Browsing Department of Clinical Science by Title
Now showing items 1307-1326 of 2438
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Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes
(Journal article; Peer reviewed, 2022)Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice ... -
Joint medicine-information and pharmacovigilance services could improve detection and communication about drug-safety problems
(Peer reviewed; Journal article, 2014-07-01)Background: RELIS is a Norwegian network of four regional medicine-information and pharmacovigilance centers where pharmacists and clinical pharmacologists provide feedback to health care professionals in spontaneous ... -
Kartlegging av holdninger til og bruk av urtemedisin i svangerskapet - En intervjuundersøkelse blant 142 barselkvinner ved Haukeland Universitetssjukehus
(Master thesis, 2009-09-18)Bakgrunn: Mange kvinner opplever en eller flere plager under graviditet. Få konvensjonelle legemidler er godkjente til bruk i svangerskapet, og flere vestlige studier rapporterer at en stor andel av gravide kvinner bruker ... -
Kartlegging av potensielt uhensiktsmessig legemiddelbruk hos eldre i Nordfjord ved bruk av STOPP-kriteriene
(Master thesis, 2014-05-20)Background: The biggest challenge facing health care in medication management and - treatment of the elderly is the combination of many diseases and use of many drugs. The patient safety campaign "In safe hands" is carried ... -
Kartlegging og analyse av henvendelser til sykehusapotek
(Master thesis, 2021-05-20)Bakgrunn: Sykehusapotek besitter viktig kompetanse som sikrer legemiddelforsyning til sykehus og enkeltpasienter, spesialproduserte legemidler som ikke kan skaffes fra industrien og faglige råd som bidrar til riktig ... -
Kidney complications and hospitalization in patients with chronic hypoparathyroidism: A cohort study in Sweden
(Journal article; Peer reviewed, 2022)Context: Kidney complications may be considerably higher in patients with chronic hypoparathyroidism (hypoPT) treated with activated vitamin D and calcium supplementation. Objective: We aimed to investigate the risk of ... -
Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial
(Journal article; Peer reviewed, 2022)Introduction Short term hypothermia has been suggested to have cardio protective properties in acute myocardial infarction (AMI) by reducing infarct size as assessed by troponins. There are limited data on the kinetics ... -
Kjernereseptorar og endokrinforstyrrande stoff: Ligandaktiveringsstudiar av human Pregnan X Reseptor (hPXR) og human Østrogen Reseptor alfa (hERalfa) med luciferase transfeksjonsassay
(Master thesis, 2008-05-28)Samandrag Pregnan X Reseptor (PXR) er ein kjernereseptor som ved aktivering kan indusere transkripsjon av CYP3A4 enzym. Desse enzyma er involvert i metabolisme av mange sambindingar som til dømes legemiddel. PXR vert ... -
Kosthold og fysisk aktivitet, har det en påvirkning på overvekt og fedme hos barn og unge? - En analyse av innsamlede data, og et systematisk litteratur søk
(Master thesis, 2012-05-15)Background: The prevalence of overweight and obesity has increased during the last decades in many countries, and current prevalence data are alarming and give reason for serious health concerns in the future. However, our ... -
KRAS-G12C mutation in one real-life and three population-based Nordic cohorts of metastatic colorectal cancer
(Journal article; Peer reviewed, 2022-02-16)Background: KRAS mutations, present in over 40% of metastatic colorectal cancer (mCRC), are negative predictive factors for anti-EGFR therapy. Mutations in KRAS-G12C have a cysteine residue for which drugs have been ... -
Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
(Peer reviewed; Journal article, 2011-12-29)Background: In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids (PUFA) has been shown to improve cardiac function in HF ... -
Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study
(Peer reviewed; Journal article, 2015-12-15)Background: Lipid abnormalities, enhanced inflammation and oxidative stress seem to represent a vicious circle in atherogenesis, and therapeutic options directed against these processes seems like a reasonable approach in ... -
Kronisk transplantat-mot-vertsykdom
(Journal article; Peer reviewed, 2023)Kronisk transplantat-mot-vert-sykdom er en senkomplikasjon etter allogen stamcelletransplantasjon, og medfører kronisk inflammasjon og fibrose i forskjellige organer på grunn av feil regulering av donors immunceller. ... -
Kvalitet av generika
(Master thesis, 2014-05-20)Bakgrunn: Forskning har vist at det er betydelig skepsis i befolkningen til generiske legemidler, selv om disse per definisjon er bioekvivalente. Dette har også blitt vist i flere bioekvivalensstudier. Det rapporteres ... -
The kynurenine pathway in cognition, dementia, and aging
(Doctoral thesis, 2021-06-16)Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling ... -
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics
(Journal article; Peer reviewed, 2021)Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This ... -
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
(Journal article; Peer reviewed, 2022)The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ... -
Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia
(Journal article; Peer reviewed, 2019)Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ... -
Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation
(Journal article; Peer reviewed, 2021)Background The opportunistic pathogens Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative bacteria associated with oral biofilm and periodontal disease. This study investigated interactions between F. ... -
Laboratory contamination in airway microbiome studies
(Peer reviewed; Journal article, 2019-08-14)Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ...