• Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort 

      Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Brattbakk, Hans-Richard; Steen, Vidar Martin; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2022)
      Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ...
    • Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Background Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation. ...