherine; Keevil, Victoria; Witham, Miles D.; Kellar, Ian; Bhattacharya, Debi (Journal article; Peer reviewed, 2022)
      Background Half of older people are prescribed unnecessary/inappropriate medications that are not routinely deprescribed in hospital hence there is a need for deprescribing trials. We aimed to develop a Core Outcome Set ...

    • Developing a flow cytometric method to characterize human T cell responses against the enteric protozoan parasite Giardia lamblia 

      Saghaug, Christina Skår (Master thesis, 2014-06-03)
      Giardia lamblia is an enteric protozoan parasite, which causes infection in humans worldwide. The impact of the infection varies from asymptomatic carriers to severe disease such as malabsorption syndrome. Evidence for ...

    • Development and external validation of prognostic models to predict sudden and pump-failure death in patients with HFrEF from PARADIGM-HF and ATMOSPHERE 

      Shen, Li; Claggett, Brian; Jhund, Pardeep S.; Abraham, William T.; Desai, Akshay S.; Dickstein, Kenneth; Gong, Jianjian; Køber, Lars; Lefkowitz, Martin; Rouleau, Jean L.; Shi, Victor; Swedberg, Karl; Zile, Michael R.; Solomon, Scott D.; McMurray, John J.V. (Journal article; Peer reviewed, 2021)
      Background: Sudden death (SD) and pump failure death (PFD) are the two leading causes of death in patients with heart failure and reduced ejection fraction (HFrEF). Objective: Identifying patients at higher risk for ...

    • Development of a bioluminescent nitroreductase probe for preclinical imaging 

      Vorobyeva, Anzhelika G.; Stanton, Michael; Godinat, Aurélien; Lund, Kjetil B.; Karateev, Grigory G.; Francis, Kevin P.; Allen, Elizabeth; Gelovani, Juri G.; McCormack, Emmet; Tangney, Mark; Dubikovskaya, Elena A. (Peer reviewed; Journal article, 2015-06-25)
      Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In ...

    • Development of a Disease-Specific Quality of Life Questionnaire in Addison’s Disease 

      Løvås, Kristian; Curran, Suzanne; Øksnes, Marianne; Husebye, Eystein Sverre; Huppert, Felicia A.; Chatterjee, V. Krishna K. (Peer reviewed; Journal article, 2010-02)
      Context: Patients with Addison’s disease reproducibly self-report impairment in specific dimensions of general well-being questionnaires, suggesting particular deficiencies in health-related quality-of-life (HRQoL). ...

    • Development of a Framework and the Content for a Psychoeducational Internet-Delivered Intervention for Women after Treatment for Gynecological Cancer 

      Sekse, Ragnhild Johanne Tveit; Nordgreen, Tine; Flobak, Eivind; Lystrup, Morten; Braathen, Espen; Werner, Henrica Maria Johanna (Journal article; Peer reviewed, 2021)
      The number of women treated for gynecological cancer is increasing. At the same time, the duration of in-patient hospitalization has decreased, and follow-up with its primary focus on early recognition of recurrence does ...

    • Development of a novel, high-affinity ssDNA trypsin inhibitor 

      Malicki, Stanislaw; Ksiazek, Miroslaw; Majewski, Pawel; Pecak, Aleksandra; Mydel, Piotr Mateusz; Grudnik, Przemyslaw; Dubin, Grzegorz (Peer reviewed; Journal article, 2019)
      Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we ...

    • Development of functional gastrointestinal disorders after Giardia lamblia infection 

      Hanevik, Kurt; Dizdar, Vernesa; Langeland, Nina; Hausken, Trygve (Peer reviewed; Journal article, 2009-04-21)
      Background: Functional gastrointestinal disorders (FGID) may occur following acute gastroenteritis. This long-term complication has previously not been described after infection with the non-invasive protozoan Giardia ...

    • Development of liposomal nanoencapsulation of lumefantrine with phosphatidylcholine/Tweens system 

      Fire, Berhane Zeresenay (Master thesis, 2021-05-20)

    • Development of lung diffusion to adulthood following extremely preterm birth 

      Satrell, Emma Elsa Carolina; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Hufthammer, Karl Ove; Thorsen, Einar; Halvorsen, Thomas; Vollsæter, Maria (Journal article; Peer reviewed, 2022)
      Background: Gas exchange in extremely preterm (EP) infants must take place in fetal lungs. Childhood lung diffusing capacity of the lung for carbon monoxide (DLCO) is reduced; however, longitudinal development has not been ...

    • Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma 

      Berg, Hege Fredriksen; Ju, Zhenlin; Myrvold, Madeleine; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Høivik, Erling Andre; Westin, Shannon; Trovik, Jone; Haldorsen, Ingfrid S.; Mills, Gordon B.; Krakstad, Camilla; Werner, Henrica Maria Johanna (Journal article; Peer reviewed, 2020-02-10)
      Background In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed to develop models ...