Blar i Department of Clinical Science på forfatter "García de Jalón, Elvira"
-
Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model
García de Jalón, Elvira; Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; Bjørge, Line; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)Purpose Fluorescence imaging (FLI) using targeted near-infrared (NIR) conjugates aids the detection of tumour lesions pre- and intraoperatively. The optimisation of tumour visualisation and contrast is essential and can ... -
CytoCy5S™, a compound of many structures. in vitro and in vivo evaluation of four near-infrared fluorescent substrates of nitroreductase (NTR)
García de Jalón, Elvira; Ruiz de Garibay, Gorka; Haug, Bengt Erik; Mccormack, Emmet Matin (Journal article; Peer reviewed, 2021)CytoCy5S™, a quenched, red-shifted fluorescent probe, has been used to exploit the imaging potential of the nitroreductase (NTR) reporter gene platform. Its use has been reported in a number of publications, however there ... -
Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy
Ruiz de Garibay, Gorka; García de Jalón, Elvira; Stigen, Endre; Lund, Kjetil B.; Popa, Mihaela-Lucia; Davidson, Ben; Mayoral Safont, Mireia; Rygh, Cecilie Brekke; Espedal, Heidi; Barrett, Torill; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene ...