Now showing items 2244-2263 of 2305

    • VACCELERATE Site Network: Real-time definition of clinical study capacity in Europe 

      Salmanton-García, Jon; Wipfler, Pauline; Valle-Simón, Paula; Merakou, Christina; Kopsidas, Ioannis; Bethe, Ullrich; Steinbach, Angela; Spivak, Orly; Součková, Lenka; Mendonça, Maria Amélia; Koniordou, Markela; Hellemans, Margot; Frías-Iniesta, Jesus; Davis, Ruth Joanna; Barta, Imre; Azzini, Anna Maria; Askling, Helena H.; Argyropoulos, Christos D.; Álvarez-Barco, Elena; Akova, Murat; Bonten, Marc M.J.; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Flisiak, Robert; Husa, Petr; Jancoriene, Ligita; Koscalova, Alena; Launay, Odile; Lundgren, Jens; Mallon, Patrick; Marques, Laura; Nauclér, Pontus; Ochando, Jordi; Pana, Zoi-Dorothea; Tacconelli, Evelina; Tóth, Krisztina; Trelle, Sven; van Damme, Pierre; Zaoutis, Theoklis E.; Zeitlinger, Markus; Albus, Kerstin; Stewart, Fiona A.; Hofstraat, Sanne H.I.; Bruijning-Verhagen, Patricia; Cornely, Oliver A. (Journal article; Peer reviewed, 2023)
      Background: The inconsistent European vaccine trial landscape rendered the continent of limited interest for vaccine developers. The VACCELERATE consortium created a network of capable clinical trial sites throughout Europe. ...
    • VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment 

      Salmanton-García, Jon; Stewart, Fiona A.; Heringer, Sarah; Koniordou, Markela; Álvarez-Barco, Elena; Argyropoulos, Christos D.; Themistocleous, Sophia C.; Valle-Simón, Paula; Spivak, Orly; Součková, Lenka; Merakou, Christina; Amélia Mendonça, Maria; Joanna Davis, Ruth; Maria Azzini, Anna; Askling, Helena H.; Vene, Sirkka; Van Damme, Pierre; Steinbach, Angela; Shiamakkides, George; Seidel, Danila; Olesen, Ole F.; Noula, Evgenia; Macken, Alan; Luís, Catarina; Leckler, Janina; Launay, Odile; Isitt, Catherine; Hellemans, Margot; Frías-Iniesta, Jesús; Di Marzo, Romina; Carcas, Antonio J.; Boustras, George; Borobia, Alberto M.; Barta, Imre; Albus, Kerstin; Akova, Murat; Ochando, Jordi; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Husa, Petr; Jancoriene, Ligita; Mallon, Patrick; Marques, Laura; Mellinghoff, Sibylle C.; Nauclér, Pontus; Tacconelli, Evelina; Tóth, Krisztina; Zaoutis, Theoklis E.; Zeitlinger, Markus; Cornely, Oliver A.; Pana, Zoi-Dorothea (Journal article; Peer reviewed, 2022)
      Introduction: The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases and to provide efficient ...
    • Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies 

      Wolff, Anette Susanne Bøe; Hansen, Lena; Grytaas, Marianne Aardal; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Zhou, Fan; Hufthammer, Karl Ove; Sjøgren, Thea; Olofsson, Jan Stefan; Trieu, Mai Chi; Meager, Anthony; Jørgensen, Anders Palmstrøm; Lima, Kari; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox Brokstad, Rebecca Jane; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      A hallmark of patients with autoimmune polyendocrine syndrome type 1 (APS-1) is serological neutralizing autoantibodies against type 1 interferons (IFN-I). The presence of these antibodies has been associated with severe ...
    • Vaccination rates in Europe are not associated with online media intensity 

      Luís, Catarina; Di Marzo, Verónica Romina; Kaur, Mandeep; Argyropoulos, Christos D.; Devane, Declan; Stewart, Fiona A.; Antoniou, George; Hendrickx, Greet; Askling, Helena Hervius; Hellemans, Margot; Cohen, Miriam; Spivak, Orly; Damme, Pierre Van; Cox, Rebecca Jane; Vene, Sirkka; Sibia, Sofie; Pana, Zoi Dorothea; Olesen, Ole F. (Journal article; Peer reviewed, 2022)
      To map the public information about COVID-19 vaccines and vaccine trials in Europe, we have compiled an inventory of online communication materials from official sources (e.g., governments, public agencies, and NGOs) via ...
    • Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice 

      Wohlbold, Teddy John; Nachbagauer, Raffael; Xu, Haoming; Tan, Gene S.; Hirsh, Ariana; Brokstad, Karl Albert; Cox, Rebecca Jane; Palese, Peter; Krammer, Florian (Peer reviewed; Journal article, 2015-03-10)
      In an attempt to assess the cross-protective potential of the influenza virus neuraminidase (NA) as a vaccine antigen, different subtypes of recombinant NA were expressed in a baculovirus system and used to vaccinate mice ...
    • Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity 

      Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez; Aasebø, Elise; Berven, Frode Steingrimsen; Selheim, Frode; Brenner, Annette; Rye, Kristin Paulsen; Hagen, Marie; Reikvam, Håkon; Mc Cormack, Emmet; Bruserud, Øystein; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)
      Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a ...
    • Validation of a Harmonized Enzyme-Linked-Lectin-Assay (ELLA-NI) Based Neuraminidase Inhibition Assay Standard Operating Procedure (SOP) for Quantification of N1 Influenza Antibodies and the Use of a Calibrator to Improve the Reproducibility of the ELLA-NI With Reverse Genetics Viral and Recombinant Neuraminidase Antigens: A FLUCOP Collaborative Study 

      Bernard, Marie-Clotilde; Waldock, Joanna; Commandeur, Sylvie; Strauß, Lea; Trombetta, Claudia Maria; Marchi, Serena; Zhou, Fan; van de Witte, Serge; van Amsterdam, Peter; Ho, Sammy; Hoschler, Katja; Lugovtsev, Vladimir; Weir, Jerry P.; Montomoli, Emanuele; Cox, Rebecca Jane; Engelhardt, Othmar G.; Friel, Damien; Wagner, Ralf; Ollinger, Thierry; Germain, Sophie; Sediri-Schön, Hanna (Journal article; Peer reviewed, 2022)
      Current vaccination strategies against influenza focus on generating an antibody response against the viral haemagglutination surface protein, however there is increasing interest in neuraminidase (NA) as a target for ...
    • Validation of a modified South African triage scale in a high-resource setting: a retrospective cohort study 

      Markussen, Dagfinn Lunde; Brevik, Heidi Synnøve; Bjørneklett, Rune Oskar; Engan, Mette (Journal article; Peer reviewed, 2023-03-20)
      Background: Triage systems are widely used in emergency departments, but are not always validated. The South African Triage Scale (SATS) has mainly been studied in resource-limited settings. The aim of this study was to ...
    • Validation of Chichewa short musculoskeletal function assessment (SMFA) questionnaire: A cross-sectional study 

      Chokotho, Linda; Lau, Brian C.; Conway, Devin; Wu, Hao-Hua; Shearer, David; Hallan, Geir; Gjertsen, Jan-Erik; Mkandawire, Nyengo; Young, Sven (Peer reviewed; Journal article, 2019-03)
      Background: The Short Musculoskeletal Function Assessment (SMFA) tool measures function and quality of life in patients with musculoskeletal conditions. Objective: This study aimed to translate and adapt culturally the ...
    • The valine-3-HIB pathway in obesity, insulin resistance and fatty liver 

      Bjune, Mona Synnøve (Doctoral thesis, 2022-06-10)
      The prevalence of obesity has increased greatly during the last decades, along with obesity-associated conditions and diseases including insulin resistance, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD). ...
    • The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure 

      Pandhi, Paloma; Streng, Koen W.; Anker, Stefan D.; Cleland, John G.; Damman, Kevin; Dickstein, Kenneth; Pellicori, Pierpaolo; Lang, Chim C.; Ng, Leong; Samani, Nilesh J.; Zannad, Faiez; Metra, Marco; Rossignol, Patrick; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Voors, Adriaan A.; ter Maaten, Jozine M. (Journal article; Peer reviewed, 2021)
      Background Muscle wasting and unintentional weight loss (cachexia) have been associated with worse outcomes in heart failure (HF), but timely identification of these adverse phenomena is difficult. Spot urinary creatinine ...
    • Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA–DQ Locus 

      Trutschel, Diana; Bost, Pierre; Mariette, Xavier; Bondet, Vincent; Llibre, Alba; Posseme, Celine; Charbit, Bruno; Thorball, Christian W.; Jonsson, Roland; Lessard, Christopher J.; Felten, Renaud; Ng, Wan Fai; Chatenoud, Lucienne; Dumortier, Hélène; Sibilia, Jean; Fellay, Jacques; Brokstad, Karl Albert; Appel, Silke; Tarn, Jessica R; Quintana-Murci, Lluis; Mingueneau, Michael; Meyer, Nicolas; Duffy, Darragh; Schwikowski, Benno; Gottenberg, Jacques Eric (Journal article; Peer reviewed, 2022)
      Objective Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with ...
    • Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration 

