Blar i Department of Clinical Science på tittel

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    • UGT1A4 og UGT2B15 enkeltnukleotidpolymorfismer. Etablering av real time PCR metoder og betydning for tamoxifen metabolisme 

      Ness, Ole-Johan (Master thesis, 2008-06-02)
      Brystkreft er den vanligste kreftformen blant kvinner i Norge og adjuvant tamoxifenbehandling er vist å øke tilbakefallsfri og total overlevelse. Den interinidividuelle varaiasjonen i effekt og bivirkninger av tamoxifen ...

    • Ultraprosessert mat burde være et kostråd: JA 

      Dankel, Simon N; Molin, Marianne; Bere, Elling Tufte (Journal article, 2023)

    • Ultrasensitive Assays for Targeted Breast Cancer Treatment 

      Bertelsen, Bjørn-Erik (Doctoral thesis, 2025-01-23)
      Den avgjørende rollen til østrogen i østrogenreseptor-positiv (ER+) brystkreft er veletablert, hvor aromatasehemmere som hemmer østrogensyntesen er sentral i behandlingen av brystkreft. Imidlertid er kvantifiseringen av ...

    • An ultrasensitive routine LC-MS/MS method for estradiol and estrone in the clinically relevant sub-picomolar range 

      Bertelsen, Bjørn-Erik; Kellmann, Ralf; Viste, Kristin; Bjørnevik, Anne Turid; Eikesdal, Hans Petter; Lønning, Per Eystein; Sagen, Jørn V.; Almås, Bjørg (Journal article; Peer reviewed, 2020)
      Background Current analytical routine methods lack the sensitivity to monitor plasma estrogen levels in breast cancer patients treated with aromatase inhibitors. Such monitoring is warranted for premenopausal patients ...

    • Ultrasonography of major salivary glands in primary and juvenile Sjögren’s syndrome 

      Hammenfors, Daniel S. (Doctoral thesis, 2019-06-07)
      Background: Primary Sjögrens’s syndrome (pSS) is a systemic autoimmune disease, mainly affecting the salivary and lacrimal glands. Primary SS can also affect the younger population and when it does, the denomination is ...

    • Ultrasound in Crohn’s Disease - bowel wall characteristics and perfusion estimates using microbubbles 

      Nylund, Kim (Doctoral thesis, 2013-01-18)
      Crohn’s disease (CD) is a chronic inflammatory bowel disease which often presents early in life and sometimes can be debilitating. The patients need frequent diagnostic work-up to assess disease activity, location, extent ...

    • Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells 

      Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen; Kamceva, Tina; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Schjøtt, Jan; Riedel, Bettina; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles ...

    • Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS) 

      Triebner, Kai; Bifulco, Ersilia; Barrera-Gómez, Jose; Basagaña, Xavier; Benediktsdóttir, Bryndís; Forsberg, Bertil; Franklin, Karl A.; Garcia-Larsen, Vanessa; Leynaert, Bénédicte; Lindberg, Eva; Martínez-Moratalla, Jesús; Muniozguren-Agirre, Nerea; Pin, Isabelle; Raherison, Chantal; Pereira-Vega, Antonio; Schlünssen, Vivi; Valentin, Antonia; Hustad, Steinar; Real, Francisco Gomez; Dadvand, Payam (Journal article; Peer reviewed, 2021)
      Background Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites ...

    • Understanding fatigue in Sjögren’s Syndrome: Outcome measures, biomarkers and possible interventions 

      Mæland, Elisabeth; Miyamoto, Samira T.; Hammenfors, Daniel; Valim, Valeria; Jonsson, Malin Viktoria (Journal article; Peer reviewed, 2021)
      Sjögren’s syndrome (SS) is an autoimmune disease affecting the salivary and lacrimal glands. Symptoms range from dryness to severe extra-glandular disease involving manifestations in the skin, lungs, nervous system, and ...

    • Understanding the Effects of Antipsychotics on Appetite Control 

      Mukherjee, Sayani; Skrede, Silje; Milbank, Edward; Andriantsitohaina, Ramaroson; López, Miguel; Fernø, Johan (Journal article; Peer reviewed, 2021)
      Antipsychotic drugs (APDs) represent a cornerstone in the treatment of schizophrenia and other psychoses. The effectiveness of the first generation (typical) APDs are hampered by so-called extrapyramidal side effects, and ...

    • Understanding the genetic complexity of puberty timing across the allele frequency spectrum 

      Kentistou, Katherine A.; Kaisinger, Lena R.; Stankovic, Stasa; Vaudel, Marc; Mendes de Oliveira, Edson; Messina, Andrea; Walters, Robin G.; Liu, Xiaoxi; Busch, Alexander S.; Helgason, Hannes; Thompson, Deborah J.; Santoni, Federico; Petricek, Konstantin M.; Zouaghi, Yassine; Huang-Doran, Isabel; Gudbjartsson, Daniel F.; Bratland, Eirik; Lin, Kuang; Gardner, Eugene J.; Zhao, Yajie; Jia, Raina Y.; Terao, Chikashi; Riggan, Marjorie J.; Bolla, Manjeet K.; Yazdanpanah, Mojgan; Yazdanpanah, Nahid; Bradfield, Jonathan P.; Broer, Linda; Campbell, Archie; Chasman, Daniel I.; Cousminer, Diana L.; Franceschini, Nora; Franke, Lude H.; Girotto, Giorgia; He, Chunyan; Järvelin, Marjo-Riitta; Joshi, Peter K.; Kamatani, Yoichiro; Karlsson, Robert; Luan, Jian’an; Lunetta, Kathryn L.; Mägi, Reedik; Mangino, Massimo; Medland, Sarah E.; Meisinger, Christa; Noordam, Raymond; Nutile, Teresa; Concas, Maria Pina; Polašek, Ozren; Porcu, Eleonora; Ring, Susan M.; Sala, Cinzia; Smith, Albert V.; Tanaka, Toshiko; van der Most, Peter J.; Vitart, Veronique; Wang, Carol A.; Willemsen, Gonneke; Zygmunt, Marek; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antoniou, Antonis C.; Auer, Paul L.; Barnes, Catriona L. K.; Beckmann, Matthias W.; Berrington de Gonzalez, Amy; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Buring, Julie E.; Canzian, Federico; Chang-Claude, Jenny; Couch, Fergus J.; Cox, Angela; Crisponi, Laura; Czene, Kamila; Daly, Mary B.; Demerath, Ellen W.; Dennis, Joe; Devilee, Peter; De Vivo, Immaculata; Dörk, Thilo; Dunning, Alison M.; Dwek, Miriam; Eriksson, Johan G.; Fasching, Peter A.; Fernandez-Rhodes, Lindsay; Ferreli, Liana; Fletcher, Olivia; Gago-Dominguez, Manuela; García-Closas, Montserrat; García-Sáenz, José A.; González-Neira, Anna; Grallert, Harald; Guénel, Pascal; Haiman, Christopher A.; Hall, Per; Hamann, Ute; Hakonarson, Hakon; Hart, Roger J.; Hickey, Martha; Hooning, Maartje J.; Hoppe, Reiner; Hopper, John L.; Hottenga, Jouke-Jan; Hu, Frank B.; Huebner, Hanna; Hunter, David J.; Jernström, Helena; John, Esther M.; Karasik, David; Khusnutdinova, Elza K.; Kristensen, Vessela N.; Lacey, James V.; Lambrechts, Diether; Launer, Lenore J.; Lind, Penelope A.; Lindblom, Annika; Magnusson, Patrik K. E.; Mannermaa, Arto; McCarthy, Mark I.; Meitinger, Thomas; Menni, Cristina; Michailidou, Kyriaki; Millwood, Iona Y.; Milne, Roger L.; Montgomery, Grant W.; Nevanlinna, Heli; Nolte, Ilja M.; Nyholt, Dale R.; Obi, Nadia; O’Brien, Katie M.; Offit, Kenneth; Oldehinkel, Albertine J.; Ostrowski, Sisse R.; Palotie, Aarno; Pedersen, Ole B.; Peters, Annette; Pianigiani, Giulia; Plaseska-Karanfilska, Dijana; Pouta, Anneli; Pozarickij, Alfred; Radice, Paolo; Rennert, Gad; Rosendaal, Frits Richard; Ruggiero, Daniela; Saloustros, Emmanouil; Sandler, Dale P.; Schipf, Sabine; Schmidt, Carsten O.; Schmidt, Marjanka K.; Small, Kerrin; Spedicati, Beatrice; Stampfer, Meir; Stone, Jennifer; Tamimi, Rulla M.; Teras, Lauren R.; Tikkanen, Emmi; Turman, Constance; Vachon, Celine M.; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Zemel, Babette S.; Zheng, Wei; van Dijk, Ko W.; Alizadeh, Behrooz Z.; Bandinelli, Stefania; Boerwinkle, Eric; Boomsma, Dorret I.; Ciullo, Marina; Chenevix-Trench, Georgia; Cucca, Francesco; Esko, Tõnu; Gieger, Christian; Grant, Struan F. A.; Gudnason, Vilmundur; Hayward, Caroline; Kolčić, Ivana; Kraft, Peter; Lawlor, Deborah A.; Martin, Nicholas G.; Nøhr, Ellen Aagaard; Pedersen, Nancy L.; Pennell, Craig E.; Ridker, Paul M.; Robino, Antonietta; Snieder, Harold; Sovio, Ulla; Spector, Tim D.; Stöckl, Doris; Sudlow, Cathie; Timpson, Nic J.; Toniolo, Daniela; Uitterlinden, André; Ulivi, Sheila; Völzke, Henry; Wareham, Nicholas J.; Widen, Elisabeth; Wilson, James F.; Pharoah, Paul D. P.; Li, Liming; Easton, Douglas F.; Njølstad, Pål Rasmus; Sulem, Patrick; Murabito, Joanne M.; Murray, Anna; Manousaki, Despoina; Juul, Anders; Erikstrup, Christian; Stefansson, Kari; Horikoshi, Momoko; Chen, Zhengming; Farooqi, I. Sadaf; Pitteloud, Nelly; Johansson, Stefan; Day, Felix R.; Perry, John R. B.; Ong, Ken K.; John, Esther M.; Hall, Per; Winqvis, Robert (Journal article; Peer reviewed, 2024)
      Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained ...

    • Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center 

      Steiner, Sophie; Fehrer, Annick; Hoheisel, Friederike; Schoening, Simon; Aschenbrenner, Anna; Babel, Nina; Bellmann-Strobl, Judith; Finke, Carsten; Fluge, Øystein; Froehlich, Laura; Goebel, Andreas; Grande, Bettina; Haas, Johannes-Peter; Hohberger, Bettina; Jason, Leonard A.; Komaroff, Anthony L.; Lacerda, Eliana; Liebl, Max; Maier, Andrea; Mella, Olav; Nacul, Luis; Paul, Friedemann; Prusty, Bhupesh K.; Puta, Christian; Riemekasten, Gabriela; Ries, Wolfgang; Rowe, Peter C.; Sawitzki, Birgit; Shoenfeld, Yehuda; Schultze, Joachim L.; Seifert, Martina; Sepúlveda, Nuno; Sotzny, Franziska; Stein, Elisa; Stingl, Michael; Ufer, Friederike; Veauthier, Christian; Westermeier, Francisco; Wirth, Klaus; Wolfarth, Bernd; Zalewski, Pawel; Behrends, Uta; Scheibenbogen, Carmen (Journal article; Peer reviewed, 2023)
      Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase ...

    • Undersøke sammenhengen mellom jernstatus og jernabsorpsjon. Sammenligning av friske og pasienter med hemokromatose 

      Bø, Eirik Svandal (Master thesis, 2008-06-01)
      Jern er et essensielt spormetall som vi har ca 3-4 g av i kroppen. Jern inngår i flere proteiner, der hemoglobin er det viktigste. Jern er også delaktig i flere redoksreaksjoner i kroppen vår. Vi trenger daglig et tilskudd ...

