Browsing Department of Clinical Science by Journals "Journal of Biological Chemistry"
Now showing items 1-2 of 2
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A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
(Journal article; Peer reviewed, 2021)Breakpoint Cluster Region-Abelson kinase (BCR–Abl) is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for ... -
Identification and characterization of aptameric inhibitors of human neutrophil elastase
(Journal article; Peer reviewed, 2023)Human neutrophil elastase (HNE) plays a pivotal role in innate immunity, inflammation, and tissue remodeling. Aberrant proteolytic activity of HNE contributes to organ destruction in various chronic inflammatory diseases ...