Browsing Department of Clinical Science by Title
Now showing items 1417-1436 of 2397
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Maternal and iatrogenic factors influencing the duration of labour
(Doctoral thesis, 2023-06-22)Bakgrunn: Forlengede fødselsforløp er den fremste grunnen til keisersnitt og operative vaginale forløsninger på verdensbasis. Imidlertid er definisjonen av normal fødselsprogresjon og varighet gjenstand for en pågående ... -
Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring
(Journal article; Peer reviewed, 2021)Background: Studies investigating the effects of prenatal alcohol exposure on childhood attention-deficit hyperactivity disorder (ADHD) symptoms using conventional observational designs have reported inconsistent findings, ... -
Maternal diabetes mellitus and fetal venous liver flow – a longitudinal study
(Doctoral thesis, 2019-06-13)Background: Despite adequate glycemic control, the risks of perinatal complications and fetal macrosomia are increased in pregnancies with pregestational diabetes (PGDM). Maternal overweight, obesity and excess gestational ... -
Maternal influence on fetal size and use of longitudinal fetal surveillance in predicting adverse perinatal outcomes
(Doctoral thesis, 2016-06-15)Background: Fetal growth is influenced by maternal factors, but also more specifically determined by level of fetoplacental circulation. We tested the hypothesis that fetal abdominal circumference (AC) in the second trimester ... -
Maternal microchimerism in cord blood and risk of childhood-onset type 1 diabetes
(Peer reviewed; Journal article, 2019-09)Background: Maternal microchimerism (MMc), the transmission of small quantities of maternal cells to the fetus, is relatively common and persistent. MMc has been detected with increased frequency in the circulation and ... -
Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study
(Journal article; Peer reviewed, 2021)Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with potential effects on offspring both genetically and through altered intrauterine environment. Metformin, which ameliorate hormonal disturbances ... -
Maternal physical activity affects yolk sac size and growth in early pregnancy, but girls and boys use different strategies
(Journal article; Peer reviewed, 2023)This longitudinal study investigated the impact of actigraphy-measured maternal physical activity on yolk sac size during early development. The yolk sac, a transient extraembryonic organ, plays a crucial role in embryonic ... -
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
(Peer reviewed; Journal article, 2016-11-25)Background: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend ... -
Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection
(Journal article; Peer reviewed, 2021)The highly pathogenic avian influenza H5N1 viruses constantly evolve and give rise to novel variants that have caused widespread zoonotic outbreaks and sporadic human infections. Therefore, vaccines capable of eliciting ... -
Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets
(Peer reviewed; Journal article, 2015-07-06)Background and Methods: Highly pathogenic avian influenza (HPAI) viruses constitute a pandemic threat and the development of effective vaccines is a global priority. Sixty adults were recruited into a randomized clinical ... -
MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
(Peer reviewed; Journal article, 2017-02-03)Background: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with ... -
MDM2 Promoter SNP344T>A (rs1196333) Status Does Not Affect Cancer Risk
(Peer reviewed; Journal article, 2012-04-30)The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been ... -
MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer
(Peer reviewed; Journal article, 2016-09-14)Two functional SNPs (SNP285G > C; rs117039649 and SNP309T > G; rs2279744) have previously been reported to modulate Sp1 transcription factor binding to the promoter of the proto-oncogene MDM2, and to influence cancer risk. ... -
MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung- and prostate cancer risk.
(Peer reviewed; Journal article, 2015-10-16)The MDM4 protein plays an important part in the negative regulation of the tumor suppressor p53 through its interaction with MDM2. In line with this, MDM4 amplification has been observed in several tumor forms. A polymorphism ... -
Meal patterns associated with energy intake in people with obesity
(Journal article; Peer reviewed, 2022)It is widely assumed that people with obesity have several common eating patterns, including breakfast-skipping (1), eating during the night (2) and high fast-food consumption (3). However, differences in individual meal ... -
Measurement of left ventricular deformation using 3D echocardiography
(Doctoral thesis, 2023-06-05)Bakgrunn: 3D speckle tracking ekkokardiografi (STE) er en hjerteultralydmetode som gir mulighet for måling av deformasjonsparametere, som strain, rotasjon, tvist og torsjon. Den største begrensningen for 3D STE er lav tids- ... -
Measures of symmetry in gait. Methodological principles and clinical choices
(Doctoral thesis, 2012-02-24)The aim of this thesis is to evaluate measures of gait symmetry in subjects with disease or injury related to one-sided affection. This thesis also aims to relate objective measures of gait quality (gait symmetry) to other ... -
Measuring discharge care quality in hospitalised elderly: Development and validation of an instrument based on patients’ experiences
(Doctoral thesis, 2020-03-20)Background: Elderly patients account for a majority of hospital admissions. Their wellbeing and safety are at risk in the discharge process due to quality deficiencies, thus, accurate and vigorous instruments to monitor ... -
Measuring discharge quality based on elderly patients’ experiences with discharge conversation: a cross-sectional study
(Peer reviewed; Journal article, 2019)Background: Discharge conversation is an essential part of preparing patients for the period after hospitalisation. Successful communication during such conversations is associated with improved health outcomes for patients. ... -
Mechanical assist in cardiac arrest: Optimising circulatory support. Experimental studies.
(Doctoral thesis, 2022-03-30)Introduction: Mechanical circulatory support (MCS) may be useful in cardiac arrest (CA), both in- and out- of hospital. However, efficacy and survival benefit has been difficult to evaluate compared to standard cardiopulmonary ...