    • Undersøkelse av formuleringstekniske aspekter for Krembase NAF og Krembase NAF som grunnlag i magistrell fremstilling 

      Skadberg, Ragnhild (Master thesis, 2024-06-03)
      Krembase NAF er et produkt med lang historie i norske apotek, men det er likevel begrenset informasjon tilgjengelig om de formuleringstekniske egenskapene. I denne oppgaven er derfor formuleringens robusthet undersøkt, og ...

    • Unexplained chronic liver disease in Ethiopia: a cross-sectional study 

      Orlien, Stian Magnus Staurung; Ismael, Nejib Yusuf; Ahmed, Tekabe Abdosh; Berhe, Nega; Lauritzen, Trine; Roald, Borghild; Goldin, Robert David; Stene-Johansen, Kathrine; Dyrhol-Riise, Anne Ma; Gundersen, Svein Gunnar; Morgan, Marsha Yvonne; Johannessen, Asgeir (Peer reviewed; Journal article, 2018-02-13)
      Background: Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution of other aetiological causes of CLD is less well documented and hence ...

    • Unexplained, self-reported food hypersensitivity. Explorative studies on mechanisms of abdominal symptom generation 

      Valeur, Jørgen (Doctoral thesis, 2010-10-08)
      Background: Self-reported food hypersensitivity remains unexplained in most cases. Abdominal symptoms, typically consistent with the irritable bowel syndrome (IBS), are common in patients with such unexplained, self-reported ...

    • Unperturbed cytotoxic lymphocyte phenotype and function in myalgic encephalomyelitis/chronic fatigue syndrome patients 

      Theorell, Jakob; Bileviciute-Ljungar, Indre; Tesi, Bianca; Schlums, Heinrich; Johnsgaard, Mette Sophie; Asadi-Azarbaijani, Babak; Strand, Elin Bolle; Bryceson, Yenan (Peer reviewed; Journal article, 2017-06-26)
      Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular infections as well as physiological stress. Cytotoxic lymphocytes combat intracellular infections. ...

    • Unraveling the shared genetics of common epilepsies and general cognitive ability 

      Karadag, Naz; Hagen, Espen; Shadrin, Alexey; van der Meer, Dennis; O'Connell, Kevin Sean; Rahman, Mohammad Zillur; Kutrolli, Gleda; Parker, Nadine; Bahrami, Shahram; Fominykh, Vera; Heuser, Kjell; Taubøll, Erik; Ueland, Torill; Steen, Nils Eiel; Djurovic, Srdjan; Dale, Anders M; Frei, Oleksandr; Andreassen, Ole A.; Smeland, Olav Bjerkehagen (Journal article; Peer reviewed, 2024)
      Purpose Cognitive impairment is prevalent among individuals with epilepsy, and increasing evidence indicates that genetic factors can underlie this relationship. However, the extent to which epilepsy subtypes differ in ...

    • Unravelling influenza correlates of protection: lessons from human A/H1N1 Challenge 

      Cox, Rebecca Jane; Pathirana, Rishi Delan (Journal article; Peer reviewed, 2024)
      Mucosal immunity is important in protecting from upper respiratory tract influenza infection. Human challenge provides a unique model to define correlates of protection with baseline immune responses being correlated to ...

    • Unsupervised clustering of missense variants in HNF1A using multidimensional functional data aids clinical interpretation 

      Althari, Sara; Najmi, Laeya Abdoli; Bennett, Amanda J.; Aukrust, Ingvild; Rundle, Jana K.; Colclough, Kevin; Molnes, Janne; Kaci, Alba; Nawaz, Sameena; van der Lugt, Timme; Hassanali, Neelam; Mahajan, Anubha; Molven, Anders; Ellard, Sian; McCarthy, Mark I.; Bjørkhaug, Lise; Njølstad, Pål Rasmus; Gloyn, Anna L. (Journal article; Peer reviewed, 2020-10-01)
      Exome sequencing in diabetes presents a diagnostic challenge because depending on frequency, functional impact, and genomic and environmental contexts, HNF1A variants can cause maturity-onset diabetes of the young (MODY), ...