• Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...
    • Amniotic fluid arginine from gestational weeks 13 to 15 is a predictor of birth weight, length, and head circumference 

      Jenssen, Astrid Bjørke; Ueland, Per Magne; Monsen, Anne Lise Bjørke (Peer reviewed; Journal article, 2017-12-14)
      Arginine is a constituent of proteins and a precursor for polyamines and nitric oxide, and is essential for placentation, angiogenesis, and growth. Maternal plasma arginine concentrations are found to be lower in pregnancies ...
    • Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study 

      Van Parys, Anthea; Lysne, Vegard; Dierkes, Jutta; Nygård, Ottar Kjell; Øyen, Jannike; Vinknes, Kathrine Jørgensen; Karlsson, Therese; Haugsgjerd, Teresa Risan; Tell, Grethe S.; Ueland, Per Magne; Brække, Maria Sandvik (Journal article; Peer reviewed, 2022)
      Background: Choline is an essential nutrient for humans and is involved in various physiologic functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism, and the fat-soluble choline ...
    • The Association between Progression of Atherosclerosis and the Methylated Amino Acids Asymmetric Dimethylarginine and Trimethyllysine 

      Løland, Kjetil Halvorsen; Bleie, Øyvind; Borgeraas, Heidi; Strand, Elin; Ueland, Per Magne; Svardal, Asbjørn; Nordrehaug, Jan Erik; Nygård, Ottar (Peer reviewed; Journal article, 2013-05-29)
      Objective: We previously showed that treatment with folic acid (FA)/B12 was associated with more rapid progression of coronary artery disease (CAD). High doses of FA may induce methylation by increasing the availability ...
    • The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study 

      Luu, Hung N.; Paragomi, Pedram; Wang, Renwei; Huang, Joyce Y.; Adams-Haduch, Jennifer; Midttun, Øivind; Ulvik, Arve; Nguyen, Tin C.; Brand, Randall E.; Gao, Yutang; Ueland, Per Magne; Yuan, Jian-Min (Journal article; Peer reviewed, 2022-04-28)
      Background: Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic ...
    • Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging 

      Dugué, Pierre-Antoine; Hodge, Allison M.; Ulvik, Arve; Ueland, Per Magne; Midttun, Øyvind; Rinaldi, Sabina; MacInnis, Robert J.; Li, Sherly X.; Meyer, Klaus; Navionis, Anne-Sophie; Flicker, Leon; Severi, Gianluca; English, Dallas R.; Vineis, Paolo; Tell, Grethe S.; Southey, Melissa C.; Milne, Roger L.; Giles, Graham G. (Journal article; Peer reviewed, 2022)
      Background Inflammation is a key feature of aging. We aimed to (i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality and (ii) develop a signature of ...
    • Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine; Trøseid, Marius; Midttun, Øivind; Ueland, Per Magne; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Kummen, Martin; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background and aims Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio ...
    • B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris 

      Ding, Yunpeng; Pedersen, Eva Ringdal; Johansson, Stefan; Gregory III, Jesse F.; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Helgeland, Øyvind; Meyer, Klaus; Fredriksen, Åse; Nygård, Ottar (Peer reviewed; Journal article, 2016-06)
      Background: Methylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reactions that metabolize derivatives of tetrahydrofolate (THF) in folate-dependent one-carbon metabolism. Impaired MTHFD1 flux has ...
    • Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats. 

      Vikøren, Linn A.; Drotningsvik, Aslaug; Midttun, Øivind; McCann, Adrian; Bergseth, Marthe Tønder; Austgulen, Maren H.; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2021)
      Obesity is associated with changes in amino acid metabolism, and studies show that ingestion of fish proteins influence amino acid composition in plasma and urine, in addition to affecting risk factors for metabolic syndrome. ...
    • Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-Vitamin supplementation 

      Holm, Pål Ivar; Bleie, Øyvind; Ueland, Per Magne; Lien, Ernst Asbjørn; Refsum, Helga; Nordrehaug, Jan Erik; Nygård, Ottar (Peer reviewed; Journal article, 2004)
      Objective—Betaine is a substrate in the betaine– homocysteine methyltransferase reaction, converting homocysteine to methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine ...
    • Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes 

      Stone, Nicole; Pangilinan, Faith; Molloy, Anne M.; Shane, Barry; Scott, John M.; Ueland, Per Magne; Mills, James L.; Kirke, Peader N.; Sethupathy, Praveen; Brody, Lawrence C. (Peer reviewed; Journal article, 2011-07-12)
      One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ...
    • Biomarkers of inflammation and left ventricular remodelling in psoriasis patients treated with infliximab 

      Midtbø, Helga Bergljot; Kringeland, Ester Anne; Gerdts, Eva; Ueland, Per Magne; Meyer, Klaus; Linde, Anja G; Ulvik, Arve; Jonsson, Roland; Tveit, Kåre Steinar (Journal article; Peer reviewed, 2022)
      Objective: Psoriasis is an immune mediated disorder associated with T cell activation and cardiovascular disease (CVD). We explored the association of inflammation with left ventricular (LV) remodelling in psoriasis patients ...
    • Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study 

