Blar i Department of Clinical Science på dokumenttype "Doctoral thesis"
Viser treff 21-40 av 258
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Biomarkers for Diabetes Mellitus in advanced Peripheral Arterial Disease. Diagnostic performance and outcome prediction of HbA1c, fasting plasma glucose and the oral glucose tolerance test
(Doctoral thesis, 2019-05-14)Background: At present, the diagnosis of diabetes mellitus (DM) is based on the result from either of three tests; HbA1c, fasting plasma glucose (FPG) or 2-hour post glucose-load value following an oral glucose tolerance ... -
Biomarkers of one-carbon metabolism and B-vitamin status : Targeted metabolomics in rats and humans exploring the effects of PPARα-activation and dietary composition
(Doctoral thesis, 2019-10-04)BACKGROUND: One-carbon metabolism is an overarching term describing central metabolic pathways involved in the transfer of one-carbon units. These include the methionine-homocysteine and folate cycles, as well as the choline ... -
Bloodstream infections and antimicrobial resistance in Zanzibar, Tanzania, with special focus on typhoid fever and malaria
(Doctoral thesis, 2024-08-27)Bakgrunn: Globalt bidrar infeksjonssykdommer signifikant til sykdom og død, og lavinntektsland er uforholdsmessig rammet. Ved livstruende infeksjoner som blodbaneinfeksjoner kan rask behandling med adekvate legemidler redde ... -
Brain plasticity after cognitive intervention in patients with mild cognitive impairment (MCI) evaluated by multimodal MR imaging in a randomized, controlled trial.
(Doctoral thesis, 2022-12-16)Hjerneplasitisitet undersøkt hos individer med mild kognitiv svikt etter PC-administrert arbeidsminnetrening, evaluert med multimodal MRI teknikk, en randomisert kontroll studie. Formål: Hovedmålet med studien var å ... -
Bridging the evidence gap for implementing antibiotic stewardship in Norway: Interventions, process measures and patient outcomes related to antibiotic prescribing in hospitals
(Doctoral thesis, 2019-12-09)Background: Antimicrobial resistance is a major challenge for patient safety worldwide, as a growing number of infections become difficult to treat and the advances made in modern medicine are threatened. Overuse and misuse ... -
Bronchoscopy of lesions suspicious of malignancy: Predictors of a higher diagnostic yield, the optimal combination of sampling techniques, and evaluation of endobronchial ultrasound with a rotating miniprobe. A retrospective cohort study and a prospective open randomised real-life study among physicians with various levels of experience
(Doctoral thesis, 2011-11-04)Aims (1) To evaluate various predictors for a higher diagnostic yield in bronchoscopy (2) To evaluate different combinations of sampling techniques in bronchoscopy of endobronchial visible lesions and peripheral lesions ... -
Calprotectin (S100A8/A9) and S100A12 in inflammatory arthritis : clinical and epidemiological studies of rheumatoid and psoriatic arthritis
(Doctoral thesis, 2007-12-14)Rheumatoid- and psoriatic arthritis (RA and PsA) are the two most prevalent inflammatory joint diseases in Caucasian. Different biomarkers in peripheral blood may contribute in the diagnostic and prognostic process, as ... -
Cardiac Function and Early Risk Markers for Cardiovascular Disease in Children and Young Adults Surviving Severe Childhood Disease
(Doctoral thesis, 2023-11-03)Sammendrag på norsk Bakgrunn Prosessene som ligger bak utvikling av hjerte-kar sykdom starter tidlig i livet og er avhengig av antall risikofaktorer og debuttidspunkt av disse. Noen grupper er mer utsatt for hjerte-kar ... -
Cardiac organ damage in systemic hypertension: Impact of gender, etiology, and comorbidities
(Doctoral thesis, 2024-03-15)Bakgrunn: Ukontrollert systemisk hypertensjon fører til økt risiko for kardiovaskulær sykdom og død både ved essensiell og sekundær hypertensjon. Den økte risikoen skyldes i stor grad utvikling av strukturelle og funksjonelle ... -
Cardiac Resynchronization Therapy (CRT): Patient Selection and Guideline Adherence : An Analysis of CRT Practice in Europe Based on the European Society of Cardiology CRT Survey II with 11088 patients in 42 countries.
