Blar i Department of Clinical Science på tittel
Viser treff 1354-1373 av 2574
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Intimal Hyperplasia. Experimental and Clinical Studies
(Doctoral thesis, 2014-10-27)Introduction: Intimal hyperplasia (IH) is recognized as the primary cause of reocclusion 2-24 months following vascular intervention and surgery, reportedly occurring in 30-50% of patients. It is an exaggerated form of the ... -
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines
(Journal article; Peer reviewed, 2020)Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We ... -
Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells
(Peer reviewed; Journal article, 2019-07-06)Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption ... -
Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge
(Peer reviewed; Journal article, 2014-05-21)We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret ... -
Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge
(Peer reviewed; Journal article, 2015-05)Highly pathogenic avian influenza H5N1 infection remains a public health threat and vaccination is the best measure of limiting the impact of a potential pandemic. Mucosal vaccines have the advantage of eliciting immune ... -
Intrauterine and genetic risk factors for proliferative diabetic retinopathy
(Doctoral thesis, 2022-05-13)Diabetes is a complex progressive metabolic disorder characterized by hyperglycemia and caused by different etiopathogenic factors. Individuals with diabetes have heterogeneous clinical representation and increased risk ... -
The intronic BRCA1 c.5407-25T>A variant causing partly skipping of exon 23—a likely pathogenic variant with reduced penetrance?
(Peer reviewed; Journal article, 2020-03-20)Rare sequence variants in the non-coding part of the BRCA genes are often reported as variants of uncertain significance (VUS), which leave patients and doctors in a challenging position. The aim of this study was to ... -
Investigating the gene expression and secretion of VCAM-1 and E-Selectin by brain endothelial cells in response to Porphyromonas gingivalis infection
(Master thesis, 2024-10-31)Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobic bacterium, is a key periodontal pathogen. It is not only linked to periodontal diseases (PD), but also to systemic inflammatory conditions – including ... -
Investigating the human jejunal microbiota
(Journal article; Peer reviewed, 2022)Descriptions of the small intestinal microbiota are deficient and conflicting. We aimed to get a reliable description of the jejunal bacterial microbiota by investigating samples from two separate jejunal segments collected ... -
Investigating the human small intestinal microbiota : Microbiological characterization of jejunal and ileal samples collected during surgery
(Doctoral thesis, 2022-10-25)Kartlegging av tynntarmsmikrobiota hos mennesker : Mikrobiologisk beskrivelse av kirurgiske prøver fra jejunum og ileum Beskrivelser av tynntarmsmikrobiota (tarmflora) i lærebøker og vitenskapelige artikler er lite ... -
Investigating the rationale for COPD maintenance therapy prescription across Europe, findings from a multi-country study
(Journal article; Peer reviewed, 2023)This study aims to understand healthcare professionals’ thoughts and motivations about optimal management and treatment of patients with chronic obstructive pulmonary disease (COPD). We conducted a DELPHI survey through ... -
Investigating the use of patient involvement and patient experience in quality improvement in Norway: rhetoric or reality?
(Peer reviewed; Journal article, 2013-06-06)Background: Patient involvement in health care decision making is part of a wider trend towards a more bottomup approach to service planning and provision, and patient experience is increasingly conceptualized as a core ... -
Investigation of complement component C4 copy number variation in human longevity
(Peer reviewed; Journal article, 2014-01-22)Genetic factors have been estimated to account for about 25% of the variation in an adult’s life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences ... -
Investigation of immune cells in psoriasis patients treated with infliximab
(Master thesis, 2021-05-20)Psoriasis is a chronic inflammatory disease that manifests in the skin affecting both sexes equally and all ages. In Norway, the prevalence reaches 11.43% in adults. Both genetics and environment factors are important in ... -
Investigation of perioperative work processes in provision of antibiotic prophylaxis: a prospective descriptive qualitative study across surgical specialties in Norway
(Peer reviewed; Journal article, 2019)Abstract Objective: Surgical site infections are known postoperative complications, yet the most preventable of healthcare-associated infections. Correct provision of surgical antibiotic prophylaxis (SAP) is crucial. Use ... -
Iodine status and thyroid function in a group of seaweed consumers in Norway
(Journal article; Peer reviewed, 2020)Seaweeds, or macroalgae, may be a good dietary iodine source but also a source of excessive iodine intake. The main aim in this study was to describe the iodine status and thyroid function in a group of macroalgae consumers. ... -
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
(Peer reviewed; Journal article, 2015-04)Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ... -
Ipilimumab in a real-world population: A prospective Phase IV trial with long-term follow-up
(Journal article; Peer reviewed, 2022)Ipilimumab was the first treatment that improved survival in advanced melanoma. Efficacy and toxicity in a real-world setting may differ from clinical trials, due to more liberal eligibility criteria and less intensive ... -
Iron Status in Norwegian Blood Donors
(Doctoral thesis, 2010-05-07)Background and aims: Blood banks in Norway struggle to close the gap between need and supply of blood. The overall objective of this study was to investigate the iron status in blood donors. The aims of this thesis were ... -
Irritable Bowel Syndrome and Chronic Fatigue 6 Years After Giardia Infection: A Controlled Prospective Cohort Study
(Peer reviewed; Journal article, 2014-08-12)Background. Functional gastrointestinal disorders and fatigue may follow acute infections. This study aimed to estimate the persistence, prevalence, and risk of irritable bowel syndrome and chronic fatigue 6 years after ...