Browsing Department of Clinical Science by Title

Now showing items 41-60 of 2567

    • Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats 

      Leh, Sabine Maria; Hultström, Michael; Rosenberger, Christian; Iversen, Bjarne M. (Peer reviewed; Journal article, 2011-06-10)
      In chronic renal disease, the temporal and spatial relationship between vascular, glomerular and tubular changes is still unclear. Hypertension, an important cause of chronic renal failure, leads to afferent arteriolopathy, ...

    • Age specific aetiological agents of diarrhoea in hospitalized children aged less than five years in Dar es Salaam, Tanzania 

      Moyo, Sabrina John; Njølstad, Gro; Matee, Mecky I.; Kitundu, Jesse; Myrmel, Helge; Mylvaganam, Haima; Maselle, Samwel Y.; Langeland, Nina (Peer reviewed; Journal article, 2011-02-23)
      Background This study aimed to determine the age-specific aetiologic agents of diarrhoea in children aged less than five years. The study also assessed the efficacy of the empiric treatment of childhood diarrhoea using ...

    • Age-related differences in self-report and objective measures of cognitive function in older patients prior to chemotherapy 

      Utne, Inger; Løyland, Borghild; Grov, Ellen Karine; Rasmussen, Hege Lund; Torstveit, Ann Helen; Paul, Steven M.; Lindemann, Kristina Yvonne Kathe; Vistad, Ingvild; Rodriguez-Aranda, Claudia; Miaskowski, Christine (Journal article; Peer reviewed, 2021)
      Aim Evaluate for differences in demographic and clinical characteristics and subjective and objective measures of cognitive function (CF) between younger older adults (YOA, 60–69 years) and older adults (OA, ≥70 ...

    • Aiming towards evidence based interpretation of cardiac biomarkers in patients presenting with chest pain : The WESTCOR study 

      Tjora, Hilde Lunde (Doctoral thesis, 2022-08-23)
      Bakgrunn: Ca 10% av alle pasientar i akuttmottak blir innlagt med brystsmerter og spørsmål om akutt koronarsyndrom (AKS), men under ¼ av pasientane har AKS. Metode:WESTCOR studien er ein prospektiv observasjonsstudie som ...

    • Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design 

      Thulin, Ingrid Viola Lavesson; Jordalen, Silje Marie Farestveit; Lekven, Ole Christian; Krishnapillai, Jeyaseelan; Steiro, Ole-Thomas; Collinson, Paul; Apple, Fred; Cullen, Louise; Norekvål, Tone Merete; Wisløff, Torbjørn; Vikenes, Kjell; Omland, Torbjørn; Bjørneklett, Rune Oskar; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2023)
      Objectives: Patients presenting with symptoms suggestive of acute coronary syndrome (ACS) contribute to a high workload and overcrowding in the Emergency Department (ED). Accelerated diagnostic protocols for non-ST-elevation ...

    • Airway Inflammation and Bronchial Remodelling in Toluene Diisocyanate-exposed BALB/c Mouse Model 

      Sun, Li-Zhi; Elsayed, S.; Bronstad, A. M.; Van Do, T.; Irgens, Ågot; Aardal, N. P.; Aasen, T. B. (Peer reviewed; Journal article, 2007)
      Toluene diisocyanate (TDI), a highly reactive industrial chemical, is one of the leading causes of occupation-related asthma in industrialized countries. The pathogenesis of TDI-induced asthma, however, remains not fully ...

    • The airway microbiota of stable COPD : Association with exacerbation frequency and the risks associated with bronchoscopic data collection 

      Leiten, Elise Orvedal (Doctoral thesis, 2022-03-25)
      Background: Acute exacerbations of COPD are an important cause of mortality and morbidity in patients with COPD. It is incompletely understood why some COPD patients experience frequent exacerbations, while others rarely ...

    • Airway obstruction, dynamic hyperinflation, and breathing pattern during incremental exercise in COPD patients 

      Frisk, Bente; Espehaug, Birgitte; Hardie, Jon Andrew; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (Peer reviewed; Journal article, 2014-02-01)
      Ventilatory capacity is reduced in chronic obstructive pulmonary disease (COPD) patients. Tidal volume (VT) is lower and breathing frequency higher at a given ventilation (VE) compared to healthy subjects. We examined ...

    • Airway symptoms and atopy in young children prescribed asthma medications: A large‐scale cohort study 

      Mikalsen, Ingvild Bruun; Dalen, Ingvild; Karlstad, Øystein; Eide, Geir Egil; Magnus, Maria Christine; Nystad, Wenche; Øymar, Knut (Peer reviewed; Journal article, 2019)
      Diagnosing asthma and deciding treatment are difficult in young children. An inappropriate and too high prescription rate of inhaled corticosteroids (ICS) is suggested, but how airway symptoms are associated with prescriptions ...

