Blar i Department of Clinical Science på tittel

Viser treff 1075-1094 av 2294

    • Impact of aortic stiffness on myocardial ischaemia in non-obstructive coronary artery disease 

      Lønnebakken, Mai Tone; Eskerud, Ingeborg; Larsen, Terje H; Midtbø, Helga Bergljot; Kokorina, Marina Victorovna; Gerdts, Eva (Peer reviewed; Journal article, 2019)
      Objective: High aortic stiffness may reduce myocardial perfusion pressure and contribute to development of myocardial ischaemia. Whether high aortic stiffness is associated with myocardial ischaemia in patients with stable ...

    • Impact of aortic valve stenosis on myocardial deformation in different left ventricular levels: A three-dimensional speckle tracking echocardiography study 

      Hjertaas, Johannes Just; Einarsen, Eigir; Gerdts, Eva; Kokorina, Marina Victorovna; Moen, Christian Arvei; Urheim, Stig; Saeed, Sahrai; Matre, Knut (Journal article; Peer reviewed, 2023)
      Background: Global systolic left ventricular (LV) myocardial function progressively declines as degenerative aortic valve stenosis (AS) progresses. Whether this results in uniformly distributed deformation changes from ...

    • Impact of arterio–ventricular interaction on first-phase ejection fraction in aortic stenosis 

      Einarsen, Eigir; Hjertaas, Johannes Just; Gu, Haotian; Matre, Knut; Chowienczyk, Philip J.; Gerdts, Eva; Chambers, John B.; Saeed, Sahrai (Peer reviewed; Journal article, 2020)
      Aims:  First-phase ejection fraction (EF1), the EF at the time to peak aortic jet velocity, has been proposed as a novel marker of peak systolic function in aortic stenosis (AS). This study aimed to explore the association ...

    • Impact of different preanalytical conditions on results of lupus anticoagulant tests 

      Kristoffersen, Ann-Helen; Jansrud, Ida; Vannes, Solveig; Åsberg, Arne; Aakre, Kristin Moberg (Peer reviewed; Journal article, 2019)
      Introduction: The currently recommended preanalytical conditions for lupus anticoagulant (LA) analysis require analyzing samples in fresh or freshly frozen platelet‐poor plasma. The aim of this study was to evaluate whether ...

    • Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction 

      Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam; Trøseid, Marius (Peer reviewed; Journal article, 2018-04-30)
      HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition ...

    • Impact of hormonal biomarkers on response to hormonal therapy in advanced and recurrent endometrial cancer 

      van Weelden, Willem Jan; Lalisang, Roy I; Bulten, Johan; Lindemann, Kristina Yvonne Kathe; van Beekhuizen, Heleen J.; Trum, Hans; Boll, Dorry; Werner, Henrica Maria Johanna; Lonkhuijzen, Luc R C W van; Yigit, Refika; Forsse, David; Witteveen, Petronella O; Galaal, Khadra; van Ginkel, Alexandra; Bignotti, Eliana; Weinberger, Vit; Sweegers, Sanne; Kroep, Judith R.; Cabrera, Silvia; Snijders, Marc P.L.M.; Inda, Márcia A; Eriksson, Ane Gerda Zahl; Krakstad, Camilla; Romano, Andrea; Stolpe, Anja van de; Pijnenborg, Johanna M.A. (Journal article; Peer reviewed, 2021)
      Background Approximately 20% of women with endometrial cancer have advanced-stage disease or suffer from a recurrence. For these women, prognosis is poor, and palliative treatment options include hormonal therapy and ...

    • Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3 

      Rembeck, Karolina; Alsiö, Åsa; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Westin, Johan; Lindh, Magnus; Hellstrand, Kristoffer; Norkrans, Gunnar; Lagging, Martin (Peer reviewed; Journal article, 2012-01-13)
      Background and Aims: Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome ...

    • Impact of Inititing Biologics in Patients With Severe Asthma on Long-term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry 

      Chen, Wenjia; Tran, Trung N.; Sadatsafavi, Mohsen; Murray, Ruth; Wong, Nigel Chong Boon; Ali, Nasloon; Ariti, Con; Bulathsinhala, Lakmini; Gil, Esther Garcia; FitzGerald, J. Mark; Alacqua, Marianna; Al-Ahmad, Mona; Altraja, Alan; Al-Lehebi, Riyad; Bhutani, Mohit; Bjermer, Leif Hilding; Bjerrum, Anne-Sofie; Bourdin, Arnaud; von Bülow, Anna; Busby, John; Canonica, Giorgio Walter; Carter, Victoria; Christoff, George C.; Cosio, Borja G.; Costello, Richard W.; Fonseca, João A.; Gibson, Peter G.; Yoo, Kwang-Ha; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Iwanaga, Takashi; Jackson, David J.; Jones, Rupert C.; Koh, Mariko Siyue; Kuna, Piotr; Larenas-Linnemann, Désirée; Lehmann, Sverre; Lehtimäki, Lauri; Lyu, Juntao; Mahboub, Bassam; Maspero, Jorge; Menzies-Gow, Andrew N.; Newell, Anthony; Sirena, Concetta; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Perez-de-Llano, Luis; Perng (Steve), Diahn-Warng; Peters, Matthew; Pfeffer, Paul E.; Porsbjerg, Celeste M.; Popov, Todor A.; Rhee, Chin Kook; Salvi, Sundeep; Taillé, Camille; Taube, Christian; Torres-Duque, Carlos A.; Ulrik, Charlotte; Ra, Seung-Won; Wang, Eileen; Wechsler, Michael E.; Price, David B. (Journal article; Peer reviewed, 2023)
      Background Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective To examine ...

    • Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients 

      Larsen, Stein Gunnar; Goscinski, Mariusz Adam; Dueland, Svein; Steigen, Sonja Eriksson; Hofsli, Eva; Torgunrud, A.; Lund-Iversen, Marius; Dagenborg, Vegar Johansen; Flatmark, Kjersti; Sorbye, Halfdan (Journal article; Peer reviewed, 2021)
      Background Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal ...

    • Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases 

      Løes, Inger Marie; Immervoll, Heike; Sorbye, Halfdan; Angelsen, Jon-Helge; Horn, Arild; Knappskog, Stian; Lønning, Per Eystein (Peer reviewed; Journal article, 2016-04)
      We determined prognostic impact of KRAS, BRAF, PIK3CA and TP53 mutation status and mutation heterogeneity among 164 colorectal cancer (CRC) patients undergoing liver resections for metastatic disease. Mutation status was ...

    • Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer 

      Helwa, Reham; Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Dørum, Anne; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2021)
      Background While large GWAS analyses have not found convincing associations between MDM2 promoter SNP55 and gynaecological cancers, SNP55 is in linkage disequilibrium with two other functional SNPs in the same promoter, ...

    • Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Ponikowski, Piotr; Ravera, Alice; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2021)
      Aims Few data regarding the prevalence and prognostic impact of mitral regurgitation (MR) in patients with worsening chronic or new-onset acute heart failure (HF) are available. We investigated the role of MR in the BIOlogy ...

    • Impact of Obesity on the Bioavailability of Peginterferon-α2a and Ribavirin and Treatment Outcome for Chronic Hepatitis C Genotype 2 or 3 

      Alsiö, Åsa; Rembeck, Karolina; Askarieh, Galia; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Mørch, Kristine (Peer reviewed; Journal article, 2012-05-24)
      Background and Aims: Having a body mass index above or equal to 30 kg/m2 in conjunction with chronic hepatitis C virus infection is associated with non-responsiveness to treatment with interferon and ribavirin, but details ...

    • Impact of overweight on glucose homeostasis in MODY2 and MODY3 

      Romuld, Ingunn Bratland; Kalleklev, Tine-Lise; Molnes, Janne; Juliusson, Pétur Benedikt; Njølstad, Pål Rasmus; Sagen, Jørn Vegard (Journal article; Peer reviewed, 2021)

    • The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development 

      Wortinger, Laura Anne; Shadrin, Alexey; Szabo, Attila; Nerland, Stener; Smelror, Runar; Jørgensen, Kjetil Nordbø; Barth, Claudia; Andreou, Dimitrios; Thoresen, Marianne; Andreassen, Ole; Djurovic, Srdjan; Ursini, Gianluca; Agartz, Ingrid (Journal article; Peer reviewed, 2023)
      The placenta plays a role in fetal brain development, and pregnancy and birth complications can be signs of placental dysfunction. Birth asphyxia is associated with smaller head size and higher risk of developing schizophrenia ...

    • Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study 

      Monsen, Anne Lise Bjørke; Ulvik, Arve; Nilsen, Roy Miodini; Midttun, Øivind; Roth, Christine; Magnus, Per; Stoltenberg, Camilla; Vollset, Stein Emil; Reichborn-Kjennerud, Ted; Ueland, Per Magne (Peer reviewed; Journal article, 2016-11-30)
      Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, ...

    • Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR) 

      Serigstad, Sondre; Ritz, Christian; Faurholt-Jepsen, Daniel; Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Kommedal, Øyvind; Bjørneklett, Rune Oskar; Heggelund, Lars; Clark, Tristan W.; van Werkhoven, Cornelis H.; Knoop, Siri Tandberg; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2022)
      Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ...

    • Impact of the APOBEC3A/B deletion polymorphism on risk of ovarian cancer 

      Gansmo, Liv Beathe; Sofiyeva, Nigar; Bjørnslett, Merete Pauline; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Dørum, Anne; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2021)
      A germline 29.5-kb deletion variant removes the 3’ end of the APOBEC3A gene and a large part of APOBEC3B, creating a hybrid gene that has been linked to increased APOBEC3 activity and DNA damage in human cancers. We genotyped ...

    • Impact of the left ventricular lead on the efficacy of Cardiac Resynchronization Therapy for heart failure. : Electrophysiologic and clinical trials investigating active fixation left ventricular lead in cardiac resynchronization therapy. 

      Keilegavlen, Håvard (Doctoral thesis, 2021-04-09)
      Background: This thesis examines the performance of different left ventricular (LV) leads and in particular a novel bipolar LV lead with a side helix for active fixation. Cardiac resynchronization therapy (CRT) provides ...

    • Impact of the WHO Surgical Safety Checklist implementation on perioperative work and risk perceptions : A process evaluation by use of quantitative and qualitative methods 

      Wæhle, Hilde Valen (Doctoral thesis, 2020-02-14)
      Background: Human performance deficiencies account for a large proportion of adverse surgical events. The World Health Organization (WHO) Surgical Safety Checklist (SSC) was launched to improve teamwork and patient outcome. ...