Browsing Department of Clinical Science by Title
Now showing items 1924-1943 of 2431
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Quantitative proteomics comparison of arachnoid cyst fluid and cerebrospinal fluid collected perioperatively from arachnoid cyst patients
(Peer reviewed; Journal article, 2013-04-29)Background: There is little knowledge concerning the content and the mechanisms of filling of arachnoid cysts. The aim of this study was to compare the protein content of arachnoid cysts and cerebrospinal fluid by quantitative ... -
Quantitative User Data From a Chatbot Developed for Women With Gestational Diabetes Mellitus: Observational Study
(Journal article; Peer reviewed, 2022)Background: The rising prevalence of gestational diabetes mellitus (GDM) calls for the use of innovative methods to inform and empower these pregnant women. An information chatbot, Dina, was developed for women with GDM ... -
Questions about complementary and alternative medicine to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive pilot study
(Peer reviewed; Journal article, 2014-02-14)Background: Provision of clinically relevant information about complementary and alternative medicine (CAM) to health care professionals is not well described. The aim of the study was to assess questions about CAM to the ... -
A question–answer pair (QAP) database integrated with websites to answer complex questions submitted to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive study
(Peer reviewed; Journal article, 2012-03-15)Objective To assess a question–answer pair (QAP) database integrated with websites developed for drug information centres to answer complex questions effectively. Design Descriptive study with comparison of two subsequent ... -
Quetiapine, Misuse and dependency: A case-series of questions to a Norwegian network of drug information centers
(Journal article; Peer reviewed, 2021)Purpose: The second-generation antipsychotic quetiapine has been associated with misuse and dependency. We aimed to review questions to the Norwegian network of drug information centers concerning this potential drug safety ... -
Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
(Peer reviewed; Journal article, 2019)Background: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a ... -
Radiation induced brain necrosis after proton therapy for head and neck cancer
(Doctoral thesis, 2022-12-09)Protonterapi gir reduksjon i normalvevsdoser sammenlignet med strålebehandling med fotoner, og det er antatt at dette vil resultere i en lavere forekomst av stråleinduserte seinskader. For å kompensere for en økt biologisk ... -
Radiofrequency ablation of atrial fibrillation. Clinical results and studies of mechanisms
(Doctoral thesis, 2011-09-30)Introduction: Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia. AF requires a trigger that initiates the arrhythmia, and the presence of a predisposing substrate that perpetuates it. ... -
A radiogenomics application for prognostic profiling of endometrial cancer
(Journal article; Peer reviewed, 2021)Prognostication is critical for accurate diagnosis and tailored treatment in endometrial cancer (EC). We employed radiogenomics to integrate preoperative magnetic resonance imaging (MRI, n = 487 patients) with histologic-, ... -
Raising and characterization of polyclonal antibodies against the arginine transporter AAP3 from Leishmania donovani
(Master thesis, 2016-06-06)Leishmania is an intracellular protozoa causing the tropical disease leishmaniasis. The disease is spread by female sandflies from the Phlebotomus and the Lutzomyia genera, and can cause diverse manifestations ranging from ... -
ramr: an R/Bioconductor package for detection of rare aberrantly methylated regions
(Journal article; Peer reviewed, 2022)Motivation: With recent advances in the field of epigenetics, the focus is widening from large and frequent disease- or phenotype-related methylation signatures to rare alterations transmitted mitotically or transgenerationally ... -
Randomized controlled trials and alternative study designs in surgical oncology
(Journal article; Peer reviewed, 2023)Surgery is central to the cure of most solid cancers and an integral part of modern multimodal cancer management for early and advanced stage cancers. Decisions made by surgeons and multidisciplinary team members are based ... -
Randomized implementation of a primary human papillomavirus testing-based cervical cancer screening protocol for women 34 to 69 years in Norway
(Journal article; Peer reviewed, 2022)Background: Cervical cancer screening programs are facing a programmatic shift where screening protocol based on human papillomavirus testing (HPV-Screening protocol) is replacing the liquid-based cytology (LBC-Screening ... -
A randomized trial to determine the impact of indacaterol/glycopyrronium on nighttime oxygenation and symptoms in patients with moderate-to-severe COPD: The DuoSleep study
(Peer reviewed; Journal article, 2019-01-09)Purpose: This study investigated the effect of dual bronchodilation with the long-acting β-receptor agonist/long-acting muscarinic antagonist combination, indacaterol/glycopyrronium (IND/GLY), on nighttime oxygenation, ... -
A randomized, double-blind, placebo-controlled clinical study to investigate the efficacy of herring roe oil for treatment of psoriasis
(Journal article; Peer reviewed, 2020-05-07)The effect of omega-3 polyunsaturated fatty acid supplements in patients with psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration ... -
A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern
(Journal article; Peer reviewed, 2022)Background: Evaluation of susceptibility to emerging SARS-CoV-2 variants of concern (VOC) requires rapid screening tests for neutralising antibodies which provide protection. Methods: Firstly, we developed a receptor-binding ... -
A rat modell to assess interventions to reduce cardiotoxicity of anthracyclines Does pre-treatment with morphine reduce the cardiotoxicity of doxorubicin?
(Master thesis, 2008-05-30)A rat model to assess interventions to reduce cardiotoxicity of anthracyclines is of interest. The model should be able to induce significant myocardial damage rapidly but at the same time allow for measurement of protective ... -
Rationale and design of the Birkebeiner Ageing Study – a prospective cohort study of older endurance athletes
(Journal article; Peer reviewed, 2023)Background While regular physical activity is associated with reduced mortality and morbidity in general populations, health outcomes and functional capacity related to upholding strenuous endurance exercise beyond the ... -
Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial
(Journal article, 2021)Background: Recent advances in the treatment algorithms of early breast cancer have markedly improved overall survival. However, anthracycline- and trastuzumab-associated cardiotoxicity may lead to dose-reduction or halt ...