    • The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury 

      Aulin, C.; Larsson, S.; Vogl, T.; Roth, J.; Åkesson, A.; Swärd, P.; Heinbäck, R.; Harris, Helena Erlandsson; Struglics, A. (Journal article; Peer reviewed, 2022)
      Objective To compare the concentrations of high mobility group box 1 protein (HMGB1) and S100A8/A9 in synovial fluid between patients with knee injuries and osteoarthritis (OA), and knee healthy subjects. To investigate ...

    • Alcohol at bedtime induces minor changes in sleep stages and blood gases in stable chronic obstructive pulmonary disease 

      Holmedahl, Nils Henrik; Øverland, Britt; Fondenes, Ove; Ellingsen, Ivar; Hardie, Jon Andrew (Peer reviewed; Journal article, 2014-05-17)
      Purpose/background: The purpose of this study is to explore the effect of a moderate dose of alcohol on sleep architecture and respiration in chronic obstructive pulmonary disease (COPD). Alcohol depresses both hypercapnic ...

    • Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis 

      Singh, Yashbir; Jons, William A.; Eaton, John E.; Vesterhus, Mette Nåmdal; Karlsen, Tom Hemming; Bjørk, Ida; Abildgaard, Andreas; Jørgensen, Kristin Kaasen; Folseraas, Trine; Little, Derek; Gulamhusein, Aliya F.; Petrovic, Kosta; Negård, Anne; Conte, Gian Marco; Sobek, Joseph D.; Jagtap, Jaidip; Venkatesh, Sudhakar K.; Gores, Gregory J.; LaRusso, Nicholas F.; Lazaridis, Konstantinos N.; Erickson, Bradley J. (Journal article; Peer reviewed, 2022)
      Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to cirrhosis and hepatic decompensation. However, predicting future outcomes in patients with PSC is challenging. Our ...

    • All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors 

      Puppo, Francesca; Sadegh, Sanaz; Trujillo, Cleber A.; Thunemann, Martin; Campbell, Evan P.; Vandenberghe, Matthieu; Shan, Xiwei; Akkouh, Ibrahim; Miller, Evan W.; Bloodgood, Brenda L.; Silva, Gabriel A.; Dale, Anders M.; Einevoll, Gaute; Djurovic, Srdjan; Andreassen, Ole Andreas; Muotri, Alysson R.; Devor, Anna (Journal article; Peer reviewed, 2021)
      Voltage imaging and “all-optical electrophysiology” in human induced pluripotent stem cell (hiPSC)-derived neurons have opened unprecedented opportunities for high-throughput phenotyping of activity in neurons possessing ...

    • Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients 

      Ryberg, D.; Tefre, T.; Skaug, V.; Stangeland, Lodve; Øvrebø, S.; Naalsund, A.; Børresen, A.-L.; Haugen, Aa. (Peer reviewed; Journal article, 1992-11)
      We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot ...

    • Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations 

      Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Einevoll, Gaute (Peer reviewed; Journal article, 2019-02)
      Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ...

    • Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery 

      Sinturel, Flore; Chera, Simona; Brulhart-Meynet, Marie-Claude; Montoya, Jonathan Paz; Lefai, Etienne; Jornayvaz, François R.; D’Angelo, Giovanni; Jung, Minoa Karin; Pataky, Zoltan; Riezman, Howard; Dibner, Charna (Journal article; Peer reviewed, 2024)
      Besides its beneficial effect on weight loss, gastric bypass surgery (GBS) may impact the circulating levels of phospho- and sphingolipids. However, long-term effects have not been explored. To investigate alterations in ...

    • Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study 

      Sævik, Åse Bjorvatn; Ueland, Grethe Åstrøm; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Höybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Kämpe, Olle; Bensing, Sophie; Husebye, Eystein Sverre; Øksnes, Marianne (Journal article; Peer reviewed, 2023)
      Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood. Design: Cross-sectional study. Methods: We compared serum ...

    • Altered Blood Molecular Markers of Cardiovascular Function in Rats after Intrauterine Hypoxia and Drug Therapy 

      Popazova, Olena; Belenichev, Igor; Yadlovskyi, Oleh; Oksenych, Valentyn; Kamyshnyi, Aleksandr (Journal article; Peer reviewed, 2023)
      Many children and adults who have suffered prenatal hypoxia at an early age develop many serious diseases. This disease is an actual problem of pediatric cardiology and little studied. The aim was to analyze the cardioprotective ...

    • Altered development of fetal liver perfusion in pregnancies with pregestational diabetes 

      Lund, Agnethe; Ebbing, Cathrine; Rasmussen, Svein; Kiserud, Torvid; Hanson, Mark; Kessler, Jørg (Peer reviewed; Journal article, 2019-03-13)
      Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal ...

    • Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...