Browsing Department of Clinical Science by Title
Now showing items 64-83 of 2323
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Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
(Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
(Journal article; Peer reviewed, 2022)Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ... -
Analytical considerations in deriving 99th percentile upper reference limits for high-sensitivity cardiac troponin assays: Educational recommendations from the IFCC committee on clinical application of cardiac bio-markers
(Journal article; Peer reviewed, 2022)The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization of cardiac ... -
Analytical performance of cardiac troponin assays – Current status and future needs
(Journal article; Peer reviewed, 2020)Concurrent with the introduction of cardiac troponin measurements into the diagnostic definition of myocardial infarction (MI), clinicians and laboratory professionals signaled a clear clinical need for improved analytical ... -
Anatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflows
(Peer reviewed; Journal article, 2017-09-13)Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass ... -
Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans
(Journal article; Peer reviewed, 2020-04)HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ... -
Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival
(Peer reviewed; Journal article, 2017)Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard ... -
Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome
(Journal article; Peer reviewed, 2021)Background Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a ... -
Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero
(Journal article; Peer reviewed, 2023)Introduction: Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born ... -
Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease
(Journal article; Peer reviewed, 2021)Fatigue is common in all chronic inflammatory and autoimmune diseases. A conceptual model for understanding the biological basis of fatigue describes it as being a part of the sickness behaviour response generated by ... -
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
(Peer reviewed; Journal article, 2006-06-13)Background The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive AIRE mutations lead to autoimmunity targetting ... -
Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia
(Peer reviewed; Journal article, 2016-12-01)Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome ... -
Antibiotic Use in a Cohort of Norwegian Children and Neonates Before, During and After Hospitalisation : Exploring focus areas for antibiotic stewardship
(Doctoral thesis, 2022-11-22)Bakgrunn: Rasjonell antibiotikabruk blant barn er essensielt for å unngå økende antibiotikaresistens samt forstyrrelser i deres normale bakterieflora. Formål: Hensikten med dette prosjektet var å tilegne oss en bedre ... -
Antibiotic use in children before, during and after hospitalisation
(Journal article; Peer reviewed, 2022)Purpose: To investigate ambulatory antibiotic use in children during 1 year before and 1 year after in-hospital antibiotic exposure compared to children from the general population that had not received antibiotics ... -
Antibiotika og antibakteriellsubstans, ciprofloxacin og triclosan i jord og husdyrgjødsel
(Master thesis, 2009-05-20)The goal of this thesis was to get a better understanding of how triclosan and ciprofloxacin behave in the environment, and also to see if a contamination of these substances exists in a variety of matrixes. The objective ... -
Antibiotika – forbruk og bivirkningsmeldinger i Norge 2012 – 2019. En oppfølging av Nasjonal strategi mot antibiotikaresistens 2015 – 2020
(Master thesis, 2020-06-18)Bakgrunn: Utvikling av antibiotikaresistens akselereres ved bruk av antibiotika, og er et økende globalt problem. Et sentralt tiltak i arbeidet mot antibiotikaresistens er å redusere bruken av antibiotika, og spesielt ... -
Antibiotikabehandling ved KOLS-forverring ved Haukeland Universitetssykehus
(Master thesis, 2022-05-20) -
Antibiotikabehandling ved samfunnservervet pneumoni i sykehus
(Master thesis, 2022-05-20) -
Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self-reported severity and duration of illness
(Peer reviewed; Journal article, 2018-12-09)Background: A population‐based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy. Objectives: We studied maternal ... -
Antibody responses after influenza and SARS-CoV-2 vaccination and infection: Lessons across the ages
(Doctoral thesis, 2023-10-23)Influensa A og SARS-CoV-2 er RNA-baserte luftvegsvirus som forårsakar pandemiar og muterer raskt for å oppretthalde ein kontinuerleg sirkulasjon. Eit komplekst samspel mellom immunresponsar hjå verten og viruset er forma ...