(Doctoral thesis, 2020-09-04)Background/Aims Cardiac Resynchronization Therapy (CRT) reduces morbidity and mortality in patients with heart failure and electrical dyssynchrony. Recommendations for which patients should receive a CRT device are outlined ... -
Cardiotoxicity of Doxorubicin. A Study of Methods and Protective Interventions in Rat Models
(Doctoral thesis, 2015-03-13)Introduction: The clinical use of anthracyclines, like doxorubicin, is a double-edged sword. On one side, anthracyclines play an undisputed key role in the treatment of many neoplastic diseases. On the other side; ... -
Cardiovascular risk markers in aortic valve stenosis : Insights in peak systolic left ventricular function, ejection dynamics and obesity
(Doctoral thesis, 2020-12-04)Background: Aortic valve stenosis (AS) is the most prevalent valvular heart disease requiring valvular intervention. With no pharmacological treatment available, optimal management requires detection of early left ventricular ... -
Characterisation of Leishmania amino acid permease 3 (AAP3) coding sequences and flanking regions as a target of detection and diagnosis of the leishmaniases
(Doctoral thesis, 2020-05-29)The protozoan parasites of Leishmania genus are the etiological agents of the leishmaniases, diseases whose clinical manifestations range from being asymptomatic, self-healing cutaneous lesions, via mutilating muco-cutaneous ... -
Characterization of adipose tissue and liver innate immune cells in obesity-related insulin resistance
(Doctoral thesis, 2020-12-04)Obesity is a highly prevalent disease associated with a number of chronic and noncommunicable diseases including type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). Obesity ... -
Characterization of arachnoid cysts using clinical chemistry, qualitative and quantitative proteomics
(Doctoral thesis, 2013-05-03)Arachnoid cyst are benign intracranial lesions with a reported prevalence up to 1.1 % in the population. The origin of such cysts and the mechanisms of filling and sustaining are poorly understood. The aim of the thesis ... -
Choline consumption in Norway : Dietary sources, association with one-carbon and lipid metabolism and cardiovascular disease risk
(Doctoral thesis, 2022-03-18)Background: Choline is an essential nutrient involved in a wide variety of physiological functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism, and phosphatidylcholine (PC) is ... -
Chronic obstructive pulmonary disease (COPD): exacerbations and costs.
(Doctoral thesis, 2021-10-27)Background: Chronic obstructive pulmonary disease (COPD) is a major contributor to morbidity and mortality worldwide. Being a preventable disease in most cases, the burden on both patients and society may be reduced ... -
Chronic obstructive pulmonary disease and risk of lung cancer
(Doctoral thesis, 2020-12-08)Abstract Background: Lung cancer is a main cause of death in patients suffering from COPD and smokers with COPD have an increased risk of lung cancer compared to healthy smokers. COPD comprises a broad range of features, ... -
Cleaning at work and at home as related to lung health : With a focus on asthma, COPD and lung function decline, vulnerability established early in life and potential impact for the next generation
(Doctoral thesis, 2023-01-20)Bakgrunn Renhold er en dagligdags oppgave for mange, men betyr også eksponering for renholdskjemikalier og desinfeksjonsmidler som kan være skadelige for luftveiene og forårsake lungesykdom. Astma er den vanligste ... -
Clinical and molecular effects of guanylate cyclase C-activation
(Doctoral thesis, 2019-06-06)We studied a large Norwegian family who had been affected by chronic diarrhoea and other symptoms from the digestive tract throughout several generations. Our genetic studies showed that family members with diarrhoea shared ...