Now showing items 754-773 of 1205

    • Micronutrients in paediatric Intestinal Failure Patients receiving home parenteral nutrition 

      Thomassen, Rut Anne; Kvammen, Janne Anita; Sæland, Camilla; Kjeserud, Christina; Eikeland, Joakim; Juliusson, Petur Benedikt; Bentsen, Beint Sigmund; Henriksen, Christine (Journal article; Peer reviewed, 2020-11)
      Background & aims Children with intestinal failure (IF) receive parental nutrition to ensure adequate growth and development. The aim of this study was to assess micronutrient status in paediatric IF patients receiving ...
    • MicroRNAs enrichment in GWAS of complex human phenotypes 

      Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, AJ; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas; Djurovic, Srdjan (Peer reviewed; Journal article, 2015-04-16)
      Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ...
    • A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats 

      Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2019-09-24)
      A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ...
    • Modeling psychiatric disorders: From genomic findings to cellular phenotypes 

      Falk, Anna; Heine, Vivi M.; Harwood, Adrian J.; Sullivan, Patrick F.; Peitz, Michael; Brüstle, Oliver; Shen, Sanbring; Sun, Yuh-Man; Glover, Joel; Posthuma, Daniëlle; Djurovic, Srdjan (Peer reviewed; Journal article, 2016)
      Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly ...
    • Modes of e-Health delivery in secondary prevention programmes for patients with coronary artery disease: A systematic review 

      Brørs, Gunhild; Pettersen, Trond Røed; Hansen, Tina B.; Fridlund, Bengt Gotthard Anton; Hølvold, Linn Benjaminsen; Lund, Hans; Norekvål, Tone M. (Peer reviewed; Journal article, 2019-06-10)
      Background: Electronic health (e-Health) interventions are emerging as an effective alternative model for improving secondary prevention of coronary artery disease (CAD). The aim of this study was to describe the effectiveness ...
    • Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells 

      Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Peer reviewed; Journal article, 2019)
      Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ...
    • Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia 

      Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre; Kopperud, Reidun Kristin; Sjøholt, Gry; Bruserud, Øystein; McCormack, Emmet; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2019)
      Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ...
    • Molecular alterations suggesting new treatment strategies in uterine carcinomas 

      Halle, Mari Kyllesø (Doctoral thesis, 2017-11-10)
    • Molecular characterization of Corynebacterium diphtheriae isolates, Russia, 1957-1987 

      Skogen, Vegard; Cherkasova, Valentina; Maksimova, Nina; Marston, Chung K.; Sjursen, Haakon; Reeves, Michael W.; Olsvik, Ørjan; Popovic, Tanja (Peer reviewed; Journal article, 2002)
      In the 1990s, the Newly Independent and Baltic States of the former Soviet Union experienced the largest diphtheria outbreak since the 1960s; it was caused by Corynebacterium diphtheriae strains of a unique clonal group. ...
    • Molecular markers to predict prognosis and guide therapy in endometrial cancer 

      Engerud, Hilde Renate (Doctoral thesis, 2020-02-07)
      Background: Endometrial cancer is the most common gynecological malignancy in the Western world. The disease occurs in the epithelial lining of the uterus, called the endometrium. Although prognosis is good and most of the ...
    • Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia 

      Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode S.; Reikvam, Håkon; Fredly, Hanne Kristin; Haugse, Ragnhild; Thiede, Bernd; McCormack, Emmet; Lain, Sonia; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2014-05-21)
      Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ...
    • Molecular mechanisms of sonoporation in cancer therapy : Optimization of sonoporation parameters and investigations of intracellular signalling 

      Haugse, Ragnhild (Doctoral thesis, 2020-06-17)
      Background: Sonoporation, which is treatment with ultrasound (US) and microbubbles (MB), has shown great potential for enhancing the therapeutic efficacy of chemotherapy in cancer therapy. However, there is still very ...
    • Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer 

      Alonso-Alconada, Lorena; Muinelo-Romay, Laura; Madissoo, Kadri; Diaz-Lopez, Antonio; Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth; Hapangama, Dharani; Coenegrachts, Lieve; Cano, Amparo; Gil-Moreno, Antonio; Chiva, Luis; Cueva, Juan; Vieito, Maria; Ortega, Eugenia; Mariscal, Javier; Colas, Eva; Castellvi, Josep; Cusido, Maite; Dolcet, Xavier; Nijman, Hans W.; Bosse, Tjalling; Green, John A.; Romano, Andrea; Reventos, Jaume; Lopez-Lopez, Rafael; Salvesen, Helga Birgitte; Amant, Frederic; Matias-Guiu, Xavier; Moreno-Bueno, Gema; Abal, Miguel; on behalf of ENITEC Consortium (Peer reviewed; Journal article, 2014-09-27)
      Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ...
    • Monitoring children and adolescents with severe obesity: body mass index (BMI), BMI z‐score or percentage above the International Obesity Task Force overweight cut‐off? 

      Løkling, Hanne L; Roelants, Mathieu; Kommedal, Kristin; Skjåkødegård, Hanna Flækøy; Apalset, Ellen M; Benestad, Beate; Morken, Mette Helvik; Hjelmesæth, Jøran; Juliusson, Petur Benedikt (Peer reviewed; Journal article, 2019)
      Aim: Body mass index (BMI) metrics are widely used as a proxy for adiposity in children with severe obesity. The BMI expressed as the percentage of a cut‐off percentile for overweight or obesity has been proposed as a ...
    • Monitoring multiple myeloma by quantification of recurrent mutations in serum 

      Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Peer reviewed; Journal article, 2017)
      Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ...
    • The monocyte system in haematological malignancies 

      Rundgren, Ida Marie (Doctoral thesis, 2020-04-17)
      Monocytes consist of classical, intermediate, and non-classical monocytes. In haematological malignancies, such as multiple myeloma and acute myeloid leukaemia, monocytes are affected by both the disease itself and the ...
    • Monocyte-derived dendritic cells in cancer immunotherapy : Considerations on their applicability 

      Yi, Dag Heiro (Doctoral thesis, 2021-02-17)
      Cancer is the leading cause of death in the developed world. While treatment options and detection have improved over the last century, mortality rate remains high especially in metastatic disease. Traditional treatment ...
    • Morphine enhances doxorubicin-induced cardiotoxicity in the rat 

      Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2014-09)
      Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant. Pharmacological preconditioning mimicking ischemic preconditioning has been demonstrated with morphine and represents an acceptable clinical ...
    • Mortality related to hospital-associated infections in a tertiary hospital; repeated cross-sectional studies between 2004-2011 

      Koch, Anne Mette; Nilsen, Roy Miodini; Eriksen, Hanne-Merete; Cox, Rebecca Jane; Harthug, Stig (Peer reviewed; Journal article, 2015-12-29)
      Background: Hospital-associated infections (HAIs) are reported to increase patient mortality and incur longer hospital stays. Most studies to date have focused on specific groups of hospitalised patients with a rather short ...
    • Motivation and response rates in bronchoscopy studies 

      Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal; Leiten, Elise Orvedal; Nordeide, Eli; Bakke, Per S.; Lehmann, Sverre; Nielsen, Rune (Peer reviewed; Journal article, 2019-05-02)
      Background Bronchoscopy is frequently used to sample the lower airways in lung microbiome studies. Despite being a safe procedure, it is associated with discomfort that may result in reservations regarding participation ...