Blar i Department of Clinical Science på tidsskrift "PLoS ONE"
Viser treff 1-20 av 52
-
Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms
(Peer reviewed; Journal article, 2015-04-08)Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate ... -
The Active Tamoxifen Metabolite Endoxifen (4OHNDtam) Strongly Down-Regulates Cytokeratin 6 (CK6) in MCF-7 Breast Cancer Cells
(Peer reviewed; Journal article, 2015-04-13)Introduction: Tamoxifen is an anti-estrogen drug used in treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sumof tamoxifen and all itsmetabolites. 4-Hydroxytamoxifen ... -
Altered development of fetal liver perfusion in pregnancies with pregestational diabetes
(Peer reviewed; Journal article, 2019-03-13)Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal ... -
Assessment of malaria real-time PCR methods and application with focus on lowlevel parasitaemia
(Peer reviewed; Journal article, 2019-07-05)In epidemiological surveys and surveillance the application of molecular tools is essential in detecting submicroscopic malaria. A genus-specific conventional cytochrome b (cytb) PCR has shown high sensitivity in field ... -
The Association between Progression of Atherosclerosis and the Methylated Amino Acids Asymmetric Dimethylarginine and Trimethyllysine
(Peer reviewed; Journal article, 2013-05-29)Objective: We previously showed that treatment with folic acid (FA)/B12 was associated with more rapid progression of coronary artery disease (CAD). High doses of FA may induce methylation by increasing the availability ... -
Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European Cohorts
(Peer reviewed; Journal article, 2014-03-10)Background: Gene variants known to contribute to Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of the genetic component ... -
Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations
(Peer reviewed; Journal article, 2015-04-17)We analyzed for associations between a variable number of tandem repeat (VNTR) polymorphism in the Family with sequence similarity 46, member A (FAM46A) gene and a single nucleotide polymorphism (rs3117582) in the ... -
Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity
(Peer reviewed; Journal article, 2014-12-11)Background Co-infection with malaria and HIV increases the severity and mortality of both diseases, but the cytokine responses related to this co-infection are only partially characterised. The aim of this study was to ... -
Development of a bioluminescent nitroreductase probe for preclinical imaging
(Peer reviewed; Journal article, 2015-06-25)Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In ... -
Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
(Peer reviewed; Journal article, 2019)Background: The Discharge Care Experiences Survey (DICARES) was previously developed to measure quality of discharge care in elderly patients (≥ 65 years). The objective of this study was to test the factorial validity of ... -
Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy
(Peer reviewed; Journal article, 2017-11-16)Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not ... -
Early vascular aging in young and middle-aged ischemic stroke patients: The Norwegian stroke in the young study
(Peer reviewed; Journal article, 2014-11-18)Background: Ischemic stroke survivors have high risk of cardiovascular morbidity and mortality even at young age, suggesting that early arterial aging is common among such patients. Methods: We measured aortic stiffness ... -
Effect of Folic Acid Supplementation on Levels of Circulating Monocyte Chemoattractant Protein-1 and the Presence of Intravascular Ultrasound Derived Virtual Histology Thin-Cap Fibroatheromas in Patients with Stable Angina Pectoris
(Peer reviewed; Journal article, 2013-07-25)Background: Virtual Histology Intravascular Ultrasound (VH–IVUS) may be used to detect early signs of unstable coronary artery disease. Monocyte Chemoattractant Protein-1 (MCP-1) is linked with coronary atherosclerosis and ... -
Elderly patients’ (≥65 years) experiences associated with discharge; Development, validity and reliability of the Discharge Care Experiences Survey
(Peer reviewed; Journal article, 2018-11-07)Background: A review of the literature reveals a lack of validated instruments that particularly measure quality in the hospital discharge process. This study aims to develop and validate a survey instrument feasible for ... -
Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study
(Peer reviewed; Journal article, 2019-04-25)Background: Although electrolyte imbalances (EIs) are common in the emergency department (ED), few studies have examined the occurrence of such conditions in an unselected population. Objectives: To investigate the frequency ... -
Endometrial ablation; less is more? Historical cohort study comparing long-term outcomes from two time periods and two treatment modalities for 854 women
(Peer reviewed; Journal article, 2019-07-10)Background: Abnormal uterine bleeding needs surgical treatment if medical therapy fails. After introduction of non-hysteroscopic endometrial ablation as alternative to hysteroscopic endometrial resection, we aimed to compare ... -
Epidemiology and impact on all-cause mortality of sepsis in Norwegian hospitals: A national retrospective study
(Peer reviewed; Journal article, 2017-11-17)Background: Although sepsis is the leading cause of death from infection, there are few population-level epidemiological sepsis reports. The impact of sepsis-related deaths on all-cause hospital mortality is insufficiently ... -
Exposure to preeclampsia growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study
(Peer reviewed; Journal article, 2017-05-09)Background and objective An adverse intrauterine environment may affect offspring growth and development. Our aim was to explore whether preeclampsia (PE) exposure in utero influences growth from birth to 13 years. Methods ... -
First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma
(Peer reviewed; Journal article, 2014-03-04)Purpose: Preclinical models of epithelial ovarian cancer have not been exploited to evaluate the clinical standard combination therapy of surgical debulking with follow-up chemotherapy. As surgery is critical to patient ... -
The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy Indian adolescents
(Peer reviewed; Journal article, 2014-07-03)Background: QuantiFERON-TB Gold In-Tube (QFT) is an IFNγ-release assay used in the diagnosis of Mycobacterium tuberculosis (MTB) infection. The risk of TB progression increases with the magnitude of the MTB-specific ...