Browsing Department of Clinical Science by Issue Date
Now showing items 41-60 of 2478
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Tentative longterm effects of a noradrenergic antidepressant; affecting the number of glucose transporters
(Master thesis, 2008-06-01)Major depressive disorder is an affective disorder affecting millions of people worldwide. Only in Europe at least 21 million are thought to be affected. Several theories have been developed during the years trying to ... -
Undersøke sammenhengen mellom jernstatus og jernabsorpsjon. Sammenligning av friske og pasienter med hemokromatose
(Master thesis, 2008-06-01)Jern er et essensielt spormetall som vi har ca 3-4 g av i kroppen. Jern inngår i flere proteiner, der hemoglobin er det viktigste. Jern er også delaktig i flere redoksreaksjoner i kroppen vår. Vi trenger daglig et tilskudd ... -
In vitro cytotoksisk effekt av venom fra vestlig honningbie (Apis mellifera) hos glioblastoma cellelinjer av typen U251 og C6.
(Master thesis, 2008-06-01)Flere in vitro-metoder kan benyttes til å evaluere både generell og organspesifikk toksisitet. Disse metodene kan kombineres med bioprospektering for å screene mulige legemidler for cytotoksisk effekt, og samtidig begrense ... -
Formulering av kortisonpreparat til bruk ved binyrebarksvikt
(Master thesis, 2008-06-01) -
UGT1A4 og UGT2B15 enkeltnukleotidpolymorfismer. Etablering av real time PCR metoder og betydning for tamoxifen metabolisme
(Master thesis, 2008-06-02)Brystkreft er den vanligste kreftformen blant kvinner i Norge og adjuvant tamoxifenbehandling er vist å øke tilbakefallsfri og total overlevelse. Den interinidividuelle varaiasjonen i effekt og bivirkninger av tamoxifen ... -
Markedsføring av naturmidler- en vurdering
(Master thesis, 2008-06-02)Hensikten med oppgaven var å undersøke og sammenligne markedsføringen av naturmidler i kommunikasjonskanalene apotek, helsekostforretninger, Internett, ukeblad og magasiner. I løpet av ti uker ble det samlet inn annonser, ... -
Studies on homocysteine-lowering B-vitamin therapy in patients with coronary artery diseas : sub-studies from the Western Norway B-vitamin intervention trial (WENBIT)
(Doctoral thesis, 2008-06-06)Background: A high plasma level of total homocysteine (tHcy) is a risk factor for cardiovascular disease, and is related to important components of atherosclerosis such as inflammation and endothelial dysfunction. Objectives: ... -
A Pilot Evaluation of p53 Activating Therapy as a Novel Strategy in the Treatment of Acute Myeloid Leukaemia
(Master thesis, 2008-06-08)p53 is a tumour suppressor protein involved in maintenance of genomic stability of the cell. Primarily, p53 protects the cell from malignant transformation through cell cycle arrest and apoptosis. While mutations in p53 ... -
Peroxisome proliferator-activated receptors (PPARs) and mitochondria in relation to lifestyle-related diseases
(Doctoral thesis, 2008-06-17)Obesity is a growing life-style related health problem, and is often accompanied by dyslipidemia, insulin resistance and inflammation. This may in turn lead to hyperinsulinemia, increased risk of non-alcoholic fatty liver ... -
High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example
(Peer reviewed; Journal article, 2008-07-02)Background: While the genomic annotations of diverse lineages of the Mycobacterium tuberculosis complex are available, divergences between gene prediction methods are still a challenge for unbiased protein dataset generation. ... -
Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies
(Peer reviewed; Journal article, 2008-07-16)Background: Conventionally, the pregnancy duration is accepted to be 280–282 days. Fetuses determined by ultrasound biometry to be small in early pregnancy, have an increased risk of premature birth. We speculate that the ... -
Adenosine Deaminase Activity Is a Sensitive Marker for the Diagnosis of Tuberculous Pleuritis in Patients with Very Low CD4 Counts
(Peer reviewed; Journal article, 2008-07-30)Background: Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive ... -
Early life environment and snoring in adulthood
(Peer reviewed; Journal article, 2008-08-22)Background: To our knowledge, no studies of the possible association of early life environment with snoring in adulthood have been published. We aimed to investigate whether early life environment is associated with snoring ... -
CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer
(Peer reviewed; Journal article, 2008-08-26)Background: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis ... -
Predictors of long time survival after lung cancer surgery. A retrospective cohort study.
(Peer reviewed; Journal article, 2008-10-27)Background: There have been few reports regarding long time survival after lung cancer surgery. The influence of age and pulmonary function on long time survival is still not fully discovered. Some reports suggest that ... -
Resistance to Chemotherapy in Breast Cancer: Potential role of p21B, p27 and the p53 apoptotic pathway
(Doctoral thesis, 2009-03-13) -
A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci
(Peer reviewed; Journal article, 2009-03-20)There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ... -
Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPAR gamma agonist pioglitazone
(Peer reviewed; Journal article, 2009-03-30)Background: All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has been shown to decrease bone mass in mice and thiazolidinediones (TZDs) ... -
Development of functional gastrointestinal disorders after Giardia lamblia infection
(Peer reviewed; Journal article, 2009-04-21)Background: Functional gastrointestinal disorders (FGID) may occur following acute gastroenteritis. This long-term complication has previously not been described after infection with the non-invasive protozoan Giardia ...