      Liu, Xueping; Helenius, Dorte; Skotte, Line; Beaumont, Robin N.; Wielscher, Matthias; Geller, Frank; Juodakis, Julius; Mahajan, Anubha; Bradfield, Jonathan P.; Lin, Frederick T.J.; Vogelezang, Suzanne; Bustamante, Mariona; Ahluwalia, Tarunveer S.; Pitkänen, Niina; Wang, Carol A.; Bacelis, Jonas; Borges, Maria C.; Zhang, Ge; Bedell, Bruce A.; Rossi, Robert M.; Skogstrand, Kristin; Peng, Shouneng; Thompson, Wesley Kurt; Appadurai, Vivek; Lawlor, Debbie A.; Kalliala, Ilkka; Power, Christine; McCarthy, Mark I.; Boyd, Heather A.; Marazita, Mary L.; Hakonarson, Hakon; Hayes, M. Geoffrey; Scholtens, Denise M.; Rivadeneira, Fernando; Jaddoe, Vincent W.V.; Vinding, Rebecca K.; Bisgaard, Hans; Knight, Bridget A.; Pahkala, Katja; Raitakari, Olli; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Fadista, João; Schork, Andrew J.; Nudel, Ron; Miller, Daniel E.; Chen, Xiaoting; Weirauch, Matthew T.; Mortensen, Preben Bo; Børglum, Anders D.; Nordentoft, Merete; Mors, Ole; Hao, Ke; Ryckman, Kelli K.; Hougaard, David M.; Kottyan, Leah C.; Pennell, Craig E.; Lyytikäinen, Leo-Pekka; Bønnelykke, Klaus; Vrijheid, Martine; Felix, Janine F.; Lowe, William L.; Grant, Struan F.A.; Hyppönen, Elina; Jacobsson, Bo; Jarvelin, Marjo-Riitta; Muglia, Louis J.; Murray, Jeffrey C.; Freathy, Rachel M.; Werge, Thomas M.; Melbye, Mads; Buil, Alfonso; Feenstra, Bjarke (Peer reviewed; Journal article, 2019-09-02)
      The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ...
    • Variasjoner i bruk av psykofarmaka ved sykehjem i Trondheim kommune 

      Hjortland, Anja (Master thesis, 2019-06-22)
      Sykehjemspasientene er blant den skjøreste pasientpopulasjonen, mer enn 80% av sykehjemspasienter har demens, og flere av disse bruker en eller flere psykotrope legemidler daglig. Når kroppen blir eldre er det mye som ...
    • Vascular endothelial function assessed by flow-mediated vasodilatation in young adults born very preterm or with extremely low birthweight: A regional cohort study 

      Engan, Britt; Engan, Mette; Greve, Gottfried; Vollsæter, Maria; Hufthammer, Karl Ove; Leirgul, Elisabeth (Journal article; Peer reviewed, 2021)
      Background: Preterm birth and low birthweight have been associated with increased risk of cardiovascular disease in young adults. Endothelial dysfunction is established as an early marker for development of atherosclerotic ...
    • Vascular normalisation as the stepping stone into tumour microenvironment transformation 

      Magnussen, Anette L.; Mills, Ian (Journal article; Peer reviewed, 2021)
      A functional vascular system is indispensable for drug delivery and fundamental for responsiveness of the tumour microenvironment to such medication. At the same time, the progression of a tumour is defined by the interactions ...
    • Vegan diet and bone health—results from the cross-sectional RBVD study 

      Menzel, Juliane; Abraham, Klaus; Stangl, Gabriele I.; Ueland, Per Magne; Obeid, Rima; Schulze, Matthias B.; Herter-Aeberli, Isabelle; Schwerdtle, Tanja; Weikert, Cornelia (Journal article; Peer reviewed, 2021)
      Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with ...
    • Ventilator flow data predict bronchopulmonary dysplasia in extremely premature neonates 

      Bentsen, Mariann; Markestad, Trond; Halvorsen, Thomas (Journal article; Peer reviewed, 2018)
      Early prediction of bronchopulmonary dysplasia (BPD) may facilitate tailored management for neonates at risk. We investigated whether easily accessible flow data from a mechanical ventilator can predict BPD in neonates ...
    • Ventilatory efficiency in children and adolescents born extremely preterm 

      Hestnes, Julie; Hoel, Hedda Benedicte; Risa, Ole J.; Romstøl, Hanna O.; Røksund, Ola Drange; Frisk, Bente; Thorsen, Einar; Halvorsen, Thomas; Clemm, Hege Synnøve Havstad (Peer reviewed; Journal article, 2017-07-13)
      Purpose: Children and adolescents born extremely preterm (EP) have lower dynamic lung volumes and gas transfer capacity than subjects born at term. Most studies also report lower aerobic capacity. We hypothesized that ...
    • Vinorelbine and gemcitabine vs vinorelbine and carboplatin as first-line treatment of advanced NSCLC. A phase III randomised controlled trial by the Norwegian Lung Cancer Study Group 

      Fløtten, Øystein; Grønberg, Bjørn Henning; Bremnes, Roy M.; Amundsen, Tore; Sundstrøm, Stein Harald; Rolke, Heidi; Hornslien, Kjersti; Wentzel-Larsen, Tore; Aasebø, Ulf; von Plessen, Christian (Journal article; Peer reviewed, 2012)
      Background: Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective ...