Browsing Department of Clinical Science by Title
Now showing items 2032-2051 of 2574
-
Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications
(Journal article; Peer reviewed, 2024)Degenerative mitral valve disease is a common valvular disease with two arguably distinct phenotypes: fibroelastic deficiency and Barlow’s disease. These phenotypes significantly alter the microstructures of the leaflets, ... -
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
(Peer reviewed; Journal article, 2013-10-05)Background: Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation ... -
Quantitative PCR Measurement of miR-371a-3p and miR-372-p Is Influenced by Hemolysis
(Peer reviewed; Journal article, 2019-05-22)Cell-free microRNAs have been reported as biomarkers for several diseases. For testicular germ cell tumors (GCT), circulating microRNAs 371a-3p and 372-3p in serum and plasma have been proposed as biomarkers for diagnostic ... -
Quantitative proteomics comparison of arachnoid cyst fluid and cerebrospinal fluid collected perioperatively from arachnoid cyst patients
(Peer reviewed; Journal article, 2013-04-29)Background: There is little knowledge concerning the content and the mechanisms of filling of arachnoid cysts. The aim of this study was to compare the protein content of arachnoid cysts and cerebrospinal fluid by quantitative ... -
Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients
(Journal article; Peer reviewed, 2024)Background Tumor recurrence and metastatic progression remains the leading cause for breast cancer related mortalities. However, the proteomes of patient- matched primary breast cancer (BC) and metastatic lesions have ... -
Quantitative User Data From a Chatbot Developed for Women With Gestational Diabetes Mellitus: Observational Study
(Journal article; Peer reviewed, 2022)Background: The rising prevalence of gestational diabetes mellitus (GDM) calls for the use of innovative methods to inform and empower these pregnant women. An information chatbot, Dina, was developed for women with GDM ... -
Questions about complementary and alternative medicine to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive pilot study
(Peer reviewed; Journal article, 2014-02-14)Background: Provision of clinically relevant information about complementary and alternative medicine (CAM) to health care professionals is not well described. The aim of the study was to assess questions about CAM to the ... -
A question–answer pair (QAP) database integrated with websites to answer complex questions submitted to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive study
(Peer reviewed; Journal article, 2012-03-15)Objective To assess a question–answer pair (QAP) database integrated with websites developed for drug information centres to answer complex questions effectively. Design Descriptive study with comparison of two subsequent ... -
Quetiapine, Misuse and dependency: A case-series of questions to a Norwegian network of drug information centers
(Journal article; Peer reviewed, 2021)Purpose: The second-generation antipsychotic quetiapine has been associated with misuse and dependency. We aimed to review questions to the Norwegian network of drug information centers concerning this potential drug safety ... -
The Rac1-inhibitor EHop-016 attenuates AML cell migration and enhances the efficacy of daunorubicin in MOLM-13 transplanted zebrafish larvae
(Journal article; Peer reviewed, 2024)Ras-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase implicated in cell migration and homing of hematopoietic cells to the hematopoietic niche, and is commonly overexpressed in acute myeloid leukemia (AML). This ... -
Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
(Peer reviewed; Journal article, 2019)Background: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a ... -
Radiation induced brain necrosis after proton therapy for head and neck cancer
(Doctoral thesis, 2022-12-09)Protonterapi gir reduksjon i normalvevsdoser sammenlignet med strålebehandling med fotoner, og det er antatt at dette vil resultere i en lavere forekomst av stråleinduserte seinskader. For å kompensere for en økt biologisk ... -
Radiofrequency ablation of atrial fibrillation. Clinical results and studies of mechanisms
(Doctoral thesis, 2011-09-30)Introduction: Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia. AF requires a trigger that initiates the arrhythmia, and the presence of a predisposing substrate that perpetuates it. ... -
A radiogenomics application for prognostic profiling of endometrial cancer
(Journal article; Peer reviewed, 2021)Prognostication is critical for accurate diagnosis and tailored treatment in endometrial cancer (EC). We employed radiogenomics to integrate preoperative magnetic resonance imaging (MRI, n = 487 patients) with histologic-, ... -
Radiomic profiles improve prognostication and reveal targets for therapy in cervical cancer
(Journal article; Peer reviewed, 2024)Cervical cancer (CC) is a major global health problem with 570,000 new cases and 266,000 deaths annually. Prognosis is poor for advanced stage disease, and few effective treatments exist. Preoperative diagnostic imaging ... -
Raising and characterization of polyclonal antibodies against the arginine transporter AAP3 from Leishmania donovani
(Master thesis, 2016-06-06)Leishmania is an intracellular protozoa causing the tropical disease leishmaniasis. The disease is spread by female sandflies from the Phlebotomus and the Lutzomyia genera, and can cause diverse manifestations ranging from ... -
ramr: an R/Bioconductor package for detection of rare aberrantly methylated regions
(Journal article; Peer reviewed, 2022)Motivation: With recent advances in the field of epigenetics, the focus is widening from large and frequent disease- or phenotype-related methylation signatures to rare alterations transmitted mitotically or transgenerationally ... -
Randomized clinical trial to assess whether the duration of cotrimoxazole preventive therapy in HIV patients with CD4 counts >350 CD4 cells/μL by antiretroviral treatment influences the rate of carriage of multidrug-resistant bacteria. Study protocol
(Report, 2016-09-20)Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis jirovecii pneumonia (PJP) and other infections in HIV positive patients with low immunity. In industrial ... -
Randomized controlled trials and alternative study designs in surgical oncology
(Journal article; Peer reviewed, 2023)Surgery is central to the cure of most solid cancers and an integral part of modern multimodal cancer management for early and advanced stage cancers. Decisions made by surgeons and multidisciplinary team members are based ...