Blar i Department of Clinical Science på tittel

Viser treff 1907-1926 av 2576

    • Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells 

      Wergeland, Line; Sjøholt, Gry; Haaland, Ingvild; Hovland, Randi; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2007)
      Background: Acute myeloid leukemia (AML) cells are characterized by non-mutated TP53, high levels of Hdm2, and frequent mutation of the Flt3 receptor tyrosine kinase. The juxtamembrane mutation of FLT3 is the strongest ...

    • Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies 

      Yue, Yiyang; Creed, Jordan H.; Cote, David J.; Stampfer, Meir J.; Wang, Molin; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Furtado, Jeremy; Egan, Kathleen; Smith-Warner, Stephanie A. (Journal article; Peer reviewed, 2021)
      Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we ...

    • Pre-gestational diabetes: Maternal body mass index and gestational weight gain are associated with augmented umbilical venous flow, fetal liver perfusion, and thus birthweight 

      Lund, Agnethe; Ebbing, Cathrine; Rasmussen, Svein; Qvigstad, Elisabeth; Kiserud, Torvid; Kessler, Jørg (Journal article; Peer reviewed, 2021)
      Objectives To assess how maternal body mass index and gestational weight gain are related to on fetal venous liver flow and birthweight in pregnancies with pre-gestational diabetes mellitus. Methods In a longitudinal ...

    • Pre-pregnancy obesity among immigrant and non-immigrant women in Norway: Prevalence, trends, and subgroup variations 

      Nilsen, Roy Miodini; Strandberg, Ragnhild Bjarkøy; Yaya, Yaliso; Fismen, Anne-Siri; Macsali, Ferenc; Morken, Nils-Halvdan; Gomez Real, Francisco; Schytt, Erica; Skirnisdottir Vik, Eline; Sørbye, Linn Marie (Journal article; Peer reviewed, 2024)
      Introduction This study assessed prevalence and time trends of pre-pregnancy obesity in immigrant and non-immigrant women in Norway and explored the impact of immigrants' length of residence on pre-pregnancy obesity ...

    • Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis 

      Ahmad, Abrar; Lim, Lee-Ling; Morieri, Mario Luca; Tam, Claudia Ha-ting; Cheng, Feifei; Chikowore, Tinashe; Dudenhöffer-Pfeifer, Monika; Fitipaldi, Hugo; Huang, Chuiguo; Kanbour, Sarah; Sarkar, Sudipa; Koivula, Robert Wilhelm; Motala, Ayesha A.; Tye, Sok Cin; Yu, Gechang; Zhang, Yingchai; Provenzano, Michele; Sherifali, Diana; de Souza, Russell J.; Tobias, Deirdre Kay; Franks, Paul W.; Rich, Stephen S.; Wagner, Robert; Vilsbøll, Tina; Vesco, Kimberly K.; Udler, Miriam S.; Tuomi, Tiinamaija; Sweeting, Arianne; Sims, Emily K.; Sherr, Jennifer L.; Semple, Robert K.; Reynolds, Rebecca M.; Redondo, Maria J.; Redman, Leanne M.; Pratley, Richard E.; Pop-Busui, Rodica; Pollin, Toni I.; Perng, Wei; Pearson, Ewan R.; Ozanne, Susan E.; Owen, Katharine R.; Oram, Richard; Murphy, Rinki; Mohan, Viswanathan; Misra, Shivani; Meigs, James B.; Mathioudakis, Nestoras; Mathieu, Chantal; Ma, Ronald C. W.; Loos, Ruth J. F.; Lim, Siew S.; Laffel, Lori M.; Kwak, Soo Heon; Josefson, Jami L.; Hood, Korey K.; Hivert, Marie-France; Hirsch, Irl B.; Hattersley, Andrew T.; Griffin, Kurt; Greeley, Siri Atma W.; Gottlieb, Peter A.; Gloyn, Anna L.; Florez, Jose C.; Dennis, John M.; Costacou, Tina; Boyle, Kristen; Billings, Liana K.; Brown, Rebecca J.; Philipson, Louis H.; Nolan, John J.; Eckel, Robert H.; Mixter, Emily; Mekonnen, Eskedar Getie; Gruber, Chandra; Fawcett, Andrea J.; de Souza, Russell; Auh, Sungyoung; Zhu, Yeyi; Zhang, Cuilin; Saint-Martin, Cécile; Pomares-Millan, Hugo; Njølstad, Pål Rasmus; Nakabuye, Mariam; Molnes, Janne; McGovern, Andrew; Maloney, Kristin A.; Flanagan, Sarah E.; de Franco, Elisa; Aukrust, Ingvild; Polak, Michel; Beltrand, Jacques; Zhou, Shao J.; White, Sara L.; Hannah, Wesley; Wentworth, John M.; Vatier, Camille; Van der Schueren, Bart; Urazbayeva, Marzhan; Ukke, Gebresilasea Gendisha; Taylor, Rachael; Støy, Julie; Stefan, Norbert; Steck, Andrea K.; Steenackers, Nele; Stanislawski, Maggie A.; Speake, Cate; Sheu, Wayne Huey-Herng; Selvin, Elizabeth; Scholtens, Denise M.; Monaco, Gabriela S. F.; Santhakumar, Vanessa; Saeed, Zeb; Ried-Larsen, Mathias; Ray, Debashree; Jain, Rashmi; Quinteros, Alejandra; Powe, Camille E.; Petrie, John R.; Perez, Dianna; Pazmino, Sofia; Pathirana, Maleesa; Pankow, James S.; Onengut-Gumuscu, Suna; Morton, Robert W.; Lowe, William L.; Long, S. Alice; Liu, Kai; Libman, Ingrid M.; Leung, Gloria K. W.; Leong, Aaron; Koivula, Robert W.; Jones, Angus G.; Johnson, Randi K.; Hoag, Benjamin; Ismail, Heba M.; Harris-Kawano, Arianna; Hansen, Torben; Habibi, Nahal; Guasch-Ferré, Marta; Grieger, Jessica A.; Goodarzi, Mark O.; Gitelman, Stephen E.; Fitzpatrick, Stephanie L.; Fernández-Balsells, María Mercè; Evans-Molina, Carmella; DiMeglio, Linda A.; Dickens, Laura T.; Deutsch, Aaron J.; Dawed, Adem Y.; Dabelea, Dana; Clemmensen, Christoffer; Chivers, Sian C.; Chen, Mingling; Bonham, Maxine P.; Andersen, Mette K.; Amouyal, Chloé; Young, Katherine; Yamamoto, Jennifer M.; Wong, Jessie J.; Wang, Caroline C.; Wallace, Amelia S.; Tosur, Mustafa; Thuesen, Anne Cathrine B.; Takele, Wubet Worku; Svalastoga, Pernille; Sevilla-Gonzalez, Magdalena; Semnani-Azad, Zhila; Schön, Martin; Rooney, Mary R.; Raghavan, Sridharan; Prystupa, Katsiaryna; Pilla, Scott J.; Patel, Kashyap Amratlal; Ozkan, Bige; Naylor, Rochelle N.; Most, Jasper; Miller, Rachel G.; Mclennan, Niamh-Maire; Massey, Robert; Männistö, Jonna M. E.; Lim, Lee-Ling; Kreienkamp, Raymond J.; Kettunen, Jarno L. T.; Kahkoska, Anna R.; Jacobsen, Laura M.; Ikle, Jennifer M.; Hughes, Alice; Haider, Eram; Gaillard, Romy; Gingras, Véronique; Gillard, Pieter; Francis, Ellen C.; Felton, Jamie L.; Duan, Daisy; Cromer, Sara J.; Corcoy, Rosa; Colclough, Kevin; Clark, Amy L.; Bodhini, Dhanasekaran; Benham, Jamie L.; Aiken, Catherine; Merino, Jordi; Tobias, Deirdre K.; Gomez, Maria F.; Mathioudakis, Nestoras (Journal article; Peer reviewed, 2024)
      Background Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). Methods We conducted a systematic review and meta-analysis of ...

    • Preclinical activity of resazurin in acute myeloid leukaemia 

      Ha, Trung Quang; Andresen, Vibeke; Erikstein, Bjarte Skoe; Popa, Mihaela-Lucia; Gullaksen, Stein-Erik; Reikvam, Håkon; Mc Cormack, Emmet; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2025)
      Resazurin, a phenoxazine used in cell viability assays, acts in vitro as an anti-leukaemic compound through the production of cellular reactive oxygen species (ROS) resulting in mitochondrial dysfunction and cell death. ...

    • Preclinical cardiac disease in women and men with primary aldosteronism 

      Aune, Arleen; Kokorina, Marina Victorovna; Grytaas, Marianne Aa.; Midtbø, Helga Bergljot; Løvås, Kristian; Gerdts, Eva (Journal article; Peer reviewed, 2021)
      Purpose: We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods: Conventional and speckle tracking ...

    • Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma 

      Hanes, Robert; Munthe, Else; Grad, Iwona; Han, Jianhua; Karlsen, Ida Tveit; Mc Cormack, Emmet; Meza-Zepeda, Leonardo A.; Stratford, Eva Wessel; Myklebost, Ola (Peer reviewed; Journal article, 2019-02-21)
      Background: FGFR inhibition has been proposed as treatment for dedifferentiated liposarcoma (DDLPS) with amplified FRS2, but we previously only demonstrated transient cytostatic effects when treating FRS2-amplified DDLPS ...

    • Preclinical models and molecular biomarkers. Tools to improve treatment in endometrial carcinoma 

      Fonnes, Tina (Doctoral thesis, 2018-11-30)
      Background: Endometrial carcinoma is the fourth most common cancer in European women, and incidence is increasing. No major improvements in treatment or survival have been achieved over the last decades, and an individualized ...

    • Preclinical molecular imaging in oncology – From chemical synthesis to clinical translatable applications 

      García de Jalón Viñegra, Elvira (Doctoral thesis, 2021-06-25)
      Background: Molecular imaging (MI) is fundamental in clinical settings for diagnosis, treatment selection, intraoperative guidance and treatment efficacy evaluation. This field has progressed rapidly in recent years, driven ...

    • Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight 

      Hammer, Barbara; Kadalayil, Latha; Boateng, Eistine; Buschmann, Dominik; Rezwan, Faisal I.; Wolff, Martin; Reuter, Sebastian; Bartel, Sabine; Knudsen, Gerd Toril Mørkve; Svanes, Cecilie; Holloway, John W.; Krauss-Etschmann, Susanne (Journal article; Peer reviewed, 2021)
      Background Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested that preconceptional paternal smoking is associated with adolescent ...

    • Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation. 

      Lindås, Roald; Tvedt, Tor Henrik Anderson; Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2014-10-08)
      Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active ...

    • Predicted signal peptides, and the role of the N-terminal tail, at the monoamine G-protein coupled receptors 5-HT2c and α2c 

      Jahnsen, Jan Anker (Doctoral thesis, 2015-03-06)
      Background: G-protein coupled receptors (GPCRs) have seven transmembrane helices and are situated in the cell membrane, where they transduce signals from specific ligands to the interior of the cell. The first step in the ...

    • Predicting physical activity in a national cohort of children born extremely preterm 

      Engan, Mette; Engeseth, Merete Salveson; Fevang, Silje Katrine Elgen; Vollsæter, Maria; Eide, Geir Egil; Røksund, Ola Drange; Halvorsen, Thomas; Clemm, Hege Havstad (Journal article; Peer reviewed, 2020)
      Predicting physical activity in a national cohort of children born extremely preterm. Objectives: To compare physical activity among school-aged children born extremely preterm or with extremely low birthweight (EP/ELBW) ...

    • Predicting preeclampsia from a history of preterm birth 

      Rasmussen, Svein; Ebbing, Cathrine; Irgens, Lorentz M. (Peer reviewed; Journal article, 2017-07-24)
      Objective: To assess whether women with a history of preterm birth, independent on the presence of prelabour rupture of the membranes (PROM) and growth deviation of the newborn, are more likely to develop preeclampsia with ...

    • Prediction of adverse perinatal outcome of small-forgestational- age pregnancy using size centiles and conditional growth centiles 

      Karlsen, Henriette Odland; Johnsen, S. L.; Rasmussen, Svein; Kiserud, Torvid (Peer reviewed; Journal article, 2016-08)
      Objective: To test whether adding conditional growth centiles to size centiles of estimated fetal weight (EFW) improves prediction of adverse perinatal outcome in pregnancies with or at risk of having a small-for-gestational-age ...

    • Prediction of indirect interactions in proteins 

      Prusis, Peteris; Uhlén, Staffan; Petrovska, Ramona; Lapinsh, Maris; Wikberg, Jarl E. S. (Peer reviewed; Journal article, 2006-03-22)
      Background: Both direct and indirect interactions determine molecular recognition of ligands by proteins. Indirect interactions can be defined as effects on recognition controlled from distant sites in the proteins, e.g. ...

    • Prediction of type 1 diabetes at birth: Cord blood metabolites vs genetic risk score in the Norwegian mother, father, and child cohort 

      Tapia, German; Suvitaival, Tommi; Ahonen, Linda; Lund-Blix, Nicolai Andre; Njølstad, Pål Rasmus; Joner, Geir; Skrivarhaug, Torild; Legido-Quigley, Cristina; Størdal, Ketil; Stene, Lars Christian Mørch (Journal article; Peer reviewed, 2021)
      Background and aim: Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We ...

    • Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel 

      Chrisanthar, Ranjan; Knappskog, Stian; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Skjønsberg, Gudbrand; Aas, Turid; Schlichting, Ellen; Fjösne, Hans E.; Nysted, Arne; Lillehaug, Johan; Lønning, Per Eystein (Peer reviewed; Journal article, 2011-04-27)
      Background: TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may ...

    • Predictive and prognostic markers in localized colon cancer : with emphasis on the biomarkers maspin, mismatch repair deficiency, CDX2, tumor grade, PD-L1, and tumor-infiltrating lymphocytes. 

      Hestetun, Kjersti Elvestad (Doctoral thesis, 2022-06-23)
      Colon cancer is one of the most common cancers worldwide. Predicting disease outcomes is challenging. Around 15-20% of patients will experience disease relapse. At the same time, a substantial fraction of patients will ...