      Chuang, Shu-Chun; Boeing, Heiner; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Bueno-de-Mesquita, Bas; Lajous, Martin; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Kaaks, Rudolf; Küehn, Tilman; Pischon, Tobias; Drogan, Dagmar; Tjønneland, Anne; Overvad, Kim; Quirós, J. Ramón; Agudo, Antonio; Molina-Montes, Esther; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas J.; Travis, Ruth C.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H.; Weiderpass, Elisabete; Palmqvist, Richard; Ljuslinder, Ingrid; Gunter, Marc; Lu, Yunxia; Cross, Amanda J.; Riboli, Elio; Vineis, Paolo; Aleksandrova, Krasimira (Peer reviewed; Journal article, 2016-02-25)
      Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). ...
    • Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients 

      Watne, Leiv Otto; Pollmann, Christian Thomas; Neerland, Bjørn Erik; Quist-Paulsen, Else; Halaas, Nathalie Bodd; Idland, Ane-Victoria; Hassel, Bjørnar; Henjum, Kristi; Knapskog, Anne Brita; Frihagen, Frede; Ræder, Johan; Godø, Aasmund; Ueland, Per Magne; McCann, Adrian; Figved, Paul Wender; Selbæk, Geir; Zetterberg, Henrik; Fei Fang, Evandro; Myrstad, Marius; Giil, Lasse Melvær (Journal article; Peer reviewed, 2022)
      Background: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) ...
    • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

      Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Peer reviewed; Journal article, 2017-06)
      Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...
    • Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium 

      Muller, David C.; Larose, Tricia L; Hodge, Allison; Guida, Florence; Langhammer, Arnulf; Grankvist, Kjell; Meyer, Klaus; Cai, Qiuyin; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Albanes, Demetrius; Giles, Graham G.; Sesso, Howard D.; Lee, I-Min; Gaziano, J. Michael; Yuan, Jian-Min; Hoffman Bolton, Judith; Buring, Julie E.; Visvanathan, Kala; Le Marchand, Loic; Purdue, Mark P.; Caporaso, Neil E.; Midttun, Øivind; Ueland, Per Magne; Prentice, Ross L.; Weinstein, Stephanie J.; Stevens, Victoria L.; Zheng, Wei; Blot, William J.; Shu, Xiao-Ou; Zhang, Xuehong; Xiang, Yong-Bing; Koh, Woon-Puay; Hveem, Kristian; Thomson, Cynthia A.; Pettinger, Mary; Engström, Gunnar; Brunnström, Hans; Milne, Roger L.; Stampfer, Meir J.; Han, Jiali; Johansson, Mikael; Brennan, Paul; Severi, Gianluca; Johansson, Mattias (Peer reviewed; Journal article, 2019-01-03)
      Objectives: Inflammation may play an important role in lung cancer pathogenesis. Previous studies have suggested an association between C-reactive protein (CRP) as a marker of inflammation, and risk of lung cancer, but ...
    • Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease 

      Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Ørn, Stein; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)
      Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for ...
    • Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease 

      Bjørnestad, Espen Ø.; Olset, Hilde; Dhar, Indu; Løland, Kjetil Halvorsen; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Svardal, Asbjørn M.; Berge, Rolf K; Ueland, Per Magne; Tell, Grethe S.; Nilsen, Dennis W.T.; Jan E., Nordrehaug; Nygaard, Ellisif; Nygård, Ottar (Journal article; Peer reviewed, 2020)
      Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ...
    • Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort 

      Fanidi, Anouar; Muller, David C.; Midttun, Øivind; Ueland, Per Magne; Vollset, Stein Emil; Relton, Caroline; Vineis, Paolo; Weiderpass, Elisabete; Skeie, Guri; Brustad, Magritt; Palli, Domenico; Tumino, Rosario; Grioni, Sara; Sacerdote, Carlotta; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Cadeau, Claire; Huerta, José María; Sánchez, María-José; Agudo, Antonio; Lasheras, Cristina; Quirós, J. Ramón; Chamosa, Saioa; Riboli, Elio; Travis, Ruth C; Ward, Heather; Murphy, Neil; Khaw, Kay-Tee; Trichopoulou, Antonia; Lagiou, Pagona; Papatesta, Eleni-Maria; Boeing, Heiner; Kühn, Tilman; Katzke, Verena; Steffen, Annika; Johansson, Anders; Brennan, Paul; Johansson, Mattias (Peer reviewed; Journal article, 2016-11-04)
      Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective ...
    • Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation 

      Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin; Bossen, Lars; Engesæter, Lise Katrine; Reims, Henrik Mikael; Bjørk, Ida Torunn; Grzyb, Krzysztof; Abildgaard, Andreas; Småstuen, Milada Cvancarova; Folseraas, Trine; Trøseid, Marius; Ulvik, Arve; Ueland, Per Magne; Melum, Espen; Line, Pål Dag; Høivik, Marte Lie; Grønbæk, Henning; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2023)
      Background and aims We previously demonstrated that people with primary sclerosing cholangitis (PSC) had reduced gut microbial capacity to produce active vitamin B6 (pyridoxal 5’-phosphate [PLP]), which corresponded to ...