Blar i Department of Clinical Science på tidsskrift "Molecular Psychiatry"
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Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
(Journal article; Peer reviewed, 2021)Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) ... -
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
(Peer reviewed; Journal article, 2018-10-02)The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex ... -
Genetic control of variability in subcortical and intracranial volumes
(Journal article; Peer reviewed, 2020)Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ... -
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
(Peer reviewed; Journal article, 2019)Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ... -
Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder
(Peer reviewed; Journal article, 2019)Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, ... -
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
(Journal article; Peer reviewed, 2023)A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. ... -
Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders
(Journal article; Peer reviewed, 2021)Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely ... -
Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood
(Journal article; Peer reviewed, 2022)Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ... -
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
(Journal article; Peer reviewed, 2023)Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ...