Blar i Department of Clinical Science på tittel
Viser treff 1563-1582 av 2502
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Multi-omics and machine learning for the prevention and management of female reproductive health
(Journal article; Peer reviewed, 2023)Females typically carry most of the burden of reproduction in mammals. In humans, this burden is exacerbated further, as the evolutionary advantage of a large and complex human brain came at a great cost of women’s ... -
The multidimensional fatigue inventory (MFI-20): psychometrical testing in a Norwegian sample of inflammatory bowel disease (IBD) patients
(Journal article; Peer reviewed, 2022)OBJECTIVES To evaluate the psychometric properties of the Norwegian version of the multidimensional fatigue inventory (MFI-20) in patients with inflammatory bowel disease. METHODS Participants were recruited from nine ... -
Multidimensional tracking of phenotypes and organ involvement in a complete nationwide systemic sclerosis cohort
(Journal article; Peer reviewed, 2020)Objective SSc is a severe, heterogeneous multi-organ disease where population-based estimates on phenotypic spectrum, overall disease burden and societal impact are largely missing. Here the objective was to provide the ... -
Multidisciplinary approaches to identifying and managing global airways disease: Expert recommendations based on qualitative discussions
(Journal article; Peer reviewed, 2023)Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently co-exist and share pathologic features. Taking a “global” treatment approach benefits diagnosis and treatment of both, but care is often ... -
Multifasettert analyse av stabilitet og reologiske egenskaper i forbindelse med formulering av karbamidkremer
(Master thesis, 2023-06-06)Karbamidkrem har bred klinisk anvendelse innen dermatologi for behandling av tørr hud, kløe og atopisk eksem, takket være dens fuktighetsgivende og keratolytiske egenskaper. Kremformuleringer er imidlertid termodynamisk ... -
Multilocus analysis of SNP and metabolic data within a given pathway
(BMC Genomics 7(5), Peer reviewed; Journal article, 2006-01-13)Background: Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest challenges facing human geneticists ... -
Multimarker profiling identifies protective and harmful immune processes in heart failure: Findings from BIOSTAT-CHF
(Journal article; Peer reviewed, 2022)Aims The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to ... -
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
(Journal article; Peer reviewed, 2021)Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. To unlock ... -
Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma
(Peer reviewed; Journal article, 2015-08-07)Background: Orthotopic endometrial cancer models provide a unique tool for studies of tumour growth and metastatic spread. Novel preclinical imaging methods also have the potential to quantify functional tumour characteristics ... -
Multimodal imaging of thyroid cancer
(Journal article, 2020)Purpose of review Thyroid cancer is the most common endocrine cancer in adults with rising incidence. Challenges in imaging thyroid cancer are twofold: distinguishing thyroid cancer from benign thyroid nodules, which ... -
Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex
(Journal article; Peer reviewed, 2022)Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful tools to study brain development and dysfunction. However, whether organoids can functionally connect to a sensory network in vivo has ... -
Multimodality imaging in the immediate and long-term evaluation of bioresorbable vascular scaffolds : In patients with ST-elevation myocardial infarction
(Doctoral thesis, 2024-03-15)Introduksjon Akutt revaskularisering med primær perkutan koronar revaskularisering (PCI) er foretrukne strategi for pasienter med ST-elevasjons myokardielt infarkt (STEMI). Nåværende teknikk er å implantere stenter laget ... -
Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study
(Journal article; Peer reviewed, 2023)Background Multimorbidity (two or more comorbidities) is common among patients with acute heart failure, but comprehensive global information on its prevalence and clinical consequences across different world regions ... -
Multiomics tools for improved atherosclerotic cardiovascular disease management
(Journal article; Peer reviewed, 2023)Multiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) ... -
Multisteroid LC-MS/MS assay for glucocorticoids and androgens, and its application in Addison’s disease
(Peer reviewed; Journal article, 2013)Objective: Liquid chromatography–tandem mass spectrometry (LC–MS/MS) offers superior analytical specificity compared with immunoassays, but it is not available in many regions and hospitals due to expensive instrumentation ... -
The multitude of molecular analyses in cancer: the opening of Pandora’s box
(Peer reviewed; Journal article, 2014-09-03)The availability of large amounts of molecular data of unprecedented depth and width has instigated new paths of interdisciplinary activity in cancer research. Translation of such information to allow its optimal use in ... -
Muscle Strength and Male Sexual Function
(Journal article; Peer reviewed, 2024-01-12)Sexual dysfunction, in particular erectile dysfunction, is a common complaint among aging men. Obesity, diabetes, hypertension, and smoking are shown to be independent risk factors for erectile dysfunction, while ... -
Musculoskeletal Chronic Graft versus Host Disease-A Rare Complication to Allogeneic Hematopoietic Stem Cell Transplant: A Case-Based Report and Review of the Literature
(Journal article; Peer reviewed, 2022)Musculoskeletal graft versus host disease (GVHD) is a rare manifestation of chronic GVHD (cGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Left untreated, the disease can cause extensive ... -
Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma
(Journal article; Peer reviewed, 2023)Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ... -
Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers
(Journal article; Peer reviewed, 2022)Purpose: The identification of patients with homologous recombination deficiency (HRD) beyond BRCA1/2 mutations is an urgent task, as they may benefit from PARP inhibitors. We have previously developed a method to detect ...