Browsing Department of Clinical Science by Title
Now showing items 1867-1886 of 2397
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Proteasome‐mediated regulation of GATA2 expression and androgen receptor transcription in benign prostate epithelial cells
(Journal article; Peer reviewed, 2022)GATA2 has been shown to be an important transcription factor together with androgen receptor (AR) in prostate cancer cells. Less is known about GATA2 in benign prostate epithelial cells. We have investigated if GATA2 ... -
Protected sampling is preferable in bronchoscopic studies of the airway microbiome
(Journal article; Peer reviewed, 2017)The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with ... -
A protein extract from chicken reduces plasma homocysteine in rats
(Peer reviewed; Journal article, 2015-06-04)The present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar ... -
Protein Post-Translational Modification Crosstalk in Acute Myeloid Leukemia Calls for Action
(Peer reviewed; Journal article, 2019)Background: Post-translational modification (PTM) crosstalk is a young research field. However, there is now evidence of the extraordinary characterization of the different proteoforms and their interactions in a biological ... -
Protein profiling reveals inter-individual protein homogeneity of arachnoid cyst fluid and high qualitative similarity to cerebrospinal fluid
(Peer reviewed; Journal article, 2011-05-20)Background: The mechanisms behind formation and filling of intracranial arachnoid cysts (AC) are poorly understood. The aim of this study was to evaluate AC fluid by proteomics to gain further knowledge about ACs. Two goals ... -
Proteogenomic Analysis of Polymorphisms and Gene Annotation Divergences in Prokaryotes using a Clustered Mass Spectrometry-Friendly Database
(Peer reviewed; Journal article, 2011-01)Precise annotation of genes or open reading frames is still a difficult task that results in divergence even for data generated from the same genomic sequence. This has an impact in further proteomic studies, and also ... -
Proteogenomics in Microbiology: Taking the Right Turn at the Junction of Genomics and Proteomics
(Peer reviewed; Journal article, 2014-12)High-accuracy and high-throughput proteomic methods have completely changed the way we can identify and characterize proteins. MS-based proteomics can now provide a unique supplement to genomic data and add a new level of ... -
Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly ... -
Proteomic Analysis of Zebrafish Protein Recoding via mRNA Editing by ADAR Enzymes
(Journal article; Peer reviewed, 2022)RNA editing by adenosine deaminases of the ADAR family can lead to protein recoding, since inosine formed from adenosine in mRNA is complementary to cytosine; the resulting codon editing might introduce amino acid substitutions ... -
Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells
(Journal article; Peer reviewed, 2021)Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ... -
Proteomic Profiling of Primary Human Acute Myeloid Leukemia Cells Does Not Reflect Their Constitutive Release of Soluble Mediators
(Peer reviewed; Journal article, 2018-12-20)Acute myeloid leukemia (AML) is a heterogeneous disease, and communication between leukemic cells and their neighboring leukemia-supporting normal cells is involved in leukemogenesis. The bone marrow cytokine network is ... -
Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid
(Journal article; Peer reviewed, 2021)All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and ... -
A proteomics sample metadata representation for multiomics integration and big data analysis
(Journal article; Peer reviewed, 2021)The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding ... -
Psychiatric disorders, quality of life and effect of preoperative counselling in patients who undergo bariatric surgery
(Doctoral thesis, 2012-02-24)Background: Bariatric surgery is increasingly recommended as the treatment of choice for patients with severe obesity (BMI >40 kg/m2 or BMI >35 kg/m2 and a serious comorbid somatic condition). Surgical success, which ... -
The Psychological and HRQoL related Aftermaths of Extra Corporeal Membrane Oxygenation Treatment: A Cross‐Sectional Study
(Journal article; Peer reviewed, 2021)Objectives: To assess symptoms of post-traumatic stress disorder, anxiety, depression and health related quality of life in a sample of adult patients treated with veno-arterial extracorporeal membrane oxygenation. Design ... -
Psychological health in preschool children with underweight, overweight or obesity: a regional cohort study
(Journal article; Peer reviewed, 2021)Objective To examine if underweight (UW), overweight (OW) or obesity (OB), or body mass index (BMI) expressed as its SD score (BMI SDS), were associated with psychological difficulties in preschool children. Design ... -
Psychometric properties of the norwegian version of the electronic health literacy scale (eheals) among patients after percutaneous coronary intervention: Cross-sectional validation study
(Journal article; Peer reviewed, 2020)Background: Web-based technology has recently become an important source for sharing health information with patients after an acute cardiac event. Therefore, consideration of patients’ perceived electronic health (eHealth) ... -
Pubertal development in Norwegian boys : Ultrasound assessment of testicular volume, hormonal references, and association with anthropometric measurements
(Doctoral thesis, 2021-03-19)Background Puberty marks the transition from childhood to adulthood and is characterized by physiological and psychological changes leading to sexual maturity and reproductive function. Assessment of pubertal development ... -
Pubertal development in Norwegian girls
(Doctoral thesis, 2020-10-23)Background: Evidence suggests that girls worldwide are experiencing a decrease in age at pubertal onset, but data from Norwegian girls have not been available. Early pubertal timing is associated with adverse health ... -
Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study
(Peer reviewed; Journal article, 2016-11)Background: During the pandemic outbreak of the 2009 swine influenza (A(H1N1) pdm09), 32 fatal cases occurred in Norway and 19 of these were included in this study. Objectives: We characterised pulmonary changes in these ...