Browsing Department of Clinical Science by Title
Now showing items 1548-1567 of 2397
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Neuroinflammation Associated With Inborn Errors of Immunity
(Journal article; Peer reviewed, 2022)The advent of high-throughput sequencing has facilitated genotype-phenotype correlations in congenital diseases. This has provided molecular diagnosis and benefited patient management but has also revealed substantial ... -
Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes
(Journal article; Peer reviewed, 2022-05-05)Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ... -
Neuropsychiatric symptoms in dementia: long-term course and neuropathology
(Doctoral thesis, 2019-06-14)Aim: Neuropsychiatric symptoms (NPS) such as anxiety, apathy, and psychosis are important manifestations of dementia that have a major impact on the patient’s quality of life, carer burden, and risk of institutionalisation. ... -
The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance
(Journal article; Peer reviewed, 2022)Obesity, insulin resistance and type 2 diabetes represent major global health challenges, and a better mechanistic understanding of the altered metabolism in these conditions may give improved treatment strategies. SLC7A10, ... -
The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
(Peer reviewed; Journal article, 2014-10-04)Background: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ... -
The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
(Peer reviewed; Journal article, 2014-10-04)Background. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ... -
Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
(Journal article; Peer reviewed, 2023)Background Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information ... -
Neutrophil-to-lymphocyte ratio and outcomes in patients with new-onset or worsening heart failure with reduced and preserved ejection fraction
(Journal article; Peer reviewed, 2021)Aims Inflammation is thought to play a role in heart failure (HF) pathophysiology. Neutrophil-to-lymphocyte ratio (NLR) is a simple, routinely available measure of inflammation. Its relationship with other inflammatory ... -
New biomarkers in patients with chronic kidney disease, after kidney transplantation, in kidney donors and in acute myocardial infarction
(Doctoral thesis, 2024-01-12)Nye markører på nyreskade hos nyretransplanterte, nyre donorer, hos pasienter med nyresvikt og hos pasienter med akutt hjerteinfarkt Bakgrunn: Kronisk nyresvikt affiserer mange mennesker. Både insidens og prevalens ... -
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation
(Journal article; Peer reviewed, 2020)Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ... -
New Evidence About Aortic Valve Stenosis and Cardiovascular Hemodynamics
(Journal article; Peer reviewed, 2022)Aortic stenosis (AS) is the most common degenerative valvular disease in western word. In patients with severe AS, small changes in aortic valve area can lead to large changes in hemodynamics. The correct understanding of ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
(Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
New procedures for genetic testing and counselling of patients with breast or ovarian cancer
(Doctoral thesis, 2020-05-29)The aim of this PhD project was to evaluate alternative procedures for genetic testing and counselling of patients newly diagnosed with breast or ovarian cancer, in order to meet the expected increasing need of this health ... -
A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae
(Journal article; Peer reviewed, 2022)Acute myeloid leukemia and myelodysplastic syndromes are cancers of the bone marrow with poor prognosis in frail and older patients. To investigate cancer pathophysiology and therapies, confocal imaging of fluorescent ... -
New therapeutic targets in human acute myeloid leukemia
(Doctoral thesis, 2012-03-16) -
Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2013-11-06)Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was ... -
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
(Journal article; Peer reviewed, 2020)Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation and insulin ... -
NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity
(Peer reviewed; Journal article, 2019-07-16)Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ... -
No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts
(Journal article; Peer reviewed, 2024)Aims/hypothesis The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children. Methods The Danish ... -
No asymptomatic malaria parasitaemia found among 108 young children at one health facility in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2013-11-14)Background: Asymptomatic malaria parasitaemia has been reported in areas with high malaria transmission. It may serve as a reservoir for continued transmission, and furthermore complicates diagnostics, as not all individuals ...