Blar i Department of Clinical Science på tidsskrift "PLOS ONE"

Viser treff 1-20 av 29

    • Activity monitoring and patient-reported outcome measures in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients 

      Rekeland, Ingrid Gurvin; Sørland, Kari; Bruland, Ove; Risa, Kristin; Alme, Kine; Dahl, Olav; Tronstad, Karl Johan; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2022-09-19)
      Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with no validated specific and sensitive biomarker, and no standard approved treatment. In this observational study with no intervention, ...

    • Analysing microbiome intervention design studies: Comparison of alternative multivariate statistical methods 

      Khomich, Maryia; Måge, Ingrid; Rud, Ida; Berget, Ingunn (Journal article; Peer reviewed, 2021)
      The diet plays a major role in shaping gut microbiome composition and function in both humans and animals, and dietary intervention trials are often used to investigate and understand these effects. A plethora of statistical ...

    • Children born preterm at the turn of the millennium had better lung function than children born similarly preterm in the early 1990s. 

      Vollsæter, Maria; Skromme, Kaia; Satrell, Emma; Clemm, Hege; Røksund, Ola; Øymar, Knut; Markestad, Trond; Halvorsen, Thomas (Peer reviewed; Journal article, 2015-12-07)
      Objective. Compare respiratory health in children born extremely preterm (EP) or with extremely low birthweight (ELBW) nearly one decade apart, hypothesizing that better perinatal management has led to better outcome. ...

    • Cytokine concentrations in plasma from children with severe and non-severe community acquired pneumonia 

      Haugen, Johanne; Chandyo, Ram Krishna; Brokstad, Karl Albert; Mathisen, Maria; Ulak, Manjeswori; Basnet, Sudha; Valentiner-Branth, Palle; Strand, Tor (Journal article; Peer reviewed, 2015-09-25)
      Background: Children in low and middle-income countries have a high burden of pneumonia. Measuring the cytokine responses may be useful to identify novel markers for diagnosing, monitoring, and treating pneumonia. Objective: ...

    • Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels 

      Triebner, Kai; Johannessen, Ane; Svanes, Cecilie; Leynaert, Bénédicte; Benediktsdóttir, Bryndís; Demoly, Pascal; Dharmage, Shyamali C.; Franklin, Karl A.; Heinrich, Joachim; Holm, Mathias; Jarvis, Deborah; Lindberg, Eva; Moratalla, Jesús Martínez; Agirre, Nerea Muniozguren; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Skulstad, Svein Magne; Hustad, Steinar; Rodríguez, Francisco J.; Gomez Real, Francisco (Journal article; Peer reviewed, 2020)
      Objective Most women live to experience menopause and will spend 4–8 years transitioning from fertile age to full menstrual stop. Biologically, reproductive ageing is a continuous process, but by convention, it is defined ...

    • Discovery of novel candidates for anti- liposarcoma therapies by medium-scale high-throughput drug screening 

      Grad, Iwona; Hanes, Robert; Ayuda-Durán, Pilar; Kuijjer, Marieke Lydia; Enserink, Jorrit; Meza-Zepeda, Leonardo A; Myklebost, Ola (Journal article; Peer reviewed, 2021)
      Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor mutation analysis has not led to significant treatment ...

    • Endothelial dysfunction in ME/CFS patients 

      Sandvik, Miriam Kristine; Sørland, Kari; Leirgul, Elisabeth; Rekeland, Ingrid Gurvin; Stavland, Christina Særsten; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2023-02-02)
      Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study investigated large-vessel and small-vessel endothelial ...

    • Factors associated with coronary heart disease in COPD patients and controls 

      Svendsen, Christina D.; Kuiper, Karel Kier-Jan; Ostridge, Kristoffer; Larsen, Terje Hjalmar; Nielsen, Rune; Hodneland, Vidar; Nordeide, Eli; Bakke, Per S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022-04-27)
      Background: COPD and coronary heart disease (CHD) frequently co-occur, yet which COPD phenotypes are most prone to CHD is poorly understood. The aim of this study was to see whether COPD patients did have a true higher ...

    • Fear of Covid 19 during the third wave of infection in Norwegian patients with type 1 diabetes 

      Ueland, Grethe Åstrøm; Ernes, Tony; Madsen, Tone Vonheim; Husebye, Eystein Sverre; Sandberg, Sverre; Løvaas, Karianne Fjeld; Cooper, John (Journal article; Peer reviewed, 2022)
      Objective To study the fear of Covid 19 infection among Norwegian patients with type 1 diabetes. Research design and methods Fear of Covid 19 scale, a validated scale assessing the fear of Covid 19, was sent electronically ...

    • Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort 

      Sigurðardóttir, Erla S.; Gislason, Thorarinn; Benediktsdottir, Bryndis; Hustad, Simon Steinar; Dadvand, Payam; Demoly, Pascal; Franklin, Karl A.; Heinrich, Joachim; Holm, Mathias; van der Plaat, Diana A.; Jõgi, Rain; Leynaert, Benedicte; Lindberg, Eva; Martinez-Moratalla, Jesus; De Aja, Leire Sainz; Pesce, Giancarlo; Pin, Isabelle; Raherison, Chantal; Pereira-Vega, Antonio; Real, Francisco Gomez; Triebner, Kai Philipp (Journal article; Peer reviewed, 2022)
      Background The prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based ...

    • How many days of continuous physical activity monitoring reliably represent time in different intensities in cancer survivors 

      Western, Benedikte; Demmelmaier, Ingrid; Vistad, Ingvild; Hansen, Bjørge Hermann; Stenling, Andreas; Henriksen, Hege; Nordin, Karin; Blomhoff, Rune; Berntsen, Sveinung (Journal article; Peer reviewed, 2023)
      Background Physical activity (PA) monitoring is applied in a growing number of studies within cancer research. However, no consensus exists on how many days PA should be monitored to obtain reliable estimates in the cancer ...

    • Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT) 

      Samuelsen, Per-Jostein; Eggen, Anne Elise; Steigen, Terje; Wilsgaard, Tom; Kristensen, Andreas; Skogsholm, Anne; Holme, Elizabeth; van den Heuvel, Christian; Nordrehaug, Jan Erik; Bendz, Bjørn; Nilsen, Dennis W.T.; Bønaa, Kaare Harald (Journal article; Peer reviewed, 2021)
      Introduction Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian ...

    • A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease 

      Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Wiker, Harald Gotten; Leiten, Elise Orvedal; Husebø, Gunnar Reksten; Knudsen, Kristel Svalland; Tangedal, Solveig; Sanseverino, Walter; Paytuví-Gallart, Andreu; Nielsen, Rune (Journal article; Peer reviewed, 2022-05-12)
      Background: Few studies have examined the stability of the pulmonary mycobiome. We report longitudinal changes in the oral and pulmonary mycobiome of participants with and without COPD in a large-scale bronchoscopy study ...

    • Low risk pregnancies after a cesarean section: Determinants of trial of labor and its failure 

      Lehmann, Sjur; Baghestan, Elham; Børdahl, Per E; Irgens, Lorentz M.; Rasmussen, Svein (Journal article; Peer reviewed, 2020-01-13)
      Introduction: In pregnancies after a previous cesarean section (CS), a planned repeat CS delivery has been associated with excess risk of adverse outcome. However, also the alternative, a trial of labor after CS (TOLAC), ...

    • Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study 

      Hanem, Liv Guro Engen; Salvesen, Øyvind; Madsen, Andre; Sagen, Jørn Vegard; Mellgren, Gunnar; Juliusson, Petur Benedikt; Carlsen, Sven Magnus; Vanky, Eszter; Ødegård, Rønnaug (Journal article; Peer reviewed, 2021)
      Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with potential effects on offspring both genetically and through altered intrauterine environment. Metformin, which ameliorate hormonal disturbances ...

    • Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study 

      Grindheim, Sindre; Ebbing, Cathrine; Karlsen, Henriette Odland; Skulstad, Svein Magne; Real, Francisco Gomez; Lønnebotn, Marianne; Løvvik, Tone Shetelig; Vanky, Eszter; Kessler, Jørg (Journal article; Peer reviewed, 2022-01-28)
      Background: Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are ...

    • The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer 

      Poduval, Deepak; Sichmanovà, Zuzana; Straume, Anne Hege; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2020)
      miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers. We analyzed small RNA ...

    • Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study 

      Knudsen, Gerd Toril Mørkve; Dharmage, Shyamali C.; Janson, Christer; Abramson, Michael J.; Benediktsdóttir, Bryndís; Malinovschi, Andrei; Skulstad, Svein Magne; Bertelsen, Randi Jacobsen; Real, Francisco Gomez; Schlünssen, Vivi; Jögi, Nils Oskar; Sánchez-Ramos, José Luis; Holm, Mathias; Garcia-Aymerich, Judith; Forsberg, Bertil; Svanes, Cecilie; Johannessen, Ane (Journal article; Peer reviewed, 2020)
      Emerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index ...

    • PIK3CA mutations and their impact on survival outcomes of patients with endometrial cancer: A systematic review and meta-analysis 

      Bredin, Hanna Kosberg; Krakstad, Camilla; Høivik, Erling André (Journal article; Peer reviewed, 2023-03-21)
      Several studies have highlighted the frequent alterations of the PI3K pathway in endometrial cancer leading to increased signaling activation with potential for targeted treatment. The objective of this meta-study was to ...

    • The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL 

      Lundåsen, Thomas; Pedrelli, Matteo; Bjørndal, Bodil; Rozell, Björn; Kuiper, Raoul; Burri, Lena; Pavanello, Chiara; Turri, Marta; Skorve, Jon; Berge, Rolf Kristian; Alexson, Stefan E.H.; Tillander, Veronika (Journal article; Peer reviewed, 2020)
      